| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0870159 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0736869 |
| RPS2 | ribosomal protein S2 | 0.0734324 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0702504 |
| ATXN1 | ataxin 1 | 0.0642129 |
| EGFR | epidermal growth factor receptor | 0.0565945 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0541915 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0518052 |
| RPL3 | ribosomal protein L3 | 0.0493596 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0476833 |
| LAMA4 | laminin, alpha 4 | 0.0470921 |
| RCOR1 | REST corepressor 1 | 0.0470847 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.046647 |
| SGMS2 | sphingomyelin synthase 2 | 0.0420792 |
| NUP50 | nucleoporin 50kDa | 0.0419082 |
| ACTG1 | actin gamma 1 | 0.041022 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0400066 |
| NDRG1 | N-myc downstream regulated 1 | 0.0389771 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0383423 |
| SNX9 | sorting nexin 9 | 0.0360305 |
| FHL2 | four and a half LIM domains 2 | 0.0352942 |
| MYO5B | myosin VB | 0.0348492 |
| EFNB2 | ephrin-B2 | 0.0323145 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0320334 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0312601 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0308194 |
| RPS18 | ribosomal protein S18 | 0.0296611 |
| POTEF | POTE ankyrin domain family, member F | 0.0295464 |
| YAP1 | Yes-associated protein 1 | 0.026826 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0265893 |
| LAMC2 | laminin, gamma 2 | 0.026125 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0257337 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0252307 |
| CPOX | coproporphyrinogen oxidase | 0.0247169 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0234863 |
| PCBP2 | poly(rC) binding protein 2 | 0.023437 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0219126 |
| SEPTIN9 | septin 9 | 0.0217783 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0217642 |
| SMAD3 | SMAD family member 3 | 0.0214768 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0211248 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.020834 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.0206889 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0200573 |
| SQSTM1 | sequestosome 1 | 0.01935 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.019221 |
| BRD2 | bromodomain containing 2 | 0.0191875 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.0191708 |
| HOMER1 | homer scaffolding protein 1 | 0.0190494 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0189223 |
| FAT1 | FAT atypical cadherin 1 | 0.0187489 |
| CDCP1 | CUB domain containing protein 1 | 0.018723 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0187157 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0183883 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0181858 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0181064 |
| PAPOLA | poly(A) polymerase alpha | 0.017988 |
| HMGA2 | high mobility group AT-hook 2 | 0.0175177 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0171907 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0170335 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0169364 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0169265 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.016919 |
| CD44 | CD44 molecule (Indian blood group) | 0.0168601 |
| ZNRF3 | zinc and ring finger 3 | 0.0168386 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0166981 |
| SPAG9 | sperm associated antigen 9 | 0.0166846 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0165964 |
| FAM107B | family with sequence similarity 107, member B | 0.0165961 |
| RPL21 | ribosomal protein L21 | 0.0164545 |
| COPA | coatomer protein complex, subunit alpha | 0.0161116 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0161024 |
| WWOX | WW domain containing oxidoreductase | 0.0160618 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0159208 |
| IRS2 | insulin receptor substrate 2 | 0.0158686 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0157016 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0154714 |
| VEGFA | vascular endothelial growth factor A | 0.0153507 |
| GLCCI1 | glucocorticoid induced 1 | 0.0151579 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0151215 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0150983 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0150876 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0150872 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0149648 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0148906 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0148225 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0147906 |
| TPM3 | tropomyosin 3 | 0.0147842 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0147089 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.014703 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0146952 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0146827 |
| ASPH | aspartate beta-hydroxylase | 0.0146127 |
| SVIL | supervillin | 0.0144825 |
| MCL1 | myeloid cell leukemia 1 | 0.0144011 |
| DSPP | dentin sialophosphoprotein | 0.0143952 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0143727 |
| NAV2 | neuron navigator 2 | 0.0142945 |
| VMP1 | vacuole membrane protein 1 | 0.0142665 |
| CTSB | cathepsin B | 0.0142003 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.204771 |
| PTMA | prothymosin, alpha | -0.187115 |
| TMSB10 | thymosin beta 10 | -0.11584 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.113794 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.111606 |
| FERMT1 | fermitin family member 1 | -0.0977644 |
| OXR1 | oxidation resistance 1 | -0.0884217 |
| HDAC2 | histone deacetylase 2 | -0.0835046 |
| RPS24 | ribosomal protein S24 | -0.0802911 |
| RBM25 | RNA binding motif protein 25 | -0.0755026 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0722196 |
| SERINC5 | serine incorporator 5 | -0.0720335 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0640486 |
| RPLP1 | ribosomal protein, large, P1 | -0.0612204 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.060548 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.0573361 |
| RPL35A | ribosomal protein L35a | -0.0573073 |
| MTAP | methylthioadenosine phosphorylase | -0.0559031 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0554266 |
| ANXA1 | annexin A1 | -0.0533945 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0502462 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0500468 |
| RPL32 | ribosomal protein L32 | -0.0490152 |
| CD9 | CD9 molecule | -0.0486672 |
| LAMB3 | laminin, beta 3 | -0.0478069 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0467117 |
| MT2A | metallothionein 2A | -0.0442945 |
| NEK7 | NIMA-related kinase 7 | -0.0426143 |
| AOPEP | aminopeptidase O (putative) | -0.0426039 |
| RAD51B | RAD51 paralog B | -0.0423027 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0421934 |
| RPS29 | ribosomal protein S29 | -0.0405608 |
| RPS19 | ribosomal protein S19 | -0.0385328 |
| THOC2 | THO complex 2 | -0.0384096 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.037581 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0364218 |
| RPL11 | ribosomal protein L11 | -0.0361849 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0361561 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0359206 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0340034 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0337266 |
| RPL12 | ribosomal protein L12 | -0.0328459 |
| EZR | ezrin | -0.0325769 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0322886 |
| PHF14 | PHD finger protein 14 | -0.0321226 |
| RPS4X | ribosomal protein S4, X-linked | -0.0319372 |
| AREG | amphiregulin | -0.0316464 |
| FHIT | fragile histidine triad | -0.0314789 |
| GPHN | gephyrin | -0.0309459 |
| KRT18 | keratin 18, type I | -0.0307345 |
| IER3 | immediate early response 3 | -0.030648 |
| NEMF | nuclear export mediator factor | -0.0304023 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0302022 |
| UBE3C | ubiquitin protein ligase E3C | -0.0297731 |
| RPS3 | ribosomal protein S3 | -0.0297238 |
| DENND1A | DENN/MADD domain containing 1A | -0.0296378 |
| CUX1 | cut-like homeobox 1 | -0.0295643 |
| VCL | vinculin | -0.029495 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0293788 |
| S100A11 | S100 calcium binding protein A11 | -0.0288887 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0288208 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0285118 |
| TUBB | tubulin, beta class I | -0.0281614 |
| RPL34 | ribosomal protein L34 | -0.0275873 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0275395 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0273824 |
| FOSL1 | FOS-like antigen 1 | -0.0272168 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0271201 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0270411 |
| SMYD3 | SET and MYND domain containing 3 | -0.0269136 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267484 |
| RPL7A | ribosomal protein L7a | -0.0267155 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0264836 |
| RPS21 | ribosomal protein S21 | -0.0261131 |
| PGK1 | phosphoglycerate kinase 1 | -0.0261084 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0260193 |
| S100A6 | S100 calcium binding protein A6 | -0.0259812 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0258519 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0258375 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0256955 |
| ANXA2 | annexin A2 | -0.0255682 |
| FMNL2 | formin-like 2 | -0.0255601 |
| COG5 | component of oligomeric golgi complex 5 | -0.0251935 |
| KRT8 | keratin 8, type II | -0.025093 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0249858 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0246681 |
| CCND1 | cyclin D1 | -0.0245605 |
| PERP | PERP, TP53 apoptosis effector | -0.0244577 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.024348 |
| RPLP2 | ribosomal protein, large, P2 | -0.024266 |
| RPL23 | ribosomal protein L23 | -0.0242215 |
| LMO7 | LIM domain 7 | -0.0240362 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0239838 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0238944 |
| RPS13 | ribosomal protein S13 | -0.0236331 |
| RPLP0 | ribosomal protein, large, P0 | -0.0236221 |
| RPS6 | ribosomal protein S6 | -0.0235196 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0232786 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0232472 |
| RPL36 | ribosomal protein L36 | -0.023242 |
