AZD-8055_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG3 neuregulin 3 0.160948
FMN1 formin 1 0.15375
FNDC3B fibronectin type III domain containing 3B 0.150659
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0931258
NAV2 neuron navigator 2 0.0663537
SPAG9 sperm associated antigen 9 0.0608226
MSN moesin 0.0578187
CD44 CD44 molecule (Indian blood group) 0.0566435
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0561526
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0560273
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0507965
LAMP2 lysosomal-associated membrane protein 2 0.0488319
DST dystonin 0.0474814
NAMPT nicotinamide phosphoribosyltransferase 0.0471258
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0465316
SOD2 superoxide dismutase 2, mitochondrial 0.0458408
GOLGB1 golgin B1 0.0437715
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.04342
NOTCH2 notch 2 0.0423196
TRIO trio Rho guanine nucleotide exchange factor 0.0412945
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0412501
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0411878
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0401766
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0398459
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0394688
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0394514
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0392315
ICAM1 intercellular adhesion molecule 1 0.0376392
HSPA8 heat shock 70kDa protein 8 0.0371474
LINGO2 leucine rich repeat and Ig domain containing 2 0.0366292
AKAP12 A kinase (PRKA) anchor protein 12 0.0365546
AMOTL1 angiomotin like 1 0.0361325
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0353448
ATXN1 ataxin 1 0.0344968
NAV1 neuron navigator 1 0.0340675
ELL2 elongation factor, RNA polymerase II, 2 0.0337649
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0336528
CLIC4 chloride intracellular channel 4 0.0335277
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0334194
FMNL2 formin-like 2 0.0332059
AKAP13 A kinase (PRKA) anchor protein 13 0.0323893
CHD1 chromodomain helicase DNA binding protein 1 0.0322276
FRMD5 FERM domain containing 5 0.031625
SPTBN1 spectrin, beta, non-erythrocytic 1 0.031553
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0310786
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0310112
RASAL2 RAS protein activator like 2 0.0308352
ZMIZ1 zinc finger, MIZ-type containing 1 0.0305032
KMT2E lysine (K)-specific methyltransferase 2E 0.0295551
TENM3 teneurin transmembrane protein 3 0.0293298
ZFAND3 zinc finger, AN1-type domain 3 0.0291993
CFAP20DC CFAP20 domain containing 0.0289499
ALCAM activated leukocyte cell adhesion molecule 0.028732
FER fer (fps/fes related) tyrosine kinase 0.0285262
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0283201
EMP1 epithelial membrane protein 1 0.0282144
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0278944
EHBP1 EH domain binding protein 1 0.0277952
KYNU kynureninase 0.0274152
MYH9 myosin, heavy chain 9, non-muscle 0.0269521
ACTN1 actinin, alpha 1 0.0269494
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0268902
RUNX1 runt-related transcription factor 1 0.0268784
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0268749
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0268669
SMAD3 SMAD family member 3 0.0264958
MACF1 microtubule-actin crosslinking factor 1 0.026265
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.025455
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0254208
IL6ST interleukin 6 signal transducer 0.0250964
TMEM117 transmembrane protein 117 0.0249367
PTPRG protein tyrosine phosphatase, receptor type, G 0.0249284
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0246604
MED13L mediator complex subunit 13-like 0.0245756
ATP13A3 ATPase type 13A3 0.0244952
BACE2 beta-site APP-cleaving enzyme 2 0.0244075
CXCL8 chemokine (C-X-C motif) ligand 8 0.0240683
CEMIP2 cell migration inducing hyaluronidase 2 0.0240446
PTPRM protein tyrosine phosphatase, receptor type, M 0.0238279
DSCAM Down syndrome cell adhesion molecule 0.0238113
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0237056
CTTN cortactin 0.023662
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0236293
PTK2 protein tyrosine kinase 2 0.0236128
SEC24A SEC24 family member A 0.0235353
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0233719
SVIL supervillin 0.0233102
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.023248
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0230635
KDM7A lysine (K)-specific demethylase 7A 0.0227086
NPC1 Niemann-Pick disease, type C1 0.0226725
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0224806
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0221893
ARRDC3 arrestin domain containing 3 0.0219875
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0217984
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0217606
MMP12 matrix metallopeptidase 12 0.0217369
ANO6 anoctamin 6 0.0213135
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.021298
CYTH3 cytohesin 3 0.0211569

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.259667
FN1 fibronectin 1 -0.231002
NLGN1 neuroligin 1 -0.133714
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113369
PTMA prothymosin, alpha -0.0828488
FTL ferritin, light polypeptide -0.0675426
RPL35A ribosomal protein L35a -0.0645395
TMSB10 thymosin beta 10 -0.057661
RPLP1 ribosomal protein, large, P1 -0.0561894
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0545592
PMEL premelanosome protein -0.0513163
ACTG1 actin gamma 1 -0.0499224
IFI6 interferon, alpha-inducible protein 6 -0.0471299
VDAC1 voltage-dependent anion channel 1 -0.0464367
RPS6 ribosomal protein S6 -0.0442979
LSAMP limbic system-associated membrane protein -0.0426117
MT2A metallothionein 2A -0.0424129
RPS3 ribosomal protein S3 -0.041765
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.040096
RAD51B RAD51 paralog B -0.0385072
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0377716
KPNB1 karyopherin (importin) beta 1 -0.0374062
EIF1 eukaryotic translation initiation factor 1 -0.0372906
PGK1 phosphoglycerate kinase 1 -0.0349857
RPL37A ribosomal protein L37a -0.0349821
RPL34 ribosomal protein L34 -0.0329853
ENO1 enolase 1, (alpha) -0.0312758
RPS27A ribosomal protein S27a -0.0310376
RPS12 ribosomal protein S12 -0.0296903
S100A9 S100 calcium binding protein A9 -0.0290206
RPL23 ribosomal protein L23 -0.0287594
CADM1 cell adhesion molecule 1 -0.0284897
RPS14 ribosomal protein S14 -0.0279845
RPL36A ribosomal protein L36a -0.0279166
CTSD cathepsin D -0.0274436
FRMD4A FERM domain containing 4A -0.0272765
RPL31 ribosomal protein L31 -0.0266849
TPT1 tumor protein, translationally-controlled 1 -0.0265174
RPLP2 ribosomal protein, large, P2 -0.0262769
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0260049
RNF213 ring finger protein 213 -0.0257879
PRAME preferentially expressed antigen in melanoma -0.0248662
TNNC1 troponin C type 1 (slow) -0.0246237
TPI1 triosephosphate isomerase 1 -0.0245463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241586
RPS21 ribosomal protein S21 -0.0240574
RPL11 ribosomal protein L11 -0.024014
FHIT fragile histidine triad -0.023894
HLA-B major histocompatibility complex, class I, B -0.0238939
HLA-E major histocompatibility complex, class I, E -0.0236831
ZBTB20 zinc finger and BTB domain containing 20 -0.0233731
IFITM3 interferon induced transmembrane protein 3 -0.0228022
CALD1 caldesmon 1 -0.0226642
RPS8 ribosomal protein S8 -0.0225196
RIGI RNA sensor RIG-I -0.0224453
RPS29 ribosomal protein S29 -0.0222717
S100A10 S100 calcium binding protein A10 -0.0220252
RPS24 ribosomal protein S24 -0.0219437
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0216854
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0214838
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0213382
RPS19 ribosomal protein S19 -0.0212244
CBX3 chromobox homolog 3 -0.0208421
RPL36 ribosomal protein L36 -0.0206965
APOD apolipoprotein D -0.0203999
MACROD2 MACRO domain containing 2 -0.0200358
RPL38 ribosomal protein L38 -0.019836
RPS13 ribosomal protein S13 -0.0198189
GNAS GNAS complex locus -0.0198172
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -0.0194089
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0194022
B2M beta-2-microglobulin -0.0193908
RPL30 ribosomal protein L30 -0.0192661
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0191166
RPLP0 ribosomal protein, large, P0 -0.0190936
ENO2 enolase 2 (gamma, neuronal) -0.0190542
TUBB tubulin, beta class I -0.0188097
RPL37 ribosomal protein L37 -0.018756
RPS25 ribosomal protein S25 -0.0186961
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0185204
RPL12 ribosomal protein L12 -0.0182584
HSPB1 heat shock 27kDa protein 1 -0.0181869
RPS11 ribosomal protein S11 -0.0181089
PNISR PNN-interacting serine/arginine-rich protein -0.0179363
RPL8 ribosomal protein L8 -0.0179123
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0177654
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0176593
RPS16 ribosomal protein S16 -0.01759
RPL13A ribosomal protein L13a -0.0174802
S100A6 S100 calcium binding protein A6 -0.0172511
RPL26 ribosomal protein L26 -0.017193
RPL19 ribosomal protein L19 -0.0169291
RPS23 ribosomal protein S23 -0.0167209
RPL7A ribosomal protein L7a -0.0165956
RRBP1 ribosome binding protein 1 -0.0165791
RPL27A ribosomal protein L27a -0.0163735
MT1X metallothionein 1X -0.0163344
RPL9 ribosomal protein L9 -0.0162883
ZMYND8 zinc finger, MYND-type containing 8 -0.0161751
CALR calreticulin -0.0161652