| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMYD3 | SET and MYND domain containing 3 | 0.0740764 |
| ATM | ATM serine/threonine kinase | 0.0676282 |
| SQSTM1 | sequestosome 1 | 0.0660499 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0589 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0546102 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0537363 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0536174 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0533409 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0525126 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0514306 |
| DNER | delta/notch-like EGF repeat containing | 0.0513975 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0496606 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0470316 |
| PRKCA | protein kinase C, alpha | 0.0465637 |
| GOLGA4 | golgin A4 | 0.0454798 |
| FNIP1 | folliculin interacting protein 1 | 0.0445227 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0439067 |
| GPC6 | glypican 6 | 0.0439046 |
| INTS6 | integrator complex subunit 6 | 0.0438437 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0438289 |
| SVIL | supervillin | 0.0425613 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0424816 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0412602 |
| HSPA8 | heat shock 70kDa protein 8 | 0.040529 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0401664 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0398223 |
| AHR | aryl hydrocarbon receptor | 0.0398063 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0392906 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0391089 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.037966 |
| ATXN1 | ataxin 1 | 0.0379604 |
| CANX | calnexin | 0.03759 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0370913 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0362008 |
| FRYL | FRY-like | 0.0361088 |
| EEA1 | early endosome antigen 1 | 0.0356025 |
| SMAD3 | SMAD family member 3 | 0.0352548 |
| OXSR1 | oxidative stress responsive 1 | 0.0345146 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0341233 |
| NBEA | neurobeachin | 0.0328373 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.032774 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0327126 |
| YAP1 | Yes-associated protein 1 | 0.0325726 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0319688 |
| CCDC91 | coiled-coil domain containing 91 | 0.0319581 |
| FMNL2 | formin-like 2 | 0.0317836 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0314902 |
| RBM39 | RNA binding motif protein 39 | 0.031214 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0302626 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0299252 |
| HMGA2 | high mobility group AT-hook 2 | 0.0296037 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0295544 |
| ANXA1 | annexin A1 | 0.0291032 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0289724 |
| PHF3 | PHD finger protein 3 | 0.0283712 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0282454 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0282086 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0281692 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0276668 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.0267701 |
| OSMR | oncostatin M receptor | 0.026418 |
| MATR3 | matrin 3 | 0.0263694 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0263585 |
| MYO9A | myosin IXA | 0.0261678 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0260407 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0260218 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0257697 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0257336 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0256487 |
| CLTC | clathrin, heavy chain (Hc) | 0.0254169 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0252112 |
| RSRP1 | arginine/serine-rich protein 1 | 0.025125 |
| CREBRF | CREB3 regulatory factor | 0.0248031 |
| CENPP | centromere protein P | 0.0247503 |
| AFF4 | AF4/FMR2 family, member 4 | 0.024702 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0246786 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0244816 |
| FAM13A | family with sequence similarity 13, member A | 0.0244653 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0241856 |
| IGF2 | insulin-like growth factor 2 | 0.0238819 |
| COMMD10 | COMM domain containing 10 | 0.0237292 |
| RDX | radixin | 0.0236977 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0235023 |
| GOLGB1 | golgin B1 | 0.0233488 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0233115 |
| TLE4 | transducin-like enhancer of split 4 | 0.023126 |
| CALU | calumenin | 0.0230438 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0230028 |
| CCNH | cyclin H | 0.022844 |
| CLINT1 | clathrin interactor 1 | 0.0227998 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.022524 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.0221927 |
| PAPOLA | poly(A) polymerase alpha | 0.0221638 |
| CTR9 | CTR9, Paf1/RNA polymerase II complex component | 0.0221439 |
| STXBP1 | syntaxin binding protein 1 | 0.0219986 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0216739 |
| RNF213 | ring finger protein 213 | 0.0216724 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0215614 |
| NPAT | nuclear protein, ataxia-telangiectasia locus | 0.0214453 |
| GLG1 | golgi glycoprotein 1 | 0.0213297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.208971 |
| VIM | vimentin | -0.125452 |
| TMSB10 | thymosin beta 10 | -0.118481 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0807489 |
| POTEF | POTE ankyrin domain family, member F | -0.0745987 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0655439 |
| PTMA | prothymosin, alpha | -0.0642576 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0534447 |
| CD44 | CD44 molecule (Indian blood group) | -0.0526252 |
| ANGPTL4 | angiopoietin-like 4 | -0.0516465 |
| PKM | pyruvate kinase, muscle | -0.0476062 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.046449 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0438172 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0426755 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0417769 |
| LDHA | lactate dehydrogenase A | -0.0416426 |
| B2M | beta-2-microglobulin | -0.0412951 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0411619 |
| ANXA2 | annexin A2 | -0.0410142 |
| PRSS23 | protease, serine, 23 | -0.0405624 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0404412 |
| RTN4 | reticulon 4 | -0.0389622 |
| ENO1 | enolase 1, (alpha) | -0.0378645 |
| SEPTIN7 | septin 7 | -0.0378272 |
| TPM4 | tropomyosin 4 | -0.0369152 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0366408 |
| JMJD1C | jumonji domain containing 1C | -0.0360194 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0351694 |
| MAP1B | microtubule-associated protein 1B | -0.034739 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0340136 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0335705 |
| PGK1 | phosphoglycerate kinase 1 | -0.0326903 |
| RPS23 | ribosomal protein S23 | -0.0326563 |
| RBM25 | RNA binding motif protein 25 | -0.0319887 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0318855 |
| ACTG1 | actin gamma 1 | -0.0318056 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0317003 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0315384 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0314545 |
| ERBIN | erbb2 interacting protein | -0.0313666 |
| S100A6 | S100 calcium binding protein A6 | -0.0311075 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0303546 |
| MT2A | metallothionein 2A | -0.0300033 |
| DEK | DEK proto-oncogene | -0.0296646 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0292452 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0292152 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0290869 |
| PFN1 | profilin 1 | -0.0289452 |
| HLA-A | major histocompatibility complex, class I, A | -0.0287996 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0284504 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0282081 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0282076 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0279234 |
| FOSL1 | FOS-like antigen 1 | -0.0275345 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0272672 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0271789 |
| ACER3 | alkaline ceramidase 3 | -0.0268893 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0267523 |
| SETD5 | SET domain containing 5 | -0.026419 |
| BPTF | bromodomain PHD finger transcription factor | -0.0262009 |
| CDYL | chromodomain protein, Y-like | -0.0258914 |
| RPS25 | ribosomal protein S25 | -0.0254521 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0251746 |
| HMGA1 | high mobility group AT-hook 1 | -0.0251076 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0250823 |
| S100A9 | S100 calcium binding protein A9 | -0.0250654 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0246544 |
| PARD3 | par-3 family cell polarity regulator | -0.0246305 |
| PODXL | podocalyxin-like | -0.0244884 |
| CCDC50 | coiled-coil domain containing 50 | -0.0244026 |
| MSN | moesin | -0.0241961 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0241159 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0239615 |
| ATP13A3 | ATPase type 13A3 | -0.0239601 |
| YBX3 | Y box binding protein 3 | -0.023601 |
| RPL35A | ribosomal protein L35a | -0.0234836 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0233127 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0231328 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.0230778 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.022837 |
| TPX2 | TPX2, microtubule-associated | -0.0227985 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0226532 |
| GPATCH2L | G patch domain containing 2-like | -0.0224661 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0223604 |
| TMEM161B | transmembrane protein 161B | -0.0223059 |
| TXN2 | thioredoxin 2 | -0.0222971 |
| H1-0 | H1.0 linker histone | -0.0222955 |
| SDC4 | syndecan 4 | -0.0221623 |
| RPL11 | ribosomal protein L11 | -0.0220898 |
| WWC1 | WW and C2 domain containing 1 | -0.0219046 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0218395 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0217979 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0217915 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0216211 |
| LDLR | low density lipoprotein receptor | -0.0215143 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0215129 |
| DENND5B | DENN/MADD domain containing 5B | -0.0213799 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.0211607 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.020989 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0208727 |
