| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PKM | pyruvate kinase, muscle | 0.133697 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.12779 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.117662 |
| BMP10 | bone morphogenetic protein 10 | 0.106906 |
| VCL | vinculin | 0.0899946 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0847484 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0802759 |
| AHNAK | AHNAK nucleoprotein | 0.071752 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0675701 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0656339 |
| EZR | ezrin | 0.061164 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0581229 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0577244 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0545697 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0488682 |
| FLNB | filamin B, beta | 0.0474077 |
| TMSB4X | thymosin beta 4, X-linked | 0.0449976 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.0448278 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0437045 |
| TJP1 | tight junction protein 1 | 0.042753 |
| GLI3 | GLI family zinc finger 3 | 0.0403134 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0401396 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0386807 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0376046 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0364466 |
| DUSP4 | dual specificity phosphatase 4 | 0.0360081 |
| MYO5C | myosin VC | 0.0337618 |
| FER1L6 | fer-1-like family member 6 | 0.0328526 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0311584 |
| ZNF608 | zinc finger protein 608 | 0.0301876 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0300646 |
| ENO1 | enolase 1, (alpha) | 0.0298502 |
| PLK2 | polo-like kinase 2 | 0.0297643 |
| PGK1 | phosphoglycerate kinase 1 | 0.0296633 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0291286 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0288003 |
| ZNF438 | zinc finger protein 438 | 0.0283547 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0277177 |
| EFNA5 | ephrin-A5 | 0.0260913 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0258889 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0254623 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0253462 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.0245559 |
| ITGA10 | integrin, alpha 10 | 0.0240051 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0238058 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0232664 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.023058 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0216927 |
| TXNRD1 | thioredoxin reductase 1 | 0.0215783 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0214403 |
| PYGB | phosphorylase, glycogen; brain | 0.0214345 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0213199 |
| BMP2K | BMP2 inducible kinase | 0.0209167 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0208772 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.0206937 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0206813 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0205592 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0201053 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0200972 |
| FOXP1 | forkhead box P1 | 0.02003 |
| UBQLN1 | ubiquilin 1 | 0.0198666 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0197316 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0195526 |
| TOB1 | transducer of ERBB2, 1 | 0.0194242 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0191538 |
| RNF145 | ring finger protein 145 | 0.0188196 |
| LOXL3 | lysyl oxidase-like 3 | 0.0187235 |
| ITGA6 | integrin, alpha 6 | 0.0186903 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0185754 |
| CCND1 | cyclin D1 | 0.0184606 |
| RPS18 | ribosomal protein S18 | 0.0180753 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0180541 |
| SETD5 | SET domain containing 5 | 0.0179037 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0178406 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | 0.0176884 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0176082 |
| LIMD1 | LIM domains containing 1 | 0.017494 |
| AFF4 | AF4/FMR2 family, member 4 | 0.017032 |
| RB1 | retinoblastoma 1 | 0.0167431 |
| ZNF217 | zinc finger protein 217 | 0.0165232 |
| USP47 | ubiquitin specific peptidase 47 | 0.0161684 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0160207 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0159218 |
| CLTC | clathrin, heavy chain (Hc) | 0.0159177 |
| UNC13A | unc-13 homolog A (C. elegans) | 0.0158577 |
| CRY1 | cryptochrome circadian clock 1 | 0.0157861 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0157288 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0154473 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0154127 |
| AKAP11 | A kinase (PRKA) anchor protein 11 | 0.0153545 |
| TRIM24 | tripartite motif containing 24 | 0.0151819 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0150941 |
| ONECUT2 | one cut homeobox 2 | 0.0150454 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 0.0149853 |
| BRD2 | bromodomain containing 2 | 0.0149417 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 0.0147538 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0146848 |
| ABHD12 | abhydrolase domain containing 12 | 0.0146324 |
| DUSP6 | dual specificity phosphatase 6 | 0.0145909 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0145494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.131262 |
| RPS6 | ribosomal protein S6 | -0.123145 |
| PTMA | prothymosin, alpha | -0.100967 |
| RPS8 | ribosomal protein S8 | -0.0961937 |
| ACTG1 | actin gamma 1 | -0.0771414 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0762818 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0716105 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0715425 |
| RPL37A | ribosomal protein L37a | -0.0715306 |
| RPL35A | ribosomal protein L35a | -0.0690578 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0661142 |
| DIAPH3 | diaphanous-related formin 3 | -0.0656137 |
| RPS19 | ribosomal protein S19 | -0.0646558 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0592961 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.058457 |
| RPLP2 | ribosomal protein, large, P2 | -0.0581648 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0539378 |
| RPL36 | ribosomal protein L36 | -0.0507138 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0503797 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0500566 |
| RPL31 | ribosomal protein L31 | -0.0493171 |
| RPL23 | ribosomal protein L23 | -0.0490475 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0489331 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0480971 |
| RPL13A | ribosomal protein L13a | -0.0462698 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0447747 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0439439 |
| NAV2 | neuron navigator 2 | -0.042817 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0426028 |
| B2M | beta-2-microglobulin | -0.0424903 |
| RPS27A | ribosomal protein S27a | -0.0422448 |
| RPS13 | ribosomal protein S13 | -0.0420695 |
| RPLP1 | ribosomal protein, large, P1 | -0.0416476 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0411941 |
| RPS3 | ribosomal protein S3 | -0.0411072 |
| RPS23 | ribosomal protein S23 | -0.040899 |
| VIM | vimentin | -0.0403634 |
| MKI67 | marker of proliferation Ki-67 | -0.0402384 |
| RPL9 | ribosomal protein L9 | -0.0382871 |
| RPL7A | ribosomal protein L7a | -0.0376579 |
| RPS25 | ribosomal protein S25 | -0.0368397 |
| RPL11 | ribosomal protein L11 | -0.0364572 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0364264 |
| FNIP1 | folliculin interacting protein 1 | -0.0360828 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0352106 |
| CENPF | centromere protein F, 350/400kDa | -0.034657 |
| RPL34 | ribosomal protein L34 | -0.0345772 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0343734 |
| MT2A | metallothionein 2A | -0.0336995 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0335054 |
| RPL37 | ribosomal protein L37 | -0.0329727 |
| NF1 | neurofibromin 1 | -0.032941 |
| RPLP0 | ribosomal protein, large, P0 | -0.0322004 |
| TMSB10 | thymosin beta 10 | -0.0315536 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0311616 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0311182 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0303681 |
| FTL | ferritin, light polypeptide | -0.0300832 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0298873 |
| MAP4 | microtubule-associated protein 4 | -0.0297359 |
| RPS12 | ribosomal protein S12 | -0.0295941 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0295388 |
| RPS5 | ribosomal protein S5 | -0.0294453 |
| RPL26 | ribosomal protein L26 | -0.0289096 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0284863 |
| TPM4 | tropomyosin 4 | -0.0282941 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0280763 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0280724 |
| RPS27 | ribosomal protein S27 | -0.027998 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0279023 |
| RPS21 | ribosomal protein S21 | -0.0276918 |
| NMD3 | NMD3 ribosome export adaptor | -0.0276686 |
| RPL19 | ribosomal protein L19 | -0.0275155 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0271941 |
| RPS24 | ribosomal protein S24 | -0.0266697 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0264829 |
| RAD51B | RAD51 paralog B | -0.0261001 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.026078 |
| ANXA2 | annexin A2 | -0.0259242 |
| DIAPH2 | diaphanous-related formin 2 | -0.0258515 |
| EHBP1 | EH domain binding protein 1 | -0.0258395 |
| GPHN | gephyrin | -0.0258393 |
| RPL28 | ribosomal protein L28 | -0.025729 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.025667 |
| RPS29 | ribosomal protein S29 | -0.0256146 |
| S100A6 | S100 calcium binding protein A6 | -0.0255796 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0254911 |
| ATF4 | activating transcription factor 4 | -0.0252886 |
| RPS15 | ribosomal protein S15 | -0.0248764 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0248653 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0248321 |
| PLCE1 | phospholipase C, epsilon 1 | -0.0247255 |
| CEP112 | centrosomal protein 112kDa | -0.0243683 |
| RPL30 | ribosomal protein L30 | -0.0242989 |
| RASAL2 | RAS protein activator like 2 | -0.0240761 |
| RPS11 | ribosomal protein S11 | -0.0237202 |
| EXOC4 | exocyst complex component 4 | -0.0235425 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0231366 |
| RPL8 | ribosomal protein L8 | -0.0228882 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.0226268 |
