AZD-8055_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPC6 glypican 6 0.106574
STC1 stanniocalcin 1 0.102664
RIMS2 regulating synaptic membrane exocytosis 2 0.0977869
NRG1 neuregulin 1 0.0944814
DOCK5 dedicator of cytokinesis 5 0.0939675
NALF1 NALCN channel auxiliary factor 1 0.0865661
RORA RAR-related orphan receptor A 0.0828427
KIF26B kinesin family member 26B 0.0817109
SCG2 secretogranin II 0.0770568
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.076051
COL22A1 collagen, type XXII, alpha 1 0.067781
ST18 suppression of tumorigenicity 18, zinc finger 0.0672941
NDRG1 N-myc downstream regulated 1 0.0666728
NCKAP5 NCK-associated protein 5 0.0641402
CPE carboxypeptidase E 0.0626437
SNTG1 syntrophin, gamma 1 0.061154
ZBTB20 zinc finger and BTB domain containing 20 0.0610102
NBEA neurobeachin 0.0592847
SNAP25 synaptosomal-associated protein, 25kDa 0.0586766
SVIL supervillin 0.05783
MCTP1 multiple C2 domains, transmembrane 1 0.0575185
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0570929
FNDC3A fibronectin type III domain containing 3A 0.0559939
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0552728
CHGB chromogranin B 0.0552032
MCL1 myeloid cell leukemia 1 0.0534646
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0534423
ACTG1 actin gamma 1 0.0519639
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0514119
FGF14 fibroblast growth factor 14 0.0510202
ASIC2 acid sensing (proton gated) ion channel 2 0.0507325
TSHZ2 teashirt zinc finger homeobox 2 0.0493592
CNKSR3 CNKSR family member 3 0.0488106
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0485038
INHBA inhibin, beta A 0.0429206
ERRFI1 ERBB receptor feedback inhibitor 1 0.0423282
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0420231
ZFHX3 zinc finger homeobox 3 0.0419105
ARFGEF3 ARFGEF family member 3 0.0416013
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0411051
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0398906
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0396458
SETX senataxin 0.0380213
BACE2 beta-site APP-cleaving enzyme 2 0.0375259
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0369314
LSAMP limbic system-associated membrane protein 0.0366487
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0352484
ANKRD17 ankyrin repeat domain 17 0.034547
RNF213 ring finger protein 213 0.034019
CDK13 cyclin-dependent kinase 13 0.0330704
LIMCH1 LIM and calponin homology domains 1 0.0323458
ASPH aspartate beta-hydroxylase 0.0319811
MAP1B microtubule-associated protein 1B 0.0317504
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0316878
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0315831
SMYD3 SET and MYND domain containing 3 0.0315555
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0315453
GMDS GDP-mannose 4,6-dehydratase 0.031367
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.0313483
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0313016
PAEP progestagen-associated endometrial protein 0.0312269
PHF14 PHD finger protein 14 0.031074
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.0309211
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0306898
SLC38A2 solute carrier family 38, member 2 0.0305114
EFNA5 ephrin-A5 0.0304258
MAP7 microtubule-associated protein 7 0.0304166
AGO2 argonaute RISC catalytic component 2 0.0300563
SCFD1 sec1 family domain containing 1 0.0297276
SIK3 SIK family kinase 3 0.0297081
RALYL RALY RNA binding protein-like 0.0293581
SIK2 salt-inducible kinase 2 0.029122
ZSWIM6 zinc finger, SWIM-type containing 6 0.0288067
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0287679
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0285834
SCFD2 sec1 family domain containing 2 0.0281073
EEF2 eukaryotic translation elongation factor 2 0.0280566
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.0280161
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0279425
GOLGB1 golgin B1 0.0279301
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0275352
IGFBP5 insulin-like growth factor binding protein 5 0.027066
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.027048
NANOS1 nanos homolog 1 (Drosophila) 0.0266263
ATF6 activating transcription factor 6 0.0263012
EPHA6 EPH receptor A6 0.02592
DENND4A DENN/MADD domain containing 4A 0.0257376
HM13 histocompatibility (minor) 13 0.0255836
PARM1 prostate androgen-regulated mucin-like protein 1 0.0254973
ANKH ANKH inorganic pyrophosphate transport regulator 0.0254738
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0254394
AGO3 argonaute RISC catalytic component 3 0.0250428
ZNF638 zinc finger protein 638 0.0247486
NAV2 neuron navigator 2 0.0246299
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0246013
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0245544
NF1 neurofibromin 1 0.0245481
SP100 SP100 nuclear antigen 0.0245339
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0244946
JMJD1C jumonji domain containing 1C 0.0244658

decreased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 -0.215446
PTMA prothymosin, alpha -0.147794
PDE10A phosphodiesterase 10A -0.134343
CENPF centromere protein F, 350/400kDa -0.105959
TOP2A topoisomerase (DNA) II alpha 170kDa -0.104588
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0554246
MIS18BP1 MIS18 binding protein 1 -0.0523052
SINHCAF SIN3-HDAC complex associated factor -0.0508221
ZNF292 zinc finger protein 292 -0.0489583
MKI67 marker of proliferation Ki-67 -0.0484135
CALCA calcitonin-related polypeptide alpha -0.0468401
PEG10 paternally expressed 10 -0.0454629
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0413907
ECT2 epithelial cell transforming 2 -0.0410087
VGF VGF nerve growth factor inducible -0.0408047
NUF2 NUF2, NDC80 kinetochore complex component -0.0402561
XPO1 exportin 1 -0.0401126
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0396353
NAMPT nicotinamide phosphoribosyltransferase -0.0377505
RAD21 RAD21 homolog (S. pombe) -0.0377294
MARCHF6 membrane associated ring-CH-type finger 6 -0.035723
CKAP5 cytoskeleton associated protein 5 -0.0354445
HMGB2 high mobility group box 2 -0.0352032
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0345215
PBK PDZ binding kinase -0.0339689
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0335488
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0332796
NFIA nuclear factor I/A -0.0326205
CAMTA1 calmodulin binding transcription activator 1 -0.0316977
GAS2L3 growth arrest-specific 2 like 3 -0.0314514
WSB1 WD repeat and SOCS box containing 1 -0.0311556
SASH1 SAM and SH3 domain containing 1 -0.0311357
TPX2 TPX2, microtubule-associated -0.0310306
SMC4 structural maintenance of chromosomes 4 -0.0309368
NCOR1 nuclear receptor corepressor 1 -0.0302261
PNISR PNN-interacting serine/arginine-rich protein -0.0294361
NAP1L1 nucleosome assembly protein 1-like 1 -0.0293657
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0292602
CA8 carbonic anhydrase VIII -0.0292406
RTN4 reticulon 4 -0.0291481
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0284585
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0283148
ANKRD28 ankyrin repeat domain 28 -0.0282265
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0277853
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0276597
PGAP1 post-GPI attachment to proteins 1 -0.0275749
MATR3 matrin 3 -0.0273365
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0269618
SLF1 SMC5-SMC6 complex localization factor 1 -0.0266287
ATAD2 ATPase family, AAA domain containing 2 -0.0260589
CDCA2 cell division cycle associated 2 -0.0259842
AURKA aurora kinase A -0.0258013
RLF rearranged L-myc fusion -0.0254757
ELL2 elongation factor, RNA polymerase II, 2 -0.0254298
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0251954
CDC27 cell division cycle 27 -0.0248428
NIPSNAP2 nipsnap homolog 2 -0.024731
KDM3A lysine (K)-specific demethylase 3A -0.0247225
PDE4B phosphodiesterase 4B, cAMP-specific -0.0242692
SGO2 shugoshin 2 -0.0240715
LCORL ligand dependent nuclear receptor corepressor-like -0.023915
TXNIP thioredoxin interacting protein -0.0238563
UVRAG UV radiation resistance associated -0.0238101
FCHSD2 FCH and double SH3 domains 2 -0.0234838
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0234572
PCM1 pericentriolar material 1 -0.02342
ANLN anillin, actin binding protein -0.0230093
JAM3 junctional adhesion molecule 3 -0.0230014
CEP152 centrosomal protein 152kDa -0.0230002
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0227631
KDM1A lysine (K)-specific demethylase 1A -0.0227597
PDE4D phosphodiesterase 4D, cAMP-specific -0.0226446
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0225889
NCAM1 neural cell adhesion molecule 1 -0.0224906
TTK TTK protein kinase -0.0224414
CDK8 cyclin-dependent kinase 8 -0.0224039
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.0223841
TUBB4B tubulin, beta 4B class IVb -0.0222992
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0221842
HLTF helicase-like transcription factor -0.0220172
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0219262
ZC3H15 zinc finger CCCH-type containing 15 -0.0217058
KCTD9 potassium channel tetramerization domain containing 9 -0.0214037
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0213165
KANTR KDM5C adjacent non-coding transcript -0.0213035
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0212816
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0211511
KIF14 kinesin family member 14 -0.0210899
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.021083
WDPCP WD repeat containing planar cell polarity effector -0.021021
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0209873
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0209346
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0208433
OGA O-GlcNAcase -0.0204106
BHLHE40 basic helix-loop-helix family, member e40 -0.020399
HELLS helicase, lymphoid-specific -0.0202986
NUSAP1 nucleolar and spindle associated protein 1 -0.020249
FNBP1L formin binding protein 1-like -0.0202409
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -0.0200771
IQGAP3 IQ motif containing GTPase activating protein 3 -0.0200607