| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | 0.0697059 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.062979 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0516639 |
| FLNA | filamin A, alpha | 0.0466939 |
| FLNB | filamin B, beta | 0.0369879 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0321673 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0309447 |
| GLIS3 | GLIS family zinc finger 3 | 0.0297828 |
| ARRDC3 | arrestin domain containing 3 | 0.02801 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0249285 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0246376 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0237945 |
| SEPTIN9 | septin 9 | 0.0214231 |
| COL1A2 | collagen, type I, alpha 2 | 0.0207268 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0205453 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0203494 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0199523 |
| RUNX1 | runt-related transcription factor 1 | 0.0198587 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0193295 |
| AUTS2 | autism susceptibility candidate 2 | 0.0192436 |
| ATP13A3 | ATPase type 13A3 | 0.019215 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0188692 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0184769 |
| CD44 | CD44 molecule (Indian blood group) | 0.0184386 |
| C1D | C1D nuclear receptor corepressor | 0.0182473 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0180397 |
| GPC6 | glypican 6 | 0.0173952 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0173142 |
| MSN | moesin | 0.0172831 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0170185 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0165144 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0161206 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0158915 |
| PLEC | plectin | 0.0157624 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0156066 |
| TPM3 | tropomyosin 3 | 0.0154428 |
| L1CAM | L1 cell adhesion molecule | 0.0153882 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0153834 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0147801 |
| PODXL | podocalyxin-like | 0.0145199 |
| RPL3 | ribosomal protein L3 | 0.0144012 |
| RNF145 | ring finger protein 145 | 0.0137476 |
| VEGFC | vascular endothelial growth factor C | 0.0136793 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.0135589 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0135024 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0134021 |
| PCBP2 | poly(rC) binding protein 2 | 0.0133377 |
| FAT1 | FAT atypical cadherin 1 | 0.0131329 |
| SON | SON DNA binding protein | 0.0130586 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0130105 |
| EHBP1 | EH domain binding protein 1 | 0.0127549 |
| THBS2 | thrombospondin 2 | 0.0127477 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.012513 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0122422 |
| FRMD5 | FERM domain containing 5 | 0.0121925 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0121187 |
| MX2 | MX dynamin-like GTPase 2 | 0.0120584 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0119234 |
| CLIC4 | chloride intracellular channel 4 | 0.0118442 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0116566 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0115523 |
| NCKAP1 | NCK-associated protein 1 | 0.0113635 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0112585 |
| TLE4 | transducin-like enhancer of split 4 | 0.0111938 |
| TAPBP | TAP binding protein (tapasin) | 0.0111495 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0111122 |
| COL5A2 | collagen, type V, alpha 2 | 0.0111045 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0108417 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0108407 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0107662 |
| ENAH | enabled homolog (Drosophila) | 0.0107032 |
| ATXN1 | ataxin 1 | 0.0104181 |
| SP3 | Sp3 transcription factor | 0.0103612 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0103546 |
| NOTCH2 | notch 2 | 0.0102577 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0101155 |
| LOXL2 | lysyl oxidase-like 2 | 0.00995687 |
| AFDN | afadin, adherens junction formation factor | 0.00995412 |
| KIFAP3 | kinesin-associated protein 3 | 0.00989721 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.00985112 |
| SVIL | supervillin | 0.00980559 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.00975403 |
| TXNIP | thioredoxin interacting protein | 0.00965884 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.00945526 |
| SBF2 | SET binding factor 2 | 0.00935407 |
| PRRC2A | proline-rich coiled-coil 2A | 0.00921833 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.00913531 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00913423 |
| DENND5A | DENN/MADD domain containing 5A | 0.0090864 |
| MCL1 | myeloid cell leukemia 1 | 0.00906796 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0090381 |
| LAMB1 | laminin, beta 1 | 0.00902459 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.00893702 |
| ANKRD36 | ankyrin repeat domain 36 | 0.00884768 |
| NDRG1 | N-myc downstream regulated 1 | 0.00866974 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00866908 |
| DBN1 | drebrin 1 | 0.0085573 |
| ATL3 | atlastin GTPase 3 | 0.008531 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.00848409 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.00846043 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.342213 |
| VIM | vimentin | -0.296837 |
| TMSB10 | thymosin beta 10 | -0.164438 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.138766 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.117174 |
| CSTB | cystatin B (stefin B) | -0.111158 |
| PTMA | prothymosin, alpha | -0.108727 |
| AHNAK | AHNAK nucleoprotein | -0.102928 |
| CANX | calnexin | -0.10052 |
| S100A6 | S100 calcium binding protein A6 | -0.0920978 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0892672 |
| S100A10 | S100 calcium binding protein A10 | -0.0829057 |
| MT2A | metallothionein 2A | -0.0739694 |
| FN1 | fibronectin 1 | -0.0713442 |
| CDH13 | cadherin 13 | -0.0683766 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0608646 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0562717 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0556318 |
| HLA-B | major histocompatibility complex, class I, B | -0.0526874 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0516967 |
| SQSTM1 | sequestosome 1 | -0.0505174 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0487657 |
| TPM4 | tropomyosin 4 | -0.0471998 |
| LMNA | lamin A/C | -0.046771 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0463224 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.043879 |
| ANXA2 | annexin A2 | -0.0412976 |
| CAVIN1 | caveolae associated protein 1 | -0.0407938 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0400593 |
| RPL35A | ribosomal protein L35a | -0.0393552 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.038917 |
| FTL | ferritin, light polypeptide | -0.0382102 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0369983 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0362306 |
| RPS24 | ribosomal protein S24 | -0.036208 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0361951 |
| RPS8 | ribosomal protein S8 | -0.0357448 |
| RPS6 | ribosomal protein S6 | -0.0355691 |
| CCND1 | cyclin D1 | -0.0355683 |
| RPL37A | ribosomal protein L37a | -0.0352138 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0351405 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0349683 |
| RPLP1 | ribosomal protein, large, P1 | -0.0342382 |
| SEPTIN7 | septin 7 | -0.0334463 |
| TMSB4X | thymosin beta 4, X-linked | -0.0330342 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0325932 |
| RPLP2 | ribosomal protein, large, P2 | -0.0322556 |
| ASPH | aspartate beta-hydroxylase | -0.0319814 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0310457 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0306049 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0301164 |
| B2M | beta-2-microglobulin | -0.0299609 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0298252 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0297682 |
| RAB1A | RAB1A, member RAS oncogene family | -0.02975 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0292449 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0291621 |
| SUCNR1 | succinate receptor 1 | -0.0288789 |
| RND3 | Rho family GTPase 3 | -0.0285321 |
| RPL34 | ribosomal protein L34 | -0.0284053 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0280181 |
| ENO1 | enolase 1, (alpha) | -0.0276468 |
| SEC61G | Sec61 gamma subunit | -0.0271273 |
| LRRC17 | leucine rich repeat containing 17 | -0.0268177 |
| S100A11 | S100 calcium binding protein A11 | -0.0267232 |
| RPL23 | ribosomal protein L23 | -0.0267209 |
| HLA-C | major histocompatibility complex, class I, C | -0.0266584 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0262408 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0261976 |
| MAP1B | microtubule-associated protein 1B | -0.0258199 |
| COL5A1 | collagen, type V, alpha 1 | -0.0257384 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.024862 |
| EGFR | epidermal growth factor receptor | -0.0247173 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0246649 |
| E2F7 | E2F transcription factor 7 | -0.0245261 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0242926 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0242666 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0241967 |
| RPL12 | ribosomal protein L12 | -0.0241541 |
| RPL31 | ribosomal protein L31 | -0.0241342 |
| S100A4 | S100 calcium binding protein A4 | -0.0240966 |
| RPL28 | ribosomal protein L28 | -0.0240246 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0236072 |
| RPS14 | ribosomal protein S14 | -0.0229836 |
| CALR | calreticulin | -0.0229012 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0228663 |
| RPL26 | ribosomal protein L26 | -0.022866 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0227574 |
| GOLGA4 | golgin A4 | -0.0226277 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0225187 |
| RPS27A | ribosomal protein S27a | -0.0225107 |
| INSIG1 | insulin induced gene 1 | -0.0223362 |
| GOLGB1 | golgin B1 | -0.0222186 |
| RPS27 | ribosomal protein S27 | -0.0221717 |
| S100A9 | S100 calcium binding protein A9 | -0.0221066 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0220514 |
| RPL36 | ribosomal protein L36 | -0.021779 |
| RPS19 | ribosomal protein S19 | -0.0216548 |
| RPL19 | ribosomal protein L19 | -0.0216129 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0215466 |
