AZD-8055_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.144889
FNDC3B fibronectin type III domain containing 3B 0.105385
PCLO piccolo presynaptic cytomatrix protein 0.0813776
SRP54 signal recognition particle 54kDa 0.0776946
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0737287
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0672141
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0662376
KMT2E lysine (K)-specific methyltransferase 2E 0.0650525
PARD3B par-3 family cell polarity regulator beta 0.0622802
KDM3A lysine (K)-specific demethylase 3A 0.0526727
SAMD4A sterile alpha motif domain containing 4A 0.0523368
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0510716
STAG2 stromal antigen 2 0.0504406
RPS2 ribosomal protein S2 0.0502825
ADGRL3 adhesion G protein-coupled receptor L3 0.0499975
GLS2 glutaminase 2 (liver, mitochondrial) 0.049334
ANKRD33B ankyrin repeat domain 33B 0.0455406
CCN2 cellular communication network factor 2 0.0454043
CDH19 cadherin 19, type 2 0.0453902
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0450665
MED13L mediator complex subunit 13-like 0.0440433
RAD51B RAD51 paralog B 0.0411474
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0406679
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.040337
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0395957
MYH9 myosin, heavy chain 9, non-muscle 0.0395863
ARB2A ARB2 cotranscriptional regulator A 0.0394746
WNK1 WNK lysine deficient protein kinase 1 0.0391561
ZFAND3 zinc finger, AN1-type domain 3 0.0384356
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0380893
TRA2A transformer 2 alpha homolog (Drosophila) 0.038054
PARD3 par-3 family cell polarity regulator 0.0369128
SKIC3 SKI3 subunit of superkiller complex 0.0368712
ANK2 ankyrin 2, neuronal 0.0366914
ADGRL2 adhesion G protein-coupled receptor L2 0.0361163
CDC14A cell division cycle 14A 0.0359162
PHF3 PHD finger protein 3 0.0357227
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0354498
RICTOR RPTOR independent companion of MTOR, complex 2 0.0353867
KMT2C lysine (K)-specific methyltransferase 2C 0.0350818
ZC3H12B zinc finger CCCH-type containing 12B 0.034859
EEF2 eukaryotic translation elongation factor 2 0.0347277
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0346989
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.034604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0344813
UBN2 ubinuclein 2 0.0338987
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0335475
TTC28 tetratricopeptide repeat domain 28 0.0329316
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0318588
CAMTA1 calmodulin binding transcription activator 1 0.0317335
TSC22D2 TSC22 domain family, member 2 0.0314716
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0314296
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0314246
HMCN1 hemicentin 1 0.0311767
PDIA3 protein disulfide isomerase family A, member 3 0.0310301
VMP1 vacuole membrane protein 1 0.0309266
RBM33 RNA binding motif protein 33 0.0305806
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0303197
FAM171B family with sequence similarity 171, member B 0.0303154
RYBP RING1 and YY1 binding protein 0.0301466
WSB1 WD repeat and SOCS box containing 1 0.0300571
CUX1 cut-like homeobox 1 0.0299854
SNX6 sorting nexin 6 0.0292466
SREBF2 sterol regulatory element binding transcription factor 2 0.0288757
SP3 Sp3 transcription factor 0.0284916
COG5 component of oligomeric golgi complex 5 0.0284044
CTBP2 C-terminal binding protein 2 0.0281577
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0278919
NCOA2 nuclear receptor coactivator 2 0.0278869
TLK1 tousled-like kinase 1 0.02778
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0264479
NCAM2 neural cell adhesion molecule 2 0.0261756
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0260342
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0258937
YAP1 Yes-associated protein 1 0.0258145
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.025795
FBXO11 F-box protein 11 0.0257792
MED12L mediator complex subunit 12-like 0.0257407
NRDC nardilysin convertase 0.0256793
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.025548
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0255367
SETD2 SET domain containing 2 0.0253775
NHSL1 NHS-like 1 0.0253347
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0252505
FOXO1 forkhead box O1 0.0252449
ISG15 ISG15 ubiquitin-like modifier 0.0251708
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0250979
MFSD14A major facilitator superfamily domain containing 14A 0.0246805
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0240733
NBAS neuroblastoma amplified sequence 0.023811
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0237684
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0236745
TNRC6A trinucleotide repeat containing 6A 0.0235563
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0231625
CANX calnexin 0.0230691
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0230373
RPL3 ribosomal protein L3 0.0230349
PDS5A PDS5 cohesin associated factor A 0.0230304
STK38 serine/threonine kinase 38 0.0229552
CCNG2 cyclin G2 0.0229534

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.139006
TMSB10 thymosin beta 10 -0.0965871
PCDH9 protocadherin 9 -0.0873097
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0834344
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0749002
GPC3 glypican 3 -0.0690837
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0660177
PHIP pleckstrin homology domain interacting protein -0.0637314
CDH10 cadherin 10, type 2 (T2-cadherin) -0.061873
MKI67 marker of proliferation Ki-67 -0.0570627
TPT1 tumor protein, translationally-controlled 1 -0.0563711
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0502573
GNAS GNAS complex locus -0.0497717
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0462639
MYL12B myosin, light chain 12B, regulatory -0.0455641
PGK1 phosphoglycerate kinase 1 -0.0444464
RPLP1 ribosomal protein, large, P1 -0.0439123
RAI1 retinoic acid induced 1 -0.04304
RPL35A ribosomal protein L35a -0.0425937
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0420659
CADM2 cell adhesion molecule 2 -0.0419738
ENO1 enolase 1, (alpha) -0.0416139
TUBA1B tubulin, alpha 1b -0.0410119
NCOR1 nuclear receptor corepressor 1 -0.0399876
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.038359
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0379074
H1-0 H1.0 linker histone -0.0370836
RAD21 RAD21 homolog (S. pombe) -0.0368722
VCL vinculin -0.0354258
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0352241
SFRP4 secreted frizzled-related protein 4 -0.0351872
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0351343
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0350588
RPL23 ribosomal protein L23 -0.0343689
CNRIP1 cannabinoid receptor interacting protein 1 -0.0340061
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333763
TXNRD1 thioredoxin reductase 1 -0.033318
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.032898
COL1A2 collagen, type I, alpha 2 -0.032373
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0321453
SGO2 shugoshin 2 -0.0319674
COL5A2 collagen, type V, alpha 2 -0.031774
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.03144
ARHGAP24 Rho GTPase activating protein 24 -0.031404
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0310607
KIF4A kinesin family member 4A -0.0310115
DEK DEK proto-oncogene -0.031007
HMGB1 high mobility group box 1 -0.0309204
RPL34 ribosomal protein L34 -0.0307509
FTL ferritin, light polypeptide -0.0307365
S100A9 S100 calcium binding protein A9 -0.0299152
RPL19 ribosomal protein L19 -0.0297155
ITGAV integrin, alpha V -0.0294883
ZFPM2 zinc finger protein, FOG family member 2 -0.0290362
MAML2 mastermind-like 2 (Drosophila) -0.0288686
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0288664
S100A10 S100 calcium binding protein A10 -0.028826
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0282702
FOXP2 forkhead box P2 -0.0282385
CENPF centromere protein F, 350/400kDa -0.0281952
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0279094
CCDC102B coiled-coil domain containing 102B -0.0278448
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0273579
BPTF bromodomain PHD finger transcription factor -0.0273527
RPS27A ribosomal protein S27a -0.0273512
YBX1 Y box binding protein 1 -0.0272529
RPS21 ribosomal protein S21 -0.0265939
ZNF207 zinc finger protein 207 -0.0265332
SYT1 synaptotagmin I -0.0265065
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0264883
VDAC1 voltage-dependent anion channel 1 -0.0264037
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0261232
ANKRD12 ankyrin repeat domain 12 -0.0260421
CBX3 chromobox homolog 3 -0.0259339
RPS4X ribosomal protein S4, X-linked -0.0258212
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0257873
PHACTR4 phosphatase and actin regulator 4 -0.0257417
DST dystonin -0.02561
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0254917
PEG10 paternally expressed 10 -0.0254391
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.025403
SPTSSA serine palmitoyltransferase, small subunit A -0.0252311
CXADR coxsackie virus and adenovirus receptor -0.0250463
PFN1 profilin 1 -0.0248934
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0245302
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0243078
TENM2 teneurin transmembrane protein 2 -0.023876
SAMD11 sterile alpha motif domain containing 11 -0.0238668
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0238241
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.023733
CALU calumenin -0.0235964
CCDC88A coiled-coil domain containing 88A -0.0234879
FBXO27 F-box protein 27 -0.0227899
TMEM123 transmembrane protein 123 -0.0226998
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0224743
RPLP0 ribosomal protein, large, P0 -0.0224327
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0222189
ROMO1 reactive oxygen species modulator 1 -0.0221131
SCAF11 SR-related CTD-associated factor 11 -0.0220448
PHF20 PHD finger protein 20 -0.0219139