| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-8055_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.179674 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.16726 |
| LMO7 | LIM domain 7 | 0.145784 |
| SQSTM1 | sequestosome 1 | 0.132241 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.119624 |
| GOLGB1 | golgin B1 | 0.100504 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0945635 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0880661 |
| SVIL | supervillin | 0.0875287 |
| INTS6 | integrator complex subunit 6 | 0.080198 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0793575 |
| EGFR | epidermal growth factor receptor | 0.0793095 |
| FMNL2 | formin-like 2 | 0.0770253 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0757454 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0750062 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0701379 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0669501 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0654605 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0653348 |
| TJP1 | tight junction protein 1 | 0.0626195 |
| SYT14 | synaptotagmin XIV | 0.0621889 |
| RPS8 | ribosomal protein S8 | 0.0620265 |
| SMAD3 | SMAD family member 3 | 0.0619849 |
| MYO5B | myosin VB | 0.0609468 |
| FAM107B | family with sequence similarity 107, member B | 0.0607234 |
| DSPP | dentin sialophosphoprotein | 0.0605929 |
| MYO6 | myosin VI | 0.0597074 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0586842 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0584216 |
| RACK1 | receptor for activated C kinase 1 | 0.0571685 |
| CLDN1 | claudin 1 | 0.0558021 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0541898 |
| LAMB3 | laminin, beta 3 | 0.0537663 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0526112 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0507352 |
| KLF6 | Kruppel-like factor 6 | 0.0490559 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0469242 |
| KRT17 | keratin 17, type I | 0.0468297 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0465911 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0457208 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0455074 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0454582 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0447253 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0447097 |
| HDAC9 | histone deacetylase 9 | 0.0442301 |
| RPL12 | ribosomal protein L12 | 0.0438672 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0431633 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0431477 |
| KYNU | kynureninase | 0.0427049 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0420679 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0407091 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0404629 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0398751 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0390954 |
| ITGB8 | integrin, beta 8 | 0.0387582 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0384893 |
| RPS6 | ribosomal protein S6 | 0.0381493 |
| RPS2 | ribosomal protein S2 | 0.0380945 |
| JAK1 | Janus kinase 1 | 0.038032 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0378231 |
| RPS3 | ribosomal protein S3 | 0.0376701 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0375407 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0373824 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0368511 |
| MYO1E | myosin IE | 0.0366669 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0366328 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0365393 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0364395 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0357196 |
| DSG2 | desmoglein 2 | 0.0357196 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0356742 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0348555 |
| HLA-E | major histocompatibility complex, class I, E | 0.0348274 |
| MACC1 | metastasis associated in colon cancer 1 | 0.034782 |
| RPS12 | ribosomal protein S12 | 0.0343344 |
| ABHD3 | abhydrolase domain containing 3 | 0.0332657 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0332301 |
| H2AC6 | H2A clustered histone 6 | 0.0328993 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0327568 |
| ZNF644 | zinc finger protein 644 | 0.03211 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0317359 |
| TLE4 | transducin-like enhancer of split 4 | 0.0312944 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0308334 |
| ATF3 | activating transcription factor 3 | 0.0307489 |
| NAV2 | neuron navigator 2 | 0.0307406 |
| RPL10A | ribosomal protein L10a | 0.0306748 |
| DST | dystonin | 0.0304678 |
| SNX9 | sorting nexin 9 | 0.0298246 |
| KLHL24 | kelch-like family member 24 | 0.0296548 |
| LAMC2 | laminin, gamma 2 | 0.0295932 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0295026 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0291217 |
| RPS25 | ribosomal protein S25 | 0.0287817 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0284911 |
| CNKSR3 | CNKSR family member 3 | 0.0283187 |
| RPL26 | ribosomal protein L26 | 0.0283117 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0282181 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.028176 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0279908 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.0277642 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.229105 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.162485 |
| LAMA4 | laminin, alpha 4 | -0.0965141 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0883024 |
| MKI67 | marker of proliferation Ki-67 | -0.0810524 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0783273 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0726041 |
| ANLN | anillin, actin binding protein | -0.0696066 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0686922 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0668229 |
| TGM2 | transglutaminase 2 | -0.0616858 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0612754 |
| TMSB10 | thymosin beta 10 | -0.0611966 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0609532 |
| PTMA | prothymosin, alpha | -0.0585363 |
| RTN4 | reticulon 4 | -0.0566358 |
| ASPH | aspartate beta-hydroxylase | -0.0550088 |
| PLAT | plasminogen activator, tissue | -0.0548849 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0531932 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0527664 |
| DIAPH3 | diaphanous-related formin 3 | -0.0514218 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0512474 |
| FOSL1 | FOS-like antigen 1 | -0.0484035 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0483182 |
| KRT19 | keratin 19, type I | -0.0456743 |
| PGK1 | phosphoglycerate kinase 1 | -0.0455772 |
| GOLGA4 | golgin A4 | -0.0435359 |
| RBM25 | RNA binding motif protein 25 | -0.0429809 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0426102 |
| FLNB | filamin B, beta | -0.0423817 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0416657 |
| S100A6 | S100 calcium binding protein A6 | -0.0414463 |
| ECT2 | epithelial cell transforming 2 | -0.0411387 |
| CALR | calreticulin | -0.0408259 |
| XPO1 | exportin 1 | -0.0397493 |
| TMEM123 | transmembrane protein 123 | -0.0391453 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0390529 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0388225 |
| TOP1 | topoisomerase (DNA) I | -0.0386189 |
| TXNRD1 | thioredoxin reductase 1 | -0.0371999 |
| NFIB | nuclear factor I/B | -0.0369169 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0368085 |
| ITGA6 | integrin, alpha 6 | -0.0367819 |
| CD2AP | CD2-associated protein | -0.0366027 |
| S100A10 | S100 calcium binding protein A10 | -0.036202 |
| EHF | ets homologous factor | -0.0360766 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0350955 |
| PKM | pyruvate kinase, muscle | -0.0350525 |
| CENPF | centromere protein F, 350/400kDa | -0.035004 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0348658 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0342907 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0340821 |
| ANXA2 | annexin A2 | -0.0334501 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0334206 |
| TFG | TRK-fused gene | -0.0332937 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0327695 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0325469 |
| ZNF148 | zinc finger protein 148 | -0.0324171 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0314814 |
| KRT8 | keratin 8, type II | -0.0314615 |
| ACTN4 | actinin, alpha 4 | -0.0312651 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0312154 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.031205 |
| MT2A | metallothionein 2A | -0.030313 |
| ATP13A3 | ATPase type 13A3 | -0.0302984 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | -0.0302687 |
| KRT18 | keratin 18, type I | -0.0300816 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0299037 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0296427 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0295384 |
| NDRG1 | N-myc downstream regulated 1 | -0.0294338 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0293165 |
| EZR | ezrin | -0.0290666 |
| WWC1 | WW and C2 domain containing 1 | -0.0289871 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0289611 |
| LDHA | lactate dehydrogenase A | -0.0287528 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -0.0275505 |
| EGR1 | early growth response 1 | -0.0274939 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0272241 |
| EREG | epiregulin | -0.0271821 |
| AFAP1 | actin filament associated protein 1 | -0.0271076 |
| DPYD | dihydropyrimidine dehydrogenase | -0.026915 |
| OSMR | oncostatin M receptor | -0.026834 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0267147 |
| RNF145 | ring finger protein 145 | -0.0265966 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0265919 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0264642 |
| LIMA1 | LIM domain and actin binding 1 | -0.0263664 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0260251 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0260224 |
| TNIK | TRAF2 and NCK interacting kinase | -0.025716 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0256566 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.024899 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.024827 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0247897 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0246981 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0244994 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0244915 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0239071 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0238493 |
