| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.156489 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.127827 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0979034 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0911548 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0906584 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0819158 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0812377 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0785438 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0782905 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0765537 |
| GOLGB1 | golgin B1 | 0.0723811 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0703665 |
| GOLGA4 | golgin A4 | 0.0696988 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0690679 |
| MYO1E | myosin IE | 0.0685115 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0678713 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0674308 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0644409 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.063609 |
| BCL2L1 | BCL2-like 1 | 0.0627595 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0624015 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0614747 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0603618 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0586152 |
| YAP1 | Yes-associated protein 1 | 0.0579197 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0559666 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0559585 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0551533 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0539812 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0538969 |
| SMAD3 | SMAD family member 3 | 0.0536209 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0534424 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0531063 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0528677 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0513941 |
| SNX9 | sorting nexin 9 | 0.0510751 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0501032 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0497554 |
| DSPP | dentin sialophosphoprotein | 0.0496235 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0483751 |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | 0.0481054 |
| RPS2 | ribosomal protein S2 | 0.0475798 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0474957 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0470457 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0466659 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0458964 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0453373 |
| VCL | vinculin | 0.0450362 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0446374 |
| CDK13 | cyclin-dependent kinase 13 | 0.0445726 |
| GPHN | gephyrin | 0.0444969 |
| FAM107B | family with sequence similarity 107, member B | 0.0444327 |
| TMF1 | TATA element modulatory factor 1 | 0.0441799 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.043801 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0437519 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.043676 |
| NRP1 | neuropilin 1 | 0.0430291 |
| RCOR1 | REST corepressor 1 | 0.0428457 |
| TJP1 | tight junction protein 1 | 0.042575 |
| PCBP2 | poly(rC) binding protein 2 | 0.042284 |
| SLTM | SAFB-like, transcription modulator | 0.0412195 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0406101 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0401452 |
| FAT1 | FAT atypical cadherin 1 | 0.0401126 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0398275 |
| UBC | ubiquitin C | 0.0398057 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0397952 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0396241 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0393957 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0392209 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0391286 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.038388 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0382504 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.037992 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0375451 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0375349 |
| RBM39 | RNA binding motif protein 39 | 0.0372516 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0371709 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0371685 |
| EHBP1 | EH domain binding protein 1 | 0.0367924 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0364869 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0362382 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0359565 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0358378 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0357399 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0353568 |
| RPLP0 | ribosomal protein, large, P0 | 0.035214 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0351728 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0347526 |
| ERBIN | erbb2 interacting protein | 0.0341577 |
| KRT18 | keratin 18, type I | 0.034118 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0341177 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0337352 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0331554 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0330644 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0326846 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0325019 |
| JMJD1C | jumonji domain containing 1C | 0.0323003 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0321367 |
| ITGA6 | integrin, alpha 6 | 0.0319899 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0947976 |
| PTMA | prothymosin, alpha | -0.087221 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0591437 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0565516 |
| TMSB10 | thymosin beta 10 | -0.0543749 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0421085 |
| FTL | ferritin, light polypeptide | -0.0407537 |
| ACTN4 | actinin, alpha 4 | -0.0386076 |
| PRELID2 | PRELI domain containing 2 | -0.037393 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0367976 |
| RIGI | RNA sensor RIG-I | -0.0361978 |
| MX2 | MX dynamin-like GTPase 2 | -0.0361132 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.031872 |
| B2M | beta-2-microglobulin | -0.0312541 |
| RNF213 | ring finger protein 213 | -0.0310839 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0306681 |
| PLAUR | plasminogen activator, urokinase receptor | -0.029485 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.028981 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0282163 |
| RTN4 | reticulon 4 | -0.0265606 |
| IER3 | immediate early response 3 | -0.026265 |
| ZNRF3 | zinc and ring finger 3 | -0.025139 |
| RPL35A | ribosomal protein L35a | -0.0249621 |
| CST3 | cystatin C | -0.0249371 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0240718 |
| RNF149 | ring finger protein 149 | -0.02368 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0235722 |
| RPS19 | ribosomal protein S19 | -0.0228473 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0227565 |
| SP100 | SP100 nuclear antigen | -0.0226765 |
| RNF43 | ring finger protein 43 | -0.0225816 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0225756 |
| RPL23 | ribosomal protein L23 | -0.0225403 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.021884 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0216042 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0212691 |
| MX1 | MX dynamin-like GTPase 1 | -0.0212657 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0212495 |
| KRT8 | keratin 8, type II | -0.0202115 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0200112 |
| CLDN4 | claudin 4 | -0.0194694 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0189656 |
| ITGB4 | integrin, beta 4 | -0.0187562 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0186702 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0182104 |
| SNRK | SNF related kinase | -0.0178523 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0178072 |
| S100A10 | S100 calcium binding protein A10 | -0.0175914 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0175768 |
| PMP22 | peripheral myelin protein 22 | -0.017482 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0174661 |
| ADAR | adenosine deaminase, RNA-specific | -0.0173988 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.017364 |
| PGK1 | phosphoglycerate kinase 1 | -0.0171783 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0167305 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0166639 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0164909 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0164884 |
| TMEM123 | transmembrane protein 123 | -0.0164647 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0160168 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0159398 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0156123 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0153519 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0152264 |
| HOXB3 | homeobox B3 | -0.0151455 |
| HLA-B | major histocompatibility complex, class I, B | -0.0149926 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0149414 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0149027 |
| IRF1 | interferon regulatory factor 1 | -0.0148931 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0147689 |
| RRBP1 | ribosome binding protein 1 | -0.0145168 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | -0.0142767 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0142582 |
| WDR45B | WD repeat domain 45B | -0.0142509 |
| GPSM2 | G-protein signaling modulator 2 | -0.0142075 |
| TRIM56 | tripartite motif containing 56 | -0.0141988 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0141448 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0140463 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0140292 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0139248 |
| VIM | vimentin | -0.0138382 |
| THOC2 | THO complex 2 | -0.0137798 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0137547 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0136769 |
| OGFR | opioid growth factor receptor | -0.0134463 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0133926 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0132889 |
| LRRC40 | leucine rich repeat containing 40 | -0.0132607 |
| RTF2 | replication termination factor 2 | -0.0129992 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0128688 |
| RBM25 | RNA binding motif protein 25 | -0.0128061 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0128013 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | -0.0127365 |
| APOL6 | apolipoprotein L, 6 | -0.0127052 |
| PHF21A | PHD finger protein 21A | -0.0126851 |
| LAMB3 | laminin, beta 3 | -0.0126162 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0126151 |
| TPM4 | tropomyosin 4 | -0.0126115 |
| KLK10 | kallikrein-related peptidase 10 | -0.0125139 |
| NLRC5 | NLR family, CARD domain containing 5 | -0.0124354 |
