| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.17555 |
| AREG | amphiregulin | 0.144675 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102959 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0942048 |
| VIM | vimentin | 0.0804227 |
| RPL3 | ribosomal protein L3 | 0.0750551 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.067432 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0552209 |
| ACTG1 | actin gamma 1 | 0.0550349 |
| ANXA1 | annexin A1 | 0.04826 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0460527 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.045283 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0430138 |
| CPOX | coproporphyrinogen oxidase | 0.0423733 |
| CALR | calreticulin | 0.041063 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0409413 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0409185 |
| HMGA2 | high mobility group AT-hook 2 | 0.0384257 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0381493 |
| TXNRD1 | thioredoxin reductase 1 | 0.0369177 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.036867 |
| LDHB | lactate dehydrogenase B | 0.0363241 |
| TPM3 | tropomyosin 3 | 0.0352383 |
| RACK1 | receptor for activated C kinase 1 | 0.0352004 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0317049 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0302666 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0293948 |
| IGF2 | insulin-like growth factor 2 | 0.0272404 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.027041 |
| PCDH9 | protocadherin 9 | 0.0269506 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0259936 |
| RPS12 | ribosomal protein S12 | 0.02588 |
| RPS3 | ribosomal protein S3 | 0.025864 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0255368 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0254676 |
| ANKRD12 | ankyrin repeat domain 12 | 0.025284 |
| RPS4X | ribosomal protein S4, X-linked | 0.0252552 |
| SET | SET nuclear proto-oncogene | 0.0249825 |
| TUBA1B | tubulin, alpha 1b | 0.0248817 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0244213 |
| RHOA | ras homolog family member A | 0.0241427 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0232552 |
| JMJD1C | jumonji domain containing 1C | 0.0219909 |
| FTL | ferritin, light polypeptide | 0.0219126 |
| INTS6 | integrator complex subunit 6 | 0.0218442 |
| PFN1 | profilin 1 | 0.0217928 |
| CLDND1 | claudin domain containing 1 | 0.0217401 |
| TPI1 | triosephosphate isomerase 1 | 0.0216516 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0215647 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0213191 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0209771 |
| SESN2 | sestrin 2 | 0.0205872 |
| PDGFC | platelet derived growth factor C | 0.0199557 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0198255 |
| POTEF | POTE ankyrin domain family, member F | 0.0196985 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0195674 |
| FOSL1 | FOS-like antigen 1 | 0.0193122 |
| GCG | glucagon | 0.0192951 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0191598 |
| HDGF | hepatoma-derived growth factor | 0.0189456 |
| TMEM41B | transmembrane protein 41B | 0.0187789 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0186364 |
| RPS26 | ribosomal protein S26 | 0.0185923 |
| H1-5 | H1.5 linker histone, cluster member | 0.0185189 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0180568 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0179634 |
| CSMD1 | CUB and Sushi multiple domains 1 | 0.0179538 |
| LEKR1 | leucine, glutamate and lysine rich 1 | 0.0179201 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0177406 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0175956 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0175884 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0175474 |
| AHR | aryl hydrocarbon receptor | 0.0174137 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0173118 |
| ARRDC3 | arrestin domain containing 3 | 0.0172101 |
| DSPP | dentin sialophosphoprotein | 0.0172069 |
| PDCD5 | programmed cell death 5 | 0.0169678 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0169348 |
| ENAH | enabled homolog (Drosophila) | 0.0168241 |
| UBC | ubiquitin C | 0.0159803 |
| MKI67 | marker of proliferation Ki-67 | 0.0159498 |
| EGR1 | early growth response 1 | 0.0157762 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0157698 |
| MCL1 | myeloid cell leukemia 1 | 0.0156971 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0154438 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0153844 |
| EPHA5 | EPH receptor A5 | 0.0151951 |
| RPS7 | ribosomal protein S7 | 0.0146825 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0146778 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0146664 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0146119 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0145234 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0144099 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 0.0143573 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0142407 |
| LYPLA1 | lysophospholipase I | 0.014221 |
| RSU1 | Ras suppressor protein 1 | 0.0141345 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0140592 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0139869 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | 0.0137961 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.14236 |
| MMP12 | matrix metallopeptidase 12 | -0.0827187 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.07714 |
| DST | dystonin | -0.0710789 |
| TMSB10 | thymosin beta 10 | -0.0692816 |
| PCDH7 | protocadherin 7 | -0.0669339 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0636276 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0630591 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0577971 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0571427 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0544507 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0530663 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0493896 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0487444 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0484552 |
| PTMA | prothymosin, alpha | -0.0465366 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0459365 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0455315 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0455074 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0451879 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.043306 |
| ADIPOR2 | adiponectin receptor 2 | -0.0428023 |
| SMYD3 | SET and MYND domain containing 3 | -0.0422583 |
| H1-0 | H1.0 linker histone | -0.0419948 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0418116 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.041291 |
| RBM39 | RNA binding motif protein 39 | -0.0395494 |
| FUS | FUS RNA binding protein | -0.0394043 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0392561 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.03901 |
| AHNAK | AHNAK nucleoprotein | -0.038971 |
| POU2F1 | POU class 2 homeobox 1 | -0.0385958 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0382505 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0378976 |
| OGA | O-GlcNAcase | -0.0377732 |
| RPLP1 | ribosomal protein, large, P1 | -0.0373818 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0367947 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0363803 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0359508 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.035693 |
| SPAG9 | sperm associated antigen 9 | -0.0351028 |
| XPO1 | exportin 1 | -0.0349792 |
| ECT2 | epithelial cell transforming 2 | -0.0344647 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0344267 |
| RPL38 | ribosomal protein L38 | -0.0343781 |
| NF1 | neurofibromin 1 | -0.0337233 |
| ZNF292 | zinc finger protein 292 | -0.0335225 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.033118 |
| NEK7 | NIMA-related kinase 7 | -0.0326486 |
| TENM3 | teneurin transmembrane protein 3 | -0.0325479 |
| NEBL | nebulette | -0.0320394 |
| CANX | calnexin | -0.0316544 |
| USP34 | ubiquitin specific peptidase 34 | -0.0311705 |
| RPS24 | ribosomal protein S24 | -0.0311623 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0308033 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0305078 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0303507 |
| CMIP | c-Maf inducing protein | -0.0300644 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0300325 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0299055 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0296943 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0296833 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0296259 |
| YEATS2 | YEATS domain containing 2 | -0.0294105 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0293398 |
| RBM25 | RNA binding motif protein 25 | -0.0293128 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0290632 |
| TPX2 | TPX2, microtubule-associated | -0.0288831 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0286401 |
| ZNF207 | zinc finger protein 207 | -0.0285348 |
| KIF5B | kinesin family member 5B | -0.0285058 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.028402 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0283536 |
| CEP192 | centrosomal protein 192kDa | -0.0282179 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0282153 |
| TNPO1 | transportin 1 | -0.0282145 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0282017 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0280128 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0279097 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0278778 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0276174 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0275138 |
| RAD51B | RAD51 paralog B | -0.027464 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0273568 |
| NUP98 | nucleoporin 98kDa | -0.027319 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0269104 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0268885 |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | -0.0268119 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0267815 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0267023 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0266969 |
| RPS21 | ribosomal protein S21 | -0.0264727 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0262872 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0262846 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.026198 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0261639 |
| RPL35A | ribosomal protein L35a | -0.0259407 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0259381 |
| RPS27A | ribosomal protein S27a | -0.0258883 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0258577 |
