| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.171058 |
| ACTG1 | actin gamma 1 | 0.155985 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.136317 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.13304 |
| EXT1 | exostosin glycosyltransferase 1 | 0.128745 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.122939 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.12054 |
| JMJD1C | jumonji domain containing 1C | 0.115608 |
| SGMS2 | sphingomyelin synthase 2 | 0.112187 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.101377 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.100916 |
| HDAC9 | histone deacetylase 9 | 0.0972262 |
| RPL7 | ribosomal protein L7 | 0.0964845 |
| FRMD6 | FERM domain containing 6 | 0.0923403 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0910874 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0864816 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0811278 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0798842 |
| RPS2 | ribosomal protein S2 | 0.0718461 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0675715 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0655598 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0621634 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0591118 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0585651 |
| RUNX1 | runt-related transcription factor 1 | 0.0574144 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0568017 |
| MCL1 | myeloid cell leukemia 1 | 0.0566073 |
| RPL3 | ribosomal protein L3 | 0.0564226 |
| POTEF | POTE ankyrin domain family, member F | 0.0562453 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0562019 |
| CLTC | clathrin, heavy chain (Hc) | 0.0550345 |
| SET | SET nuclear proto-oncogene | 0.0532926 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0531368 |
| RCOR1 | REST corepressor 1 | 0.0530913 |
| RPL12 | ribosomal protein L12 | 0.0528389 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0524468 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0513378 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0503516 |
| SETX | senataxin | 0.0501692 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0489278 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0483918 |
| NAV3 | neuron navigator 3 | 0.0476936 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0472895 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0462814 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0458268 |
| STC1 | stanniocalcin 1 | 0.0456189 |
| CD68 | CD68 molecule | 0.0445671 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0429454 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0428918 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0428078 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.042763 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0425014 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0417502 |
| RPL8 | ribosomal protein L8 | 0.0412668 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0412374 |
| RPS18 | ribosomal protein S18 | 0.0401251 |
| USP34 | ubiquitin specific peptidase 34 | 0.0399195 |
| CD44 | CD44 molecule (Indian blood group) | 0.0394185 |
| TMF1 | TATA element modulatory factor 1 | 0.0390871 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0385072 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0384367 |
| RASA2 | RAS p21 protein activator 2 | 0.0378617 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0376202 |
| CORO1C | coronin, actin binding protein, 1C | 0.0375848 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0373527 |
| PAPOLA | poly(A) polymerase alpha | 0.036536 |
| BRD2 | bromodomain containing 2 | 0.0365106 |
| GOLGA4 | golgin A4 | 0.0364394 |
| GLRX | glutaredoxin (thioltransferase) | 0.0361416 |
| CALU | calumenin | 0.0358179 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.035596 |
| CAPRIN2 | caprin family member 2 | 0.0353906 |
| TRAM1 | translocation associated membrane protein 1 | 0.0350046 |
| RPS6 | ribosomal protein S6 | 0.0347096 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0342266 |
| UBC | ubiquitin C | 0.0340248 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0340003 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.033855 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0336357 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0334161 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0332445 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.032932 |
| ENO1 | enolase 1, (alpha) | 0.0325346 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0323387 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0318403 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0317831 |
| RPLP0 | ribosomal protein, large, P0 | 0.0315378 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0314533 |
| TUT7 | terminal uridylyl transferase 7 | 0.0311787 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0311761 |
| RACK1 | receptor for activated C kinase 1 | 0.0310626 |
| RPL7A | ribosomal protein L7a | 0.0306887 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0304404 |
| NUP58 | nucleoporin 58 | 0.0303957 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0293783 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0292219 |
| RPL32 | ribosomal protein L32 | 0.0288854 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0288524 |
| CANX | calnexin | 0.0285932 |
| FNIP1 | folliculin interacting protein 1 | 0.0284833 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | -0.0967092 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0953248 |
| MT2A | metallothionein 2A | -0.0855945 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0797918 |
| BNC2 | basonuclin 2 | -0.0787328 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0772375 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0766153 |
| TTR | transthyretin | -0.0726003 |
| CALD1 | caldesmon 1 | -0.067909 |
| MTAP | methylthioadenosine phosphorylase | -0.0650917 |
| RAD51B | RAD51 paralog B | -0.0646263 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0641612 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0582122 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0553517 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0521899 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0507754 |
| HMGA2 | high mobility group AT-hook 2 | -0.0485817 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0475507 |
| RAB3IP | RAB3A interacting protein | -0.0432841 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0418434 |
| ANK2 | ankyrin 2, neuronal | -0.0396907 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.038999 |
| RIGI | RNA sensor RIG-I | -0.0385909 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0372481 |
| FHIT | fragile histidine triad | -0.0370927 |
| NAV2 | neuron navigator 2 | -0.0370709 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0360322 |
| DIAPH3 | diaphanous-related formin 3 | -0.0353379 |
| SP100 | SP100 nuclear antigen | -0.0325509 |
| CCDC91 | coiled-coil domain containing 91 | -0.0318222 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0310867 |
| CUX1 | cut-like homeobox 1 | -0.0304819 |
| EXOC4 | exocyst complex component 4 | -0.0300196 |
| CDK6 | cyclin-dependent kinase 6 | -0.0296901 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0292834 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0286875 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0283596 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0282431 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0282079 |
| RPL35A | ribosomal protein L35a | -0.0281163 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0268566 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0267793 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0263588 |
| DIAPH2 | diaphanous-related formin 2 | -0.026251 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0259501 |
| NFIA | nuclear factor I/A | -0.0257269 |
| DENND1A | DENN/MADD domain containing 1A | -0.0256924 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.025518 |
| SMYD3 | SET and MYND domain containing 3 | -0.025404 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0252265 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0251573 |
| ASPH | aspartate beta-hydroxylase | -0.0250713 |
| WWOX | WW domain containing oxidoreductase | -0.0248377 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0243085 |
| TRIM56 | tripartite motif containing 56 | -0.0243019 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0240968 |
| CNTLN | centlein, centrosomal protein | -0.0239303 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0239002 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0233791 |
| SRPK2 | SRSF protein kinase 2 | -0.0233274 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0227632 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0225858 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0225847 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0223909 |
| MROH1 | maestro heat-like repeat family member 1 | -0.0223497 |
| RNF169 | ring finger protein 169 | -0.0223459 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0223426 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.022129 |
| FOXP1 | forkhead box P1 | -0.0217842 |
| MSI2 | musashi RNA-binding protein 2 | -0.0216927 |
| PLSCR1 | phospholipid scramblase 1 | -0.021623 |
| PKP4 | plakophilin 4 | -0.021557 |
| RNF220 | ring finger protein 220 | -0.0215526 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0213895 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0213627 |
| TCF12 | transcription factor 12 | -0.0213428 |
| RFX7 | regulatory factor X, 7 | -0.0213219 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0209554 |
| RPS24 | ribosomal protein S24 | -0.0206502 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0206478 |
| NF1 | neurofibromin 1 | -0.0202803 |
| CAST | calpastatin | -0.0195549 |
| RNF213 | ring finger protein 213 | -0.0195316 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0192368 |
| ADAMTSL1 | ADAMTS-like 1 | -0.0191798 |
| CEP250 | centrosomal protein 250kDa | -0.0190554 |
| PPA2 | pyrophosphatase (inorganic) 2 | -0.0189149 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.018815 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0187862 |
| ANXA2 | annexin A2 | -0.0183748 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0181887 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0179679 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0179087 |
| AOPEP | aminopeptidase O (putative) | -0.0178809 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0177269 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0177078 |
| GPHN | gephyrin | -0.0176433 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0175987 |
| AEBP2 | AE binding protein 2 | -0.0174683 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0174574 |
