| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.189742 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.162824 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.1406 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.129493 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0968985 |
| ASPH | aspartate beta-hydroxylase | 0.0916701 |
| RPS6 | ribosomal protein S6 | 0.0897143 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0890285 |
| SPATA13 | spermatogenesis associated 13 | 0.088787 |
| DST | dystonin | 0.0865893 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0809571 |
| RPS2 | ribosomal protein S2 | 0.0795659 |
| LMO7 | LIM domain 7 | 0.076829 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0755379 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0731017 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0719605 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0711506 |
| RPL26 | ribosomal protein L26 | 0.0696145 |
| PLEC | plectin | 0.0691262 |
| FRMD5 | FERM domain containing 5 | 0.0680231 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0679438 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0642732 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0639911 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.061679 |
| RPL7 | ribosomal protein L7 | 0.0610043 |
| DSPP | dentin sialophosphoprotein | 0.0602052 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0601019 |
| RPS8 | ribosomal protein S8 | 0.0589889 |
| RPS12 | ribosomal protein S12 | 0.0587542 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0557125 |
| CCND1 | cyclin D1 | 0.0538275 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0517815 |
| YAP1 | Yes-associated protein 1 | 0.051279 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0507262 |
| EMP1 | epithelial membrane protein 1 | 0.0491529 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0490192 |
| SERINC5 | serine incorporator 5 | 0.0490133 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0488404 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0481416 |
| SYT1 | synaptotagmin I | 0.0472065 |
| ITGA6 | integrin, alpha 6 | 0.0471709 |
| MT2A | metallothionein 2A | 0.0463384 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0458265 |
| RPL12 | ribosomal protein L12 | 0.0456432 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0448558 |
| CTSB | cathepsin B | 0.0446878 |
| EZR | ezrin | 0.0442204 |
| SH3D19 | SH3 domain containing 19 | 0.0431757 |
| ATXN1 | ataxin 1 | 0.0421302 |
| SVIL | supervillin | 0.0415415 |
| CDK6 | cyclin-dependent kinase 6 | 0.0412173 |
| SEPTIN9 | septin 9 | 0.0406517 |
| CDCP1 | CUB domain containing protein 1 | 0.0398628 |
| RPS13 | ribosomal protein S13 | 0.0394942 |
| MSN | moesin | 0.0394314 |
| SKAP1 | src kinase associated phosphoprotein 1 | 0.0382271 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0380217 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0378955 |
| NPAS2 | neuronal PAS domain protein 2 | 0.037857 |
| TNS3 | tensin 3 | 0.0376063 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0368189 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0367294 |
| RPL3 | ribosomal protein L3 | 0.0365498 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0364126 |
| GOLGB1 | golgin B1 | 0.0360314 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0354888 |
| RPS17 | ribosomal protein S17 | 0.0351756 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0351388 |
| RPS23 | ribosomal protein S23 | 0.0349808 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0348084 |
| MYO1E | myosin IE | 0.0343952 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0341089 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0337245 |
| SLC38A2 | solute carrier family 38, member 2 | 0.033442 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0329895 |
| DUSP6 | dual specificity phosphatase 6 | 0.0329828 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.032849 |
| IPO7 | importin 7 | 0.0327194 |
| RACK1 | receptor for activated C kinase 1 | 0.0324862 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0323435 |
| RPL37 | ribosomal protein L37 | 0.0322976 |
| ACTN1 | actinin, alpha 1 | 0.0322248 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.032056 |
| SNX9 | sorting nexin 9 | 0.031493 |
| RPS18 | ribosomal protein S18 | 0.0313996 |
| NDRG1 | N-myc downstream regulated 1 | 0.0313029 |
| EHBP1 | EH domain binding protein 1 | 0.031168 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0310996 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0310842 |
| COBL | cordon-bleu WH2 repeat protein | 0.0309539 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.03084 |
| YBX3 | Y box binding protein 3 | 0.0307169 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0305332 |
| SMAD3 | SMAD family member 3 | 0.0304194 |
| RPL5 | ribosomal protein L5 | 0.0303326 |
| HMGA1 | high mobility group AT-hook 1 | 0.0300403 |
| MCC | mutated in colorectal cancers | 0.03004 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0300373 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0299641 |
| RPS3 | ribosomal protein S3 | 0.0295371 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DIAPH3 | diaphanous-related formin 3 | -0.0671364 |
| ANLN | anillin, actin binding protein | -0.0608827 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0551652 |
| PTMA | prothymosin, alpha | -0.0525208 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0501311 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0484804 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0449751 |
| CDH13 | cadherin 13 | -0.0344738 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0335218 |
| SYK | spleen tyrosine kinase | -0.0309372 |
| VCL | vinculin | -0.0302592 |
| HMGB1 | high mobility group box 1 | -0.0295255 |
| MKI67 | marker of proliferation Ki-67 | -0.0292805 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0282832 |
| TUBB | tubulin, beta class I | -0.0273709 |
| KRT8 | keratin 8, type II | -0.0267357 |
| TMSB10 | thymosin beta 10 | -0.0262677 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.025691 |
| OGA | O-GlcNAcase | -0.0253895 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0250948 |
| RRM2 | ribonucleotide reductase M2 | -0.0250503 |
| HMGB2 | high mobility group box 2 | -0.0249778 |
| PGK1 | phosphoglycerate kinase 1 | -0.0243812 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0240694 |
| GNAS | GNAS complex locus | -0.0239953 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0239859 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.023916 |
| TPX2 | TPX2, microtubule-associated | -0.0238753 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0238053 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0237244 |
| TFRC | transferrin receptor | -0.0229122 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0219448 |
| H1-0 | H1.0 linker histone | -0.0216923 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0216783 |
| CENPF | centromere protein F, 350/400kDa | -0.0211058 |
| ECT2 | epithelial cell transforming 2 | -0.0207423 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0207267 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0206041 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0205523 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0205138 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0203866 |
| XPO1 | exportin 1 | -0.0203637 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.020083 |
| SGO2 | shugoshin 2 | -0.0199668 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0198324 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0197925 |
| IER3 | immediate early response 3 | -0.0196918 |
| COG5 | component of oligomeric golgi complex 5 | -0.0193095 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0192828 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.0192107 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0188516 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0187696 |
| TMEM41B | transmembrane protein 41B | -0.0187301 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0186955 |
| NHSL1 | NHS-like 1 | -0.0186436 |
| RUNX2 | runt-related transcription factor 2 | -0.0185985 |
| CENPE | centromere protein E, 312kDa | -0.0183486 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.017943 |
| CDK8 | cyclin-dependent kinase 8 | -0.0178577 |
| ARF4 | ADP-ribosylation factor 4 | -0.0178164 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0175848 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0173908 |
| INTS6 | integrator complex subunit 6 | -0.0173237 |
| MAP4 | microtubule-associated protein 4 | -0.0171054 |
| FANCI | Fanconi anemia, complementation group I | -0.0170969 |
| DEK | DEK proto-oncogene | -0.0170795 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0170523 |
| KIF4A | kinesin family member 4A | -0.0170194 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0169962 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0169566 |
| WDR45B | WD repeat domain 45B | -0.0168457 |
| CEP95 | centrosomal protein 95kDa | -0.0167048 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0165272 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0164543 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0164507 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0162421 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0162231 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0162003 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0160967 |
| FOSL1 | FOS-like antigen 1 | -0.0160706 |
| MTF2 | metal response element binding transcription factor 2 | -0.0160603 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0160373 |
| ABLIM1 | actin binding LIM protein 1 | -0.0160191 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0159537 |
| TNNC1 | troponin C type 1 (slow) | -0.0158745 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0158526 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0155658 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.015523 |
| ZNF292 | zinc finger protein 292 | -0.0152147 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0151863 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0151857 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0150653 |
| THOC2 | THO complex 2 | -0.0150082 |
| HELLS | helicase, lymphoid-specific | -0.0149206 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0148679 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0148157 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0147753 |
| CENPK | centromere protein K | -0.0147624 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0146298 |
| MAP1B | microtubule-associated protein 1B | -0.0145772 |
