AZD-8055_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.302302
HDAC9 histone deacetylase 9 0.125891
FNDC3B fibronectin type III domain containing 3B 0.111006
NAV2 neuron navigator 2 0.108929
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.102273
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0929721
TRIO trio Rho guanine nucleotide exchange factor 0.0830557
VCAN versican 0.0819509
VEGFA vascular endothelial growth factor A 0.0744917
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0744178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0740002
JMJD1C jumonji domain containing 1C 0.0710679
MYH9 myosin, heavy chain 9, non-muscle 0.0707092
RND3 Rho family GTPase 3 0.0698465
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0662515
FNIP1 folliculin interacting protein 1 0.0655779
MYOF myoferlin 0.0633303
SPAG9 sperm associated antigen 9 0.061319
GPC6 glypican 6 0.0611023
GOLGB1 golgin B1 0.0579909
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0576213
RAB7A RAB7A, member RAS oncogene family 0.0570808
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0567907
CADM1 cell adhesion molecule 1 0.0566205
NDRG1 N-myc downstream regulated 1 0.0564464
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0545888
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0542827
EEF2 eukaryotic translation elongation factor 2 0.0512914
SMAD3 SMAD family member 3 0.0506496
CD44 CD44 molecule (Indian blood group) 0.0497613
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0487624
SFTPA2 surfactant protein A2 0.0482422
AHR aryl hydrocarbon receptor 0.0481068
ZSWIM6 zinc finger, SWIM-type containing 6 0.0468208
PDE10A phosphodiesterase 10A 0.0468203
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0467523
ARRDC3 arrestin domain containing 3 0.0453593
ZNF292 zinc finger protein 292 0.0443183
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.042895
ANXA1 annexin A1 0.0413828
ANKRD28 ankyrin repeat domain 28 0.0406497
GOLGA4 golgin A4 0.0401938
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.040098
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0396746
CLTC clathrin, heavy chain (Hc) 0.0392888
GPR176 G protein-coupled receptor 176 0.038521
RB1CC1 RB1-inducible coiled-coil 1 0.0383522
SNX9 sorting nexin 9 0.0375018
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0363471
ZBTB38 zinc finger and BTB domain containing 38 0.0361954
FMNL2 formin-like 2 0.0353713
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0353047
OPTN optineurin 0.0352881
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0352401
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.03476
ADM adrenomedullin 0.0343274
DUSP10 dual specificity phosphatase 10 0.0338025
MBNL1 muscleblind-like splicing regulator 1 0.0336598
MORF4L2 mortality factor 4 like 2 0.033052
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0325077
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0320155
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0317418
TNS3 tensin 3 0.0311445
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0311401
APP amyloid beta (A4) precursor protein 0.0305938
CREBRF CREB3 regulatory factor 0.0304075
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0302785
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.030091
ZFAND3 zinc finger, AN1-type domain 3 0.0298804
FTH1 ferritin, heavy polypeptide 1 0.0294639
USP9X ubiquitin specific peptidase 9, X-linked 0.0291359
BACE2 beta-site APP-cleaving enzyme 2 0.0287437
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0286559
AKAP13 A kinase (PRKA) anchor protein 13 0.0285282
LAMP2 lysosomal-associated membrane protein 2 0.0282138
FAM107B family with sequence similarity 107, member B 0.0281959
CSPP1 centrosome and spindle pole associated protein 1 0.0280754
APLP2 amyloid beta (A4) precursor-like protein 2 0.0280161
MSN moesin 0.027847
HSPA8 heat shock 70kDa protein 8 0.027728
ATXN1 ataxin 1 0.0276898
TMEM132D transmembrane protein 132D 0.0276734
KYNU kynureninase 0.0274072
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0273423
PPARD peroxisome proliferator-activated receptor delta 0.0269469
SQSTM1 sequestosome 1 0.0269102
KIAA1217 KIAA1217 0.0268284
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0268157
RPS2 ribosomal protein S2 0.0263008
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0262597
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0258555
ZMIZ1 zinc finger, MIZ-type containing 1 0.0257163
BIRC3 baculoviral IAP repeat containing 3 0.0256597
ANO6 anoctamin 6 0.025587
MBNL2 muscleblind-like splicing regulator 2 0.0254356
RUNX1 runt-related transcription factor 1 0.0253988
DSCAM Down syndrome cell adhesion molecule 0.0253553
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.025185
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0250248
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.02501

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.184215
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12314
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0894108
TMSB10 thymosin beta 10 -0.0804561
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0803961
TPT1 tumor protein, translationally-controlled 1 -0.0796132
HLA-B major histocompatibility complex, class I, B -0.0794762
FTL ferritin, light polypeptide -0.0794325
FRMD4A FERM domain containing 4A -0.0714814
VCL vinculin -0.0614038
FN1 fibronectin 1 -0.0594188
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0587029
PTMA prothymosin, alpha -0.0574808
MT2A metallothionein 2A -0.0559283
IER3 immediate early response 3 -0.0552808
RPL35A ribosomal protein L35a -0.0525034
ACTG1 actin gamma 1 -0.0400109
PGK1 phosphoglycerate kinase 1 -0.0395057
HLA-A major histocompatibility complex, class I, A -0.0394761
COL1A1 collagen, type I, alpha 1 -0.0381223
WSB1 WD repeat and SOCS box containing 1 -0.0380684
TPM4 tropomyosin 4 -0.0368932
HMGA2 high mobility group AT-hook 2 -0.0354216
GNAS GNAS complex locus -0.0345709
RPL37A ribosomal protein L37a -0.0339635
IGFBP3 insulin-like growth factor binding protein 3 -0.0327364
RPS6 ribosomal protein S6 -0.0322303
RPL23 ribosomal protein L23 -0.0315936
IFI6 interferon, alpha-inducible protein 6 -0.0292215
RPLP1 ribosomal protein, large, P1 -0.0289459
RPS24 ribosomal protein S24 -0.0282958
RPS8 ribosomal protein S8 -0.0282125
CAVIN1 caveolae associated protein 1 -0.0281282
RPS12 ribosomal protein S12 -0.027638
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0272001
COL1A2 collagen, type I, alpha 2 -0.026211
RPS3 ribosomal protein S3 -0.0260665
IFITM3 interferon induced transmembrane protein 3 -0.0256253
RPS25 ribosomal protein S25 -0.0254957
RPLP2 ribosomal protein, large, P2 -0.0245228
RPL36A ribosomal protein L36a -0.024372
RPL34 ribosomal protein L34 -0.0243497
CTSD cathepsin D -0.0237409
PSD3 pleckstrin and Sec7 domain containing 3 -0.0237304
RPL31 ribosomal protein L31 -0.0235607
TIMP2 TIMP metallopeptidase inhibitor 2 -0.023452
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0231284
GLIS3 GLIS family zinc finger 3 -0.0228714
RPS19 ribosomal protein S19 -0.0223921
CALR calreticulin -0.0221524
RPL7A ribosomal protein L7a -0.0221351
RPS29 ribosomal protein S29 -0.0219591
ZMYND8 zinc finger, MYND-type containing 8 -0.02158
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.021475
NRN1 neuritin 1 -0.0208515
RPL19 ribosomal protein L19 -0.0207343
SFRP1 secreted frizzled-related protein 1 -0.0202657
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0202097
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0198511
RPL9 ribosomal protein L9 -0.0196587
RNF213 ring finger protein 213 -0.0190915
TPM1 tropomyosin 1 (alpha) -0.0189992
FLOT1 flotillin 1 -0.0188827
RTN4 reticulon 4 -0.0188112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0185835
RPS16 ribosomal protein S16 -0.018574
FAM20C family with sequence similarity 20, member C -0.0185706
COL5A1 collagen, type V, alpha 1 -0.0181519
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0179301
THBS2 thrombospondin 2 -0.0177756
S100A9 S100 calcium binding protein A9 -0.0177294
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0174502
SMYD3 SET and MYND domain containing 3 -0.017323
STC2 stanniocalcin 2 -0.0172841
KPNB1 karyopherin (importin) beta 1 -0.0170008
EGR1 early growth response 1 -0.0169338
RPS27A ribosomal protein S27a -0.0168242
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0167786
TGFBI transforming growth factor, beta-induced, 68kDa -0.0165546
VDAC1 voltage-dependent anion channel 1 -0.0164659
RPL36 ribosomal protein L36 -0.0164341
RPS13 ribosomal protein S13 -0.0163583
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0156422
RPS15 ribosomal protein S15 -0.0153744
RPS10 ribosomal protein S10 -0.015366
TNNC1 troponin C type 1 (slow) -0.015073
RPS21 ribosomal protein S21 -0.0149825
RPL37 ribosomal protein L37 -0.0148847
RPL13A ribosomal protein L13a -0.0148779
PRMT2 protein arginine methyltransferase 2 -0.0146671
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0146417
HMGB1 high mobility group box 1 -0.0144203
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0143627
LASP1 LIM and SH3 protein 1 -0.0143582
RIGI RNA sensor RIG-I -0.0143083
ENO1 enolase 1, (alpha) -0.0143009
RPS23 ribosomal protein S23 -0.0142672
FAM162A family with sequence similarity 162, member A -0.0139408
MARCHF6 membrane associated ring-CH-type finger 6 -0.0139342
ISG15 ISG15 ubiquitin-like modifier -0.0139326