| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.33882 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.119558 |
| C3 | complement component 3 | 0.084582 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0524659 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0505015 |
| RPL3 | ribosomal protein L3 | 0.0447832 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0434842 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0432569 |
| TNS1 | tensin 1 | 0.0404988 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0342259 |
| VEGFA | vascular endothelial growth factor A | 0.0304292 |
| SVIL | supervillin | 0.0250955 |
| GK | glycerol kinase | 0.0239136 |
| PCBP2 | poly(rC) binding protein 2 | 0.0221937 |
| VMP1 | vacuole membrane protein 1 | 0.0218927 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0207461 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0204453 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0200637 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0199497 |
| SMAD3 | SMAD family member 3 | 0.0197573 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0188555 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0186972 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0178545 |
| SEPTIN9 | septin 9 | 0.0172599 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0172047 |
| TPM1 | tropomyosin 1 (alpha) | 0.0169926 |
| KYNU | kynureninase | 0.0168646 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0167761 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0166591 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0165844 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0158003 |
| FAT1 | FAT atypical cadherin 1 | 0.0155542 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0152591 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.015167 |
| STC2 | stanniocalcin 2 | 0.0150198 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0149409 |
| TNS3 | tensin 3 | 0.014816 |
| TJP1 | tight junction protein 1 | 0.0146354 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.0146139 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0145238 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0143604 |
| ZNF638 | zinc finger protein 638 | 0.0143252 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0139994 |
| ATXN1 | ataxin 1 | 0.0139657 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0138354 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0135931 |
| AGRN | agrin | 0.0133245 |
| DIAPH1 | diaphanous-related formin 1 | 0.013295 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0132634 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.013191 |
| MYO1B | myosin IB | 0.0131405 |
| FKTN | fukutin | 0.0131151 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0130476 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0130367 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0129245 |
| FAM13A | family with sequence similarity 13, member A | 0.012912 |
| TPM3 | tropomyosin 3 | 0.0125575 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0125112 |
| NHSL1 | NHS-like 1 | 0.0123891 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0120903 |
| NUP153 | nucleoporin 153kDa | 0.0119405 |
| TGM2 | transglutaminase 2 | 0.0119278 |
| FLNB | filamin B, beta | 0.0118725 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0118401 |
| ZNF207 | zinc finger protein 207 | 0.0117846 |
| PARD3 | par-3 family cell polarity regulator | 0.011733 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0116795 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0116772 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0113428 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0113095 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0112893 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0112728 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0112091 |
| SNX9 | sorting nexin 9 | 0.0111991 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.0111634 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0110626 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0110361 |
| YAP1 | Yes-associated protein 1 | 0.0110168 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0110092 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0109796 |
| MTMR3 | myotubularin related protein 3 | 0.0108844 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0108755 |
| SIK3 | SIK family kinase 3 | 0.0108168 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0108061 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0108014 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0107196 |
| JAG1 | jagged 1 | 0.0106545 |
| USP6NL | USP6 N-terminal like | 0.0106121 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0105783 |
| NUMB | numb homolog (Drosophila) | 0.0105653 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0105606 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0105599 |
| FBXO42 | F-box protein 42 | 0.0104982 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0103531 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0102829 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0102288 |
| PLEC | plectin | 0.0101428 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.010123 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0100779 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0100574 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.178413 |
| GPC3 | glypican 3 | -0.150815 |
| APOB | apolipoprotein B | -0.117246 |
| ENO1 | enolase 1, (alpha) | -0.105697 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0999576 |
| FN1 | fibronectin 1 | -0.099095 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0916265 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0877281 |
| RPS24 | ribosomal protein S24 | -0.0864449 |
| MT2A | metallothionein 2A | -0.0845731 |
| APOA2 | apolipoprotein A-II | -0.0799625 |
| TMSB10 | thymosin beta 10 | -0.0707571 |
| RPL11 | ribosomal protein L11 | -0.0670066 |
| VCL | vinculin | -0.0649448 |
| ASPH | aspartate beta-hydroxylase | -0.0647364 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0643862 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0634134 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0608471 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0602032 |
| RPLP0 | ribosomal protein, large, P0 | -0.0571916 |
| SDC4 | syndecan 4 | -0.0565112 |
| TRIM26 | tripartite motif containing 26 | -0.0549441 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0525015 |
| FTL | ferritin, light polypeptide | -0.050393 |
| CP | ceruloplasmin (ferroxidase) | -0.0495029 |
| DSPP | dentin sialophosphoprotein | -0.0489517 |
| RPS8 | ribosomal protein S8 | -0.0483939 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0483092 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0481859 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0480553 |
| RPL35A | ribosomal protein L35a | -0.047727 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0465993 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0462745 |
| RPL34 | ribosomal protein L34 | -0.0458395 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0448293 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0448075 |
| RPLP1 | ribosomal protein, large, P1 | -0.0442535 |
| RPS21 | ribosomal protein S21 | -0.0430917 |
| RPL26 | ribosomal protein L26 | -0.0420962 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0416261 |
| HMGA1 | high mobility group AT-hook 1 | -0.0411743 |
| H1-0 | H1.0 linker histone | -0.0401603 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0397331 |
| RPS27A | ribosomal protein S27a | -0.0388962 |
| RPL12 | ribosomal protein L12 | -0.0387111 |
| GNAS | GNAS complex locus | -0.0384242 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0376041 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0371665 |
| PTMA | prothymosin, alpha | -0.0366281 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0356233 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0346053 |
| TMEM123 | transmembrane protein 123 | -0.0337153 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0327279 |
| PGK1 | phosphoglycerate kinase 1 | -0.0324638 |
| LDHA | lactate dehydrogenase A | -0.0320839 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0318602 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0313706 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0311557 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0310123 |
| PLIN2 | perilipin 2 | -0.0309707 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0307221 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0304036 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.030266 |
| PTCHD4 | patched domain containing 4 | -0.0301214 |
| RPL9 | ribosomal protein L9 | -0.0294858 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0291523 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0280034 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0278427 |
| EGR1 | early growth response 1 | -0.0278253 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0275357 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0273477 |
| NPR2 | natriuretic peptide receptor 2 | -0.0272638 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0272498 |
| KIF21A | kinesin family member 21A | -0.0272394 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0272057 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0271302 |
| EHBP1 | EH domain binding protein 1 | -0.0269793 |
| PERP | PERP, TP53 apoptosis effector | -0.026868 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0268514 |
| GPC6 | glypican 6 | -0.0267956 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0263315 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0263224 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0259976 |
| RPS5 | ribosomal protein S5 | -0.0258723 |
| A2M | alpha-2-macroglobulin | -0.0258337 |
| TPM4 | tropomyosin 4 | -0.0257984 |
| TMEM263 | transmembrane protein 263 | -0.0257268 |
| APOE | apolipoprotein E | -0.0256197 |
| RPL31 | ribosomal protein L31 | -0.0254183 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0253671 |
| MT1X | metallothionein 1X | -0.0253114 |
| RPL38 | ribosomal protein L38 | -0.0249596 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0245538 |
| RPS12 | ribosomal protein S12 | -0.0244586 |
| RRBP1 | ribosome binding protein 1 | -0.0242468 |
| MIDN | midnolin | -0.0241238 |
| RPLP2 | ribosomal protein, large, P2 | -0.0240842 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0240131 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0240032 |
| PHF3 | PHD finger protein 3 | -0.0238906 |
