| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.483762 |
| RPS16 | ribosomal protein S16 | 0.151789 |
| FNDC3B | fibronectin type III domain containing 3B | 0.15105 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.143172 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.135792 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.126435 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.120277 |
| NAV2 | neuron navigator 2 | 0.117414 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.115887 |
| MYOF | myoferlin | 0.103638 |
| AHNAK | AHNAK nucleoprotein | 0.103636 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0900478 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0833194 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0794459 |
| EGFR | epidermal growth factor receptor | 0.0793843 |
| SBF2 | SET binding factor 2 | 0.0792834 |
| FMNL2 | formin-like 2 | 0.0788805 |
| SMAD3 | SMAD family member 3 | 0.0777007 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0747374 |
| MT2A | metallothionein 2A | 0.0723441 |
| ACTG1 | actin gamma 1 | 0.0710034 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.066801 |
| DST | dystonin | 0.0658968 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0651977 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0612952 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0608881 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0584722 |
| SQSTM1 | sequestosome 1 | 0.0570714 |
| FNIP1 | folliculin interacting protein 1 | 0.0569982 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0535193 |
| SFTPA2 | surfactant protein A2 | 0.0530596 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0528264 |
| HMGA2 | high mobility group AT-hook 2 | 0.0526305 |
| GOLGB1 | golgin B1 | 0.0509905 |
| CDK19 | cyclin-dependent kinase 19 | 0.0505424 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0488763 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0474672 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0470538 |
| ANO6 | anoctamin 6 | 0.0469926 |
| RPS2 | ribosomal protein S2 | 0.0465052 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0456641 |
| PTK2 | protein tyrosine kinase 2 | 0.0449042 |
| CD44 | CD44 molecule (Indian blood group) | 0.0448551 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.0445479 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0443358 |
| APP | amyloid beta (A4) precursor protein | 0.0431448 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0429469 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0425763 |
| AFAP1 | actin filament associated protein 1 | 0.0425466 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0418529 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0414741 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0405555 |
| JMJD1C | jumonji domain containing 1C | 0.0404023 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0397075 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0395816 |
| OGA | O-GlcNAcase | 0.0394875 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0388718 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0381418 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0360371 |
| PHF3 | PHD finger protein 3 | 0.0354544 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0337904 |
| SERINC1 | serine incorporator 1 | 0.0334661 |
| STAG2 | stromal antigen 2 | 0.0334307 |
| PDE10A | phosphodiesterase 10A | 0.0326222 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0324136 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0322808 |
| KLHL24 | kelch-like family member 24 | 0.0320917 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0318525 |
| ATXN1 | ataxin 1 | 0.0314913 |
| RPS3 | ribosomal protein S3 | 0.0306709 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0302186 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0301623 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0298644 |
| ITGAV | integrin, alpha V | 0.029675 |
| MYO1E | myosin IE | 0.0289756 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0288696 |
| HDAC9 | histone deacetylase 9 | 0.0286814 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0284366 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0280806 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0280111 |
| USP34 | ubiquitin specific peptidase 34 | 0.0279728 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0277852 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0274779 |
| CA8 | carbonic anhydrase VIII | 0.0270928 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0270737 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0270401 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0269895 |
| LRRC49 | leucine rich repeat containing 49 | 0.0267896 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0264124 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0263102 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0261507 |
| CTBP2 | C-terminal binding protein 2 | 0.025986 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0258498 |
| EXOC4 | exocyst complex component 4 | 0.025806 |
| VIM | vimentin | 0.0257973 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0255258 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0251465 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.025083 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0249921 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0249851 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0930608 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0640611 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0587069 |
| PTMA | prothymosin, alpha | -0.0524335 |
| RTN4 | reticulon 4 | -0.0522087 |
| TMEM41B | transmembrane protein 41B | -0.0493215 |
| TMSB10 | thymosin beta 10 | -0.0482768 |
| ACTN4 | actinin, alpha 4 | -0.0476927 |
| TXNRD1 | thioredoxin reductase 1 | -0.0430021 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0413032 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0410634 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0392771 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | -0.037625 |
| RPL35A | ribosomal protein L35a | -0.0361532 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0337131 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0333438 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0321731 |
| EGR1 | early growth response 1 | -0.0315315 |
| PGK1 | phosphoglycerate kinase 1 | -0.0304553 |
| FTL | ferritin, light polypeptide | -0.0298905 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0297277 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0294874 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0292245 |
| FBL | fibrillarin | -0.0274921 |
| RPLP1 | ribosomal protein, large, P1 | -0.0268802 |
| FOSL1 | FOS-like antigen 1 | -0.0268452 |
| ANXA2 | annexin A2 | -0.0268213 |
| CALR | calreticulin | -0.0264701 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.0261987 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0260428 |
| KRT8 | keratin 8, type II | -0.0238565 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0236095 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0231036 |
| YBX1 | Y box binding protein 1 | -0.0227195 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0227045 |
| GNAS | GNAS complex locus | -0.0209361 |
| LDHA | lactate dehydrogenase A | -0.0208173 |
| CYCS | cytochrome c, somatic | -0.0207566 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0207111 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0200747 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.020034 |
| WDR45B | WD repeat domain 45B | -0.0195422 |
| TIMM50 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) | -0.0194932 |
| S100A10 | S100 calcium binding protein A10 | -0.0194886 |
| CALU | calumenin | -0.0193727 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0185068 |
| DSTN | destrin (actin depolymerizing factor) | -0.0184357 |
| ANLN | anillin, actin binding protein | -0.0183034 |
| RPLP2 | ribosomal protein, large, P2 | -0.0182548 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -0.0181635 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0181228 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.017473 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.017409 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0173474 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0172129 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0170817 |
| RRBP1 | ribosome binding protein 1 | -0.0170261 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0168874 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0166865 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0166793 |
| TUBA1B | tubulin, alpha 1b | -0.0166717 |
| PKM | pyruvate kinase, muscle | -0.0163979 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0162283 |
| HELLS | helicase, lymphoid-specific | -0.0158692 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0157286 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0157207 |
| RBM25 | RNA binding motif protein 25 | -0.0156695 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0155966 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0154661 |
| IER3 | immediate early response 3 | -0.0154459 |
| TPI1 | triosephosphate isomerase 1 | -0.0154016 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0153433 |
| TSC22D2 | TSC22 domain family, member 2 | -0.015244 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0152225 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0150336 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0150192 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0149656 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | -0.0148374 |
| RPS19 | ribosomal protein S19 | -0.0146224 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0145761 |
| TUBB | tubulin, beta class I | -0.0144235 |
| R3HDM1 | R3H domain containing 1 | -0.0141933 |
| RPS6 | ribosomal protein S6 | -0.0141256 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0140966 |
| MKI67 | marker of proliferation Ki-67 | -0.0138342 |
| FDPS | farnesyl diphosphate synthase | -0.013821 |
| PRDX1 | peroxiredoxin 1 | -0.0137346 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.013722 |
| RAN | RAN, member RAS oncogene family | -0.0136735 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0135566 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.013554 |
| HMGB1 | high mobility group box 1 | -0.013383 |
| CAVIN1 | caveolae associated protein 1 | -0.0132098 |
| HM13 | histocompatibility (minor) 13 | -0.0131943 |
| S100A9 | S100 calcium binding protein A9 | -0.013188 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0131423 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0131345 |
| INSIG1 | insulin induced gene 1 | -0.0129928 |
| LDLR | low density lipoprotein receptor | -0.012939 |
| IMMT | inner membrane protein, mitochondrial | -0.0127243 |
