| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.12538 |
| SQSTM1 | sequestosome 1 | 0.118223 |
| HMGA2 | high mobility group AT-hook 2 | 0.110173 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.104184 |
| NRG1 | neuregulin 1 | 0.0915739 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.087432 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0798762 |
| RAI14 | retinoic acid induced 14 | 0.0741099 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0713768 |
| STC2 | stanniocalcin 2 | 0.0689112 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0643082 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0628381 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0625964 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.059298 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0566834 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0565731 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0559701 |
| EFNA5 | ephrin-A5 | 0.0546688 |
| SFTPA2 | surfactant protein A2 | 0.0515198 |
| INTS6 | integrator complex subunit 6 | 0.0511799 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.050223 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0448003 |
| AEBP2 | AE binding protein 2 | 0.0443906 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0439562 |
| GPC6 | glypican 6 | 0.0412639 |
| PALLD | palladin, cytoskeletal associated protein | 0.0411893 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0410509 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0405137 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.040033 |
| CADM1 | cell adhesion molecule 1 | 0.0393346 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0392334 |
| RASAL2 | RAS protein activator like 2 | 0.0379135 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0374755 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0366733 |
| CANX | calnexin | 0.0358548 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0346802 |
| RND3 | Rho family GTPase 3 | 0.0344339 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0339436 |
| GOLGB1 | golgin B1 | 0.0337275 |
| LOX | lysyl oxidase | 0.0335827 |
| PLIN2 | perilipin 2 | 0.0334174 |
| MMP13 | matrix metallopeptidase 13 | 0.0334094 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0330493 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0329401 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0329285 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 0.0324513 |
| LYST | lysosomal trafficking regulator | 0.031625 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0310758 |
| FTL | ferritin, light polypeptide | 0.0309577 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.030031 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0299098 |
| EMP1 | epithelial membrane protein 1 | 0.0289623 |
| SIRT1 | sirtuin 1 | 0.0288968 |
| MYOF | myoferlin | 0.0287718 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0284673 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0284657 |
| FBN1 | fibrillin 1 | 0.0283085 |
| ATF3 | activating transcription factor 3 | 0.0282947 |
| TNS3 | tensin 3 | 0.0277862 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0269969 |
| LRRC23 | leucine rich repeat containing 23 | 0.0268233 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0267385 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0265693 |
| FNIP1 | folliculin interacting protein 1 | 0.0255169 |
| EGFR | epidermal growth factor receptor | 0.0252322 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0250847 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 0.0250022 |
| AHI1 | Abelson helper integration site 1 | 0.0248703 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0248093 |
| MTSS1 | metastasis suppressor 1 | 0.0246775 |
| POU2F2 | POU class 2 homeobox 2 | 0.0246586 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0242924 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0242315 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0238421 |
| NDRG1 | N-myc downstream regulated 1 | 0.0237358 |
| CUX1 | cut-like homeobox 1 | 0.0231804 |
| CTSB | cathepsin B | 0.0230521 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0229288 |
| CFB | complement factor B | 0.0228114 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0228086 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0225203 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0223202 |
| ATF6 | activating transcription factor 6 | 0.0223188 |
| GPR176 | G protein-coupled receptor 176 | 0.0222398 |
| RANBP17 | RAN binding protein 17 | 0.022224 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0220102 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0218346 |
| DSTN | destrin (actin depolymerizing factor) | 0.0218307 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0215554 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.0215282 |
| NTN4 | netrin 4 | 0.0214305 |
| FAM107B | family with sequence similarity 107, member B | 0.0214143 |
| HLA-E | major histocompatibility complex, class I, E | 0.0213387 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0213357 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0212121 |
| ABR | active BCR-related | 0.0210676 |
| LMNA | lamin A/C | 0.0208792 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0208702 |
| RASEF | RAS and EF-hand domain containing | 0.0208415 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0205789 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.217447 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.185636 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.134774 |
| MT2A | metallothionein 2A | -0.122044 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0851225 |
| CENPF | centromere protein F, 350/400kDa | -0.0824249 |
| TMEM156 | transmembrane protein 156 | -0.0751676 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0736497 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0645027 |
| OGA | O-GlcNAcase | -0.0632095 |
| SMOX | spermine oxidase | -0.060911 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0591585 |
| RNF145 | ring finger protein 145 | -0.0563208 |
| NEK7 | NIMA-related kinase 7 | -0.0536272 |
| MKI67 | marker of proliferation Ki-67 | -0.0535158 |
| RTN4 | reticulon 4 | -0.0534737 |
| AHR | aryl hydrocarbon receptor | -0.0525299 |
| RBM39 | RNA binding motif protein 39 | -0.052392 |
| PELO | pelota homolog (Drosophila) | -0.0521628 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.051863 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.051091 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0505648 |
| FNBP1 | formin binding protein 1 | -0.0495468 |
| RBM25 | RNA binding motif protein 25 | -0.0491942 |
| TMSB10 | thymosin beta 10 | -0.0490673 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0474964 |
| S100A6 | S100 calcium binding protein A6 | -0.0470454 |
| ZNF292 | zinc finger protein 292 | -0.0461299 |
| ETNK1 | ethanolamine kinase 1 | -0.0455756 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0438957 |
| PTK2 | protein tyrosine kinase 2 | -0.0438212 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0429353 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0424064 |
| ANLN | anillin, actin binding protein | -0.0422195 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0421854 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0421776 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0420169 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0414391 |
| XPO1 | exportin 1 | -0.0412064 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0409306 |
| OSMR | oncostatin M receptor | -0.0407455 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0407126 |
| ETV1 | ets variant 1 | -0.0405669 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0404409 |
| WAC | WW domain containing adaptor with coiled-coil | -0.039875 |
| CD44 | CD44 molecule (Indian blood group) | -0.0397346 |
| VCL | vinculin | -0.0396538 |
| DUSP5 | dual specificity phosphatase 5 | -0.0394534 |
| MIS18BP1 | MIS18 binding protein 1 | -0.039261 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0392353 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0390295 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0387258 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0384844 |
| EREG | epiregulin | -0.0381228 |
| SEPTIN7 | septin 7 | -0.0380723 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.03771 |
| MAP1B | microtubule-associated protein 1B | -0.0375757 |
| FN1 | fibronectin 1 | -0.0373881 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0373259 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0370311 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.036867 |
| PTMA | prothymosin, alpha | -0.0367312 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0366524 |
| TXNIP | thioredoxin interacting protein | -0.0365061 |
| NRP1 | neuropilin 1 | -0.0360936 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0360486 |
| NUP58 | nucleoporin 58 | -0.0360116 |
| TFG | TRK-fused gene | -0.0352638 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.035057 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0346979 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0341773 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0341598 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0340527 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0337769 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0336128 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0333174 |
| PKM | pyruvate kinase, muscle | -0.0332584 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0331426 |
| SMYD3 | SET and MYND domain containing 3 | -0.03269 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0324328 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0324231 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0322514 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0321175 |
| VIM | vimentin | -0.0320989 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0317909 |
| SRPK2 | SRSF protein kinase 2 | -0.0316786 |
| COG5 | component of oligomeric golgi complex 5 | -0.0315854 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | -0.0314688 |
| CAB39 | calcium binding protein 39 | -0.0314648 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0314448 |
| ACTN4 | actinin, alpha 4 | -0.031249 |
| ANKRD11 | ankyrin repeat domain 11 | -0.031153 |
| ITGB5 | integrin, beta 5 | -0.0311472 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0309433 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0307302 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0306069 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0301444 |
| TXNRD1 | thioredoxin reductase 1 | -0.0300451 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0298689 |
| RPS6 | ribosomal protein S6 | -0.0297577 |
