| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.333506 |
| FN1 | fibronectin 1 | 0.140646 |
| NDRG1 | N-myc downstream regulated 1 | 0.0914581 |
| CD44 | CD44 molecule (Indian blood group) | 0.0849025 |
| MMP1 | matrix metallopeptidase 1 | 0.0748109 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0713485 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.061086 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0590154 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0546402 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0534407 |
| HMGA2 | high mobility group AT-hook 2 | 0.0527983 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0504439 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0483049 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0456149 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0427314 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0421578 |
| INHBA | inhibin, beta A | 0.042121 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0389675 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0388388 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0371695 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0365943 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0355725 |
| MCL1 | myeloid cell leukemia 1 | 0.0354132 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0351568 |
| FMNL2 | formin-like 2 | 0.034535 |
| CALU | calumenin | 0.033288 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.032737 |
| LOX | lysyl oxidase | 0.0327254 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0310349 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0304558 |
| EMP1 | epithelial membrane protein 1 | 0.0290719 |
| FAM13A | family with sequence similarity 13, member A | 0.0288709 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.028447 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0281158 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0280137 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0273738 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0273421 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0270637 |
| CLTC | clathrin, heavy chain (Hc) | 0.0266014 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0263445 |
| GOLGB1 | golgin B1 | 0.026303 |
| ANO6 | anoctamin 6 | 0.0259794 |
| GOLGA4 | golgin A4 | 0.0255376 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0254068 |
| RUNX1 | runt-related transcription factor 1 | 0.024992 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0248834 |
| HDLBP | high density lipoprotein binding protein | 0.0245668 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0244205 |
| SPAG9 | sperm associated antigen 9 | 0.0242655 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0233409 |
| VEGFA | vascular endothelial growth factor A | 0.0228753 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0226124 |
| LDHA | lactate dehydrogenase A | 0.0223298 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0211748 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0211131 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0208539 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0208196 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.020533 |
| YBX3 | Y box binding protein 3 | 0.020129 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0200714 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0199632 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0198929 |
| ADM | adrenomedullin | 0.0198384 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0196747 |
| DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34 | 0.0195088 |
| SNX9 | sorting nexin 9 | 0.0191818 |
| ATM | ATM serine/threonine kinase | 0.0187423 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0182886 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0180112 |
| GOLT1B | golgi transport 1B | 0.0178047 |
| MSN | moesin | 0.0177788 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0177115 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0176987 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0174914 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0174035 |
| SON | SON DNA binding protein | 0.0171285 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0169453 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0167472 |
| GPR176 | G protein-coupled receptor 176 | 0.0165053 |
| ZNF638 | zinc finger protein 638 | 0.0164585 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0164024 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0164016 |
| FNIP1 | folliculin interacting protein 1 | 0.0163343 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0162798 |
| NBEAL1 | neurobeachin-like 1 | 0.0162524 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0161385 |
| RASA2 | RAS p21 protein activator 2 | 0.0159433 |
| FAM219A | family with sequence similarity 219, member A | 0.0158499 |
| IL6ST | interleukin 6 signal transducer | 0.0157124 |
| GLIS3 | GLIS family zinc finger 3 | 0.015673 |
| YEATS2 | YEATS domain containing 2 | 0.0155754 |
| TMF1 | TATA element modulatory factor 1 | 0.0155221 |
| UBC | ubiquitin C | 0.0153183 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0152515 |
| TNS1 | tensin 1 | 0.0151997 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0151471 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0148626 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0148608 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0147559 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0146924 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.14051 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0941259 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0875258 |
| COL1A1 | collagen, type I, alpha 1 | -0.0811338 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0622023 |
| COL1A2 | collagen, type I, alpha 2 | -0.0488646 |
| OXR1 | oxidation resistance 1 | -0.0482552 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0464858 |
| TMSB10 | thymosin beta 10 | -0.0392925 |
| PTMA | prothymosin, alpha | -0.0377104 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0320635 |
| CAVIN1 | caveolae associated protein 1 | -0.0310679 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0307527 |
| TPM4 | tropomyosin 4 | -0.0298832 |
| ACTG1 | actin gamma 1 | -0.0297446 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0289549 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0288916 |
| RPS6 | ribosomal protein S6 | -0.028692 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0284915 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0284477 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0282969 |
| FTL | ferritin, light polypeptide | -0.02773 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0276157 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0271875 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0264641 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0245585 |
| VCL | vinculin | -0.0243564 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.023562 |
| RPL35A | ribosomal protein L35a | -0.0233736 |
| PDE8A | phosphodiesterase 8A | -0.0232133 |
| PRR16 | proline rich 16 | -0.0224495 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0221846 |
| NCKAP5 | NCK-associated protein 5 | -0.0217099 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0216916 |
| RPL34 | ribosomal protein L34 | -0.0213233 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0211912 |
| RPL37A | ribosomal protein L37a | -0.0208911 |
| CLMP | CXADR-like membrane protein | -0.020323 |
| AHNAK | AHNAK nucleoprotein | -0.0188831 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0188571 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0187749 |
| RAI14 | retinoic acid induced 14 | -0.0186576 |
| RTN4 | reticulon 4 | -0.0186158 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0179623 |
| PRSS23 | protease, serine, 23 | -0.017954 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0177071 |
| PRRX1 | paired related homeobox 1 | -0.017373 |
| MT2A | metallothionein 2A | -0.0173491 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0170478 |
| RAD51B | RAD51 paralog B | -0.0168467 |
| S100A6 | S100 calcium binding protein A6 | -0.0167511 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0167033 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0165676 |
| CALD1 | caldesmon 1 | -0.0164834 |
| IGF2 | insulin-like growth factor 2 | -0.0161311 |
| TPM1 | tropomyosin 1 (alpha) | -0.0160848 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0157163 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0157105 |
| RPS12 | ribosomal protein S12 | -0.0155758 |
| ZFHX3 | zinc finger homeobox 3 | -0.0154108 |
| COL5A3 | collagen, type V, alpha 3 | -0.0153829 |
| RPS25 | ribosomal protein S25 | -0.0153529 |
| RPL23 | ribosomal protein L23 | -0.0152855 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0152373 |
| RPLP1 | ribosomal protein, large, P1 | -0.0151671 |
| COL3A1 | collagen, type III, alpha 1 | -0.0149529 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0147892 |
| NRP1 | neuropilin 1 | -0.014592 |
| RPL9 | ribosomal protein L9 | -0.0145524 |
| RPS24 | ribosomal protein S24 | -0.0144442 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0144276 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0143673 |
| RPS29 | ribosomal protein S29 | -0.0139598 |
| KIAA1549L | KIAA1549-like | -0.0138006 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0136295 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0135935 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0129895 |
| TNS3 | tensin 3 | -0.0129453 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -0.0128567 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.0128283 |
| RPS3 | ribosomal protein S3 | -0.0127407 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0125302 |
| RPL11 | ribosomal protein L11 | -0.0124945 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0123973 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0122337 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.012224 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.012112 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0119804 |
| GNAS | GNAS complex locus | -0.0119319 |
| SP100 | SP100 nuclear antigen | -0.0117796 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0117149 |
| ZNF804A | zinc finger protein 804A | -0.011706 |
| RPL31 | ribosomal protein L31 | -0.011683 |
| HLA-B | major histocompatibility complex, class I, B | -0.0116581 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0115846 |
| PKM | pyruvate kinase, muscle | -0.0115733 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0114992 |
| PDE7B | phosphodiesterase 7B | -0.0114297 |
| RPS8 | ribosomal protein S8 | -0.0113282 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0112784 |
