| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.41697 |
| NDRG1 | N-myc downstream regulated 1 | 0.152308 |
| COL6A3 | collagen, type VI, alpha 3 | 0.1435 |
| FN1 | fibronectin 1 | 0.123273 |
| CDH13 | cadherin 13 | 0.101642 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0592644 |
| COL5A1 | collagen, type V, alpha 1 | 0.0588683 |
| EXT1 | exostosin glycosyltransferase 1 | 0.057539 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0402661 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0368835 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.03577 |
| PLEC | plectin | 0.0355392 |
| FBN1 | fibrillin 1 | 0.0354862 |
| GOLGB1 | golgin B1 | 0.035238 |
| VEGFA | vascular endothelial growth factor A | 0.034583 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0328512 |
| GLIS3 | GLIS family zinc finger 3 | 0.0323788 |
| NAV1 | neuron navigator 1 | 0.032303 |
| ASPH | aspartate beta-hydroxylase | 0.0291243 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0279772 |
| EGFR | epidermal growth factor receptor | 0.0257459 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0251955 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0247705 |
| LOXL2 | lysyl oxidase-like 2 | 0.0240473 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0234147 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0233313 |
| ATXN1 | ataxin 1 | 0.0221743 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0215599 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0213194 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.021132 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0210494 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0208211 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0203894 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0198913 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0189336 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0188523 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0186967 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0182606 |
| FLNA | filamin A, alpha | 0.017856 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0173116 |
| CLMP | CXADR-like membrane protein | 0.01727 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.017103 |
| HM13 | histocompatibility (minor) 13 | 0.0165457 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0163726 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0160419 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0159667 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0156711 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0155698 |
| EFNA5 | ephrin-A5 | 0.0152244 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0150392 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0147953 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.014769 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0147401 |
| RPL3 | ribosomal protein L3 | 0.0145419 |
| HMGA2 | high mobility group AT-hook 2 | 0.0143681 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0143014 |
| AHNAK | AHNAK nucleoprotein | 0.0140749 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.0139362 |
| FNIP1 | folliculin interacting protein 1 | 0.0138869 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0133672 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0133124 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0130243 |
| CMIP | c-Maf inducing protein | 0.0128016 |
| STC1 | stanniocalcin 1 | 0.0127935 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0127081 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0126918 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0126833 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0126063 |
| CUX1 | cut-like homeobox 1 | 0.0125561 |
| NEK10 | NIMA-related kinase 10 | 0.0125536 |
| ACTG1 | actin gamma 1 | 0.0125342 |
| HDAC9 | histone deacetylase 9 | 0.012463 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0123904 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0123526 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0123088 |
| RND3 | Rho family GTPase 3 | 0.0122336 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0121561 |
| FOXP1 | forkhead box P1 | 0.012104 |
| SDC2 | syndecan 2 | 0.0120323 |
| FAT1 | FAT atypical cadherin 1 | 0.0118969 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0117662 |
| TBC1D22A | TBC1 domain family, member 22A | 0.011584 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0115369 |
| DST | dystonin | 0.0114995 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0114605 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0113882 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0113333 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0113326 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0112601 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0112461 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0108478 |
| OSMR | oncostatin M receptor | 0.0107217 |
| PGM3 | phosphoglucomutase 3 | 0.0106346 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0105362 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0104532 |
| GOLGA3 | golgin A3 | 0.0104009 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0103663 |
| MYO10 | myosin X | 0.0103128 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0102617 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0102347 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.108615 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.106839 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102352 |
| MT2A | metallothionein 2A | -0.101176 |
| VIM | vimentin | -0.0705931 |
| TMSB10 | thymosin beta 10 | -0.0659344 |
| PTMA | prothymosin, alpha | -0.0563539 |
| CADM1 | cell adhesion molecule 1 | -0.0528143 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0518247 |
| COL1A1 | collagen, type I, alpha 1 | -0.049905 |
| FTL | ferritin, light polypeptide | -0.0481946 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0481709 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0428006 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0405014 |
| MT1X | metallothionein 1X | -0.037599 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0373101 |
| ATP13A3 | ATPase type 13A3 | -0.0358056 |
| IER3 | immediate early response 3 | -0.033009 |
| ZNF292 | zinc finger protein 292 | -0.0329896 |
| RPL35A | ribosomal protein L35a | -0.03263 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0313488 |
| B2M | beta-2-microglobulin | -0.0307347 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.029536 |
| RPS6 | ribosomal protein S6 | -0.0294856 |
| USP3 | ubiquitin specific peptidase 3 | -0.0281854 |
| RPS8 | ribosomal protein S8 | -0.0272471 |
| PFN1 | profilin 1 | -0.0258485 |
| CD44 | CD44 molecule (Indian blood group) | -0.0258368 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0253086 |
| SPAG9 | sperm associated antigen 9 | -0.0246639 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0242138 |
| ANXA2 | annexin A2 | -0.0238945 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0234197 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0229893 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0229614 |
| PKM | pyruvate kinase, muscle | -0.0228425 |
| QKI | QKI, KH domain containing, RNA binding | -0.022762 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.022613 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.022263 |
| SEPTIN7 | septin 7 | -0.0220999 |
| S100A9 | S100 calcium binding protein A9 | -0.0218478 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0213102 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0211732 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0209148 |
| ENO1 | enolase 1, (alpha) | -0.0208922 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0205358 |
| TMSB4X | thymosin beta 4, X-linked | -0.0204994 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0200934 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0200342 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0199945 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0199873 |
| LDHA | lactate dehydrogenase A | -0.0199776 |
| CANX | calnexin | -0.0199157 |
| SQLE | squalene epoxidase | -0.0196285 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0195035 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0194078 |
| RPL12 | ribosomal protein L12 | -0.0190216 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0189212 |
| RPL19 | ribosomal protein L19 | -0.0188025 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0187912 |
| RLF | rearranged L-myc fusion | -0.01871 |
| YBX1 | Y box binding protein 1 | -0.0186322 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0185368 |
| DSTN | destrin (actin depolymerizing factor) | -0.0184786 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0182609 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0182098 |
| RNF145 | ring finger protein 145 | -0.0181852 |
| RPLP1 | ribosomal protein, large, P1 | -0.017919 |
| RPS19 | ribosomal protein S19 | -0.0176706 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0173892 |
| OGA | O-GlcNAcase | -0.0171447 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0171312 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0168194 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0167965 |
| MAP1B | microtubule-associated protein 1B | -0.016627 |
| FAM162A | family with sequence similarity 162, member A | -0.016563 |
| HLA-B | major histocompatibility complex, class I, B | -0.016561 |
| TFG | TRK-fused gene | -0.0163973 |
| PGK1 | phosphoglycerate kinase 1 | -0.0163706 |
| RPLP0 | ribosomal protein, large, P0 | -0.0163541 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0161819 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0159965 |
| RTN4 | reticulon 4 | -0.0159655 |
| RPL8 | ribosomal protein L8 | -0.0158963 |
| SETD5 | SET domain containing 5 | -0.0158933 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.015831 |
| RPL26 | ribosomal protein L26 | -0.0157381 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0155186 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0155039 |
| WASF2 | WAS protein family, member 2 | -0.0154783 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0153955 |
| S100A10 | S100 calcium binding protein A10 | -0.0153745 |
| HMGA1 | high mobility group AT-hook 1 | -0.0153205 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0152155 |
| RPL11 | ribosomal protein L11 | -0.0151758 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0151132 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0150522 |
| POSTN | periostin, osteoblast specific factor | -0.0149853 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0149785 |
| RPL32 | ribosomal protein L32 | -0.0148079 |
