| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
163 genes differentially expressed following the AZD-8055_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.161979 |
| FN1 | fibronectin 1 | 0.152956 |
| RPS6 | ribosomal protein S6 | 0.115561 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0941779 |
| MEF2A | myocyte enhancer factor 2A | 0.0926107 |
| RNF213 | ring finger protein 213 | 0.0792361 |
| ACTG1 | actin gamma 1 | 0.0720564 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0691091 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0684503 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0673008 |
| JMJD1C | jumonji domain containing 1C | 0.0641618 |
| MYO10 | myosin X | 0.063019 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0629197 |
| ATXN1 | ataxin 1 | 0.0600316 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0584629 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0581878 |
| ASPH | aspartate beta-hydroxylase | 0.0578565 |
| SFTPA2 | surfactant protein A2 | 0.0563174 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0528765 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0513669 |
| GPC6 | glypican 6 | 0.0505421 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0496417 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0485555 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0456477 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0435094 |
| MMP1 | matrix metallopeptidase 1 | 0.0433067 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0414189 |
| RPS3 | ribosomal protein S3 | 0.0413155 |
| PTMA | prothymosin, alpha | 0.0409865 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0406075 |
| NF1 | neurofibromin 1 | 0.0405744 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0402293 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0399121 |
| SPAG9 | sperm associated antigen 9 | 0.0397745 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0387372 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0382562 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0380257 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0373909 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0363071 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0356792 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0345532 |
| CD44 | CD44 molecule (Indian blood group) | 0.0317739 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0292334 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.028489 |
| GDA | guanine deaminase | 0.0265798 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0263425 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.026144 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.025134 |
| MYOF | myoferlin | 0.0244687 |
| PRKCA | protein kinase C, alpha | 0.0240253 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0238783 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0216348 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0202031 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0197463 |
| VIM | vimentin | 0.0192929 |
| ANXA2 | annexin A2 | 0.0191259 |
| PGK1 | phosphoglycerate kinase 1 | 0.0176572 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0170386 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0166395 |
| BPTF | bromodomain PHD finger transcription factor | 0.0157395 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0150223 |
| B2M | beta-2-microglobulin | 0.0121755 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0120262 |
| RPL37A | ribosomal protein L37a | 0.0116848 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0105362 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0104286 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0101336 |
| PTK2 | protein tyrosine kinase 2 | 0.0100824 |
| S100A10 | S100 calcium binding protein A10 | 0.0100274 |
| CLTC | clathrin, heavy chain (Hc) | 0.00873738 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0086761 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.00733547 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.00697931 |
| RBM39 | RNA binding motif protein 39 | 0.00651029 |
| LDHA | lactate dehydrogenase A | 0.00465223 |
| FTL | ferritin, light polypeptide | 0.00457939 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.00339963 |
| RPL19 | ribosomal protein L19 | 0.00224856 |
| INHBA | inhibin, beta A | 0.00195509 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | -0.184483 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.127837 |
| MT2A | metallothionein 2A | -0.123998 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.122765 |
| EFNA5 | ephrin-A5 | -0.108932 |
| EXT1 | exostosin glycosyltransferase 1 | -0.101062 |
| TMSB10 | thymosin beta 10 | -0.0941023 |
| COL5A1 | collagen, type V, alpha 1 | -0.0914847 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0909128 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0842974 |
| CDH13 | cadherin 13 | -0.0821249 |
| STC1 | stanniocalcin 1 | -0.0789133 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.076105 |
| PDE10A | phosphodiesterase 10A | -0.0748885 |
| NAV2 | neuron navigator 2 | -0.0741672 |
| MCL1 | myeloid cell leukemia 1 | -0.0695992 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0684085 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0655925 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0636049 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0631125 |
| RUNX1 | runt-related transcription factor 1 | -0.0622233 |
| RPL23 | ribosomal protein L23 | -0.0615296 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0602044 |
| RPS25 | ribosomal protein S25 | -0.0595411 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0579053 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.056561 |
| DIAPH2 | diaphanous-related formin 2 | -0.0565107 |
| RPS12 | ribosomal protein S12 | -0.0529845 |
| RPLP2 | ribosomal protein, large, P2 | -0.0514568 |
| RPL34 | ribosomal protein L34 | -0.0514222 |
| HMGA2 | high mobility group AT-hook 2 | -0.0507181 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.048948 |
| GOLGA4 | golgin A4 | -0.0479455 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0438236 |
| NDRG1 | N-myc downstream regulated 1 | -0.0436147 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0390657 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0364118 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0359168 |
| LAMB3 | laminin, beta 3 | -0.0339162 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0331397 |
| RPLP1 | ribosomal protein, large, P1 | -0.0316818 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.031355 |
| VCL | vinculin | -0.0297176 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0289327 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0271851 |
| RPS8 | ribosomal protein S8 | -0.0264933 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0239474 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0234561 |
| VMP1 | vacuole membrane protein 1 | -0.0234493 |
| RPS19 | ribosomal protein S19 | -0.0222754 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0208085 |
| IGF2 | insulin-like growth factor 2 | -0.0204037 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0177624 |
| MYO1E | myosin IE | -0.0173728 |
| PARD3 | par-3 family cell polarity regulator | -0.0172268 |
| FNIP1 | folliculin interacting protein 1 | -0.0171897 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.01707 |
| COL5A2 | collagen, type V, alpha 2 | -0.0126848 |
| SMYD3 | SET and MYND domain containing 3 | -0.0120801 |
| ENO1 | enolase 1, (alpha) | -0.0120604 |
| DST | dystonin | -0.0118151 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0116203 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0102802 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00971977 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.00878429 |
| CANX | calnexin | -0.00835585 |
| SMAD3 | SMAD family member 3 | -0.00809315 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0076156 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00702033 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00675003 |
| PKM | pyruvate kinase, muscle | -0.0063228 |
| RPL12 | ribosomal protein L12 | -0.00620425 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.00596956 |
| COL1A1 | collagen, type I, alpha 1 | -0.00575794 |
| GLIS3 | GLIS family zinc finger 3 | -0.0048459 |
| TBC1D22A | TBC1 domain family, member 22A | -0.00444523 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00392444 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.00382952 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.00333858 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.00244798 |
| FLNB | filamin B, beta | -0.0019054 |
| RACK1 | receptor for activated C kinase 1 | -0.0015991 |
| JAK1 | Janus kinase 1 | -0.00159434 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.00116863 |
