AZD1390_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.177442
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.114228
EEF2 eukaryotic translation elongation factor 2 0.108185
LMO7 LIM domain 7 0.104945
MUC6 mucin 6, oligomeric mucus/gel-forming 0.101112
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.100767
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0793397
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0788798
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0645213
MED13 mediator complex subunit 13 0.0610337
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0607044
AFF1 AF4/FMR2 family, member 1 0.0566831
MT2A metallothionein 2A 0.0488585
MACF1 microtubule-actin crosslinking factor 1 0.0480117
RPS6 ribosomal protein S6 0.0473375
LDHA lactate dehydrogenase A 0.0461374
RPL3 ribosomal protein L3 0.0453245
NDRG1 N-myc downstream regulated 1 0.0451635
RPS19 ribosomal protein S19 0.0434879
ABHD2 abhydrolase domain containing 2 0.0430897
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0428309
RPS12 ribosomal protein S12 0.0414458
UBE2H ubiquitin-conjugating enzyme E2H 0.0404363
EIF1 eukaryotic translation initiation factor 1 0.0396136
RPS8 ribosomal protein S8 0.0390778
RPS25 ribosomal protein S25 0.0386998
AKAP13 A kinase (PRKA) anchor protein 13 0.0382195
MYO1E myosin IE 0.0366254
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0340177
PKM pyruvate kinase, muscle 0.0339829
TPM4 tropomyosin 4 0.0324083
RPS13 ribosomal protein S13 0.0319428
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0304543
KRT18 keratin 18, type I 0.0303252
TFF1 trefoil factor 1 0.0299993
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0294924
S100P S100 calcium binding protein P 0.0290459
UNC13B unc-13 homolog B (C. elegans) 0.0285685
RPS14 ribosomal protein S14 0.028266
TGFBR3 transforming growth factor, beta receptor III 0.0278229
SNX9 sorting nexin 9 0.0277861
RPS27 ribosomal protein S27 0.0277704
ANXA1 annexin A1 0.0271364
HSPA8 heat shock 70kDa protein 8 0.0269638
CLIP2 CAP-GLY domain containing linker protein 2 0.0267479
CD44 CD44 molecule (Indian blood group) 0.0266266
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0263961
RPS29 ribosomal protein S29 0.0261372
SRRM2 serine/arginine repetitive matrix 2 0.0258339
PLEC plectin 0.0254851
EZR ezrin 0.025426
P4HB prolyl 4-hydroxylase, beta polypeptide 0.025251
PELI1 pellino E3 ubiquitin protein ligase 1 0.0249356
SLC38A2 solute carrier family 38, member 2 0.0247888
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0246831
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0244265
MUC17 mucin 17, cell surface associated 0.0243636
RPL31 ribosomal protein L31 0.0241315
RACK1 receptor for activated C kinase 1 0.0240454
SLK STE20-like kinase 0.0239493
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0238841
VEGFA vascular endothelial growth factor A 0.0238259
CLCN3 chloride channel, voltage-sensitive 3 0.0234277
SOX9 SRY (sex determining region Y)-box 9 0.0231251
RPS23 ribosomal protein S23 0.0225674
EPS8 epidermal growth factor receptor pathway substrate 8 0.0224207
PTPRR protein tyrosine phosphatase, receptor type, R 0.0221828
USP6NL USP6 N-terminal like 0.0221792
RAB7A RAB7A, member RAS oncogene family 0.0221077
B2M beta-2-microglobulin 0.0220825
VIM vimentin 0.021877
RPS17 ribosomal protein S17 0.0218414
SQSTM1 sequestosome 1 0.0217955
RPL36 ribosomal protein L36 0.0216276
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0216144
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0211377
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0210173
MARCHF3 membrane associated ring-CH-type finger 3 0.0209833
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0206961
CDCP1 CUB domain containing protein 1 0.0206681
RPLP2 ribosomal protein, large, P2 0.0203738
SFTPA2 surfactant protein A2 0.0202825
CMIP c-Maf inducing protein 0.020219
UBC ubiquitin C 0.0202023
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0201721
SAMD4A sterile alpha motif domain containing 4A 0.0200435
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0197716
EMP1 epithelial membrane protein 1 0.0197655
SVIL supervillin 0.0197608
RPS3 ribosomal protein S3 0.0195778
KRT8 keratin 8, type II 0.0195282
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0194615
RPL4 ribosomal protein L4 0.0194435
BRD2 bromodomain containing 2 0.0193221
GDA guanine deaminase 0.0187415
AFF4 AF4/FMR2 family, member 4 0.0185677
RPL7 ribosomal protein L7 0.0185305
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0185006
BAIAP2L1 BAI1-associated protein 2-like 1 0.018289
RPS2 ribosomal protein S2 0.018208

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.228338
VCL vinculin -0.142031
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0924512
PRELID2 PRELI domain containing 2 -0.0837325
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0788294
NALF1 NALCN channel auxiliary factor 1 -0.0774193
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0735839
GPHN gephyrin -0.0692477
FHIT fragile histidine triad -0.0686325
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0646753
PDLIM5 PDZ and LIM domain 5 -0.0632164
PTMA prothymosin, alpha -0.0610408
ALCAM activated leukocyte cell adhesion molecule -0.0582468
AHNAK AHNAK nucleoprotein -0.0579306
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0526042
DENND1A DENN/MADD domain containing 1A -0.0509546
SLC35F3 solute carrier family 35, member F3 -0.0486536
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0478695
CEMIP cell migration inducing protein, hyaluronan binding -0.0478222
EPCAM epithelial cell adhesion molecule -0.0461449
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.043951
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0425132
TAS2R14 taste receptor, type 2, member 14 -0.0420292
RAD51B RAD51 paralog B -0.042023
EXOC4 exocyst complex component 4 -0.039274
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0387306
DLG1 discs, large homolog 1 (Drosophila) -0.0384773
SBF2 SET binding factor 2 -0.0373981
NFIA nuclear factor I/A -0.0370876
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.036575
DIAPH3 diaphanous-related formin 3 -0.0365653
SAMD12 sterile alpha motif domain containing 12 -0.0329853
MLEC malectin -0.0329599
ANKRD10 ankyrin repeat domain 10 -0.03253
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0322712
PIGR polymeric immunoglobulin receptor -0.0321172
GMDS GDP-mannose 4,6-dehydratase -0.0316837
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0314965
TBC1D22A TBC1 domain family, member 22A -0.0312594
LPP LIM domain containing preferred translocation partner in lipoma -0.0312063
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0307386
NSD2 nuclear receptor binding SET domain protein 2 -0.0304636
MECOM MDS1 and EVI1 complex locus -0.0303149
MBD5 methyl-CpG binding domain protein 5 -0.0296182
MAML2 mastermind-like 2 (Drosophila) -0.029363
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0290891
TRIO trio Rho guanine nucleotide exchange factor -0.028935
LAMA4 laminin, alpha 4 -0.0287303
FAM13A family with sequence similarity 13, member A -0.0287006
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0283281
PALLD palladin, cytoskeletal associated protein -0.0281883
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0277485
ETV6 ets variant 6 -0.0277391
ANXA2 annexin A2 -0.0276636
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0273126
SMYD3 SET and MYND domain containing 3 -0.0268157
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0266367
PRSS3 protease, serine, 3 -0.0263553
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0262471
RAB10 RAB10, member RAS oncogene family -0.0262198
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0259637
PKP2 plakophilin 2 -0.0258303
RIN2 Ras and Rab interactor 2 -0.02576
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0256048
ARHGAP26 Rho GTPase activating protein 26 -0.0253896
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0251499
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0251353
RNF43 ring finger protein 43 -0.0251333
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0251304
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.025107
FTH1 ferritin, heavy polypeptide 1 -0.0249727
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0249338
OGA O-GlcNAcase -0.024669
HMGB1 high mobility group box 1 -0.0245196
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0244909
ARHGAP6 Rho GTPase activating protein 6 -0.0243634
MYH9 myosin, heavy chain 9, non-muscle -0.0242871
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.024238
KAZN kazrin, periplakin interacting protein -0.0242212
EHBP1 EH domain binding protein 1 -0.0241436
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0237059
ARHGAP32 Rho GTPase activating protein 32 -0.0236688
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0233326
PPARG peroxisome proliferator-activated receptor gamma -0.0231975
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0231817
RBM39 RNA binding motif protein 39 -0.023069
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0230048
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0229952
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0228781
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0228677
IER3 immediate early response 3 -0.0228413
CCNY cyclin Y -0.0228366
TUFT1 tuftelin 1 -0.0227886
ANLN anillin, actin binding protein -0.0226696
FNBP1L formin binding protein 1-like -0.0226653
NCOR1 nuclear receptor corepressor 1 -0.0226582
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0225892
ANKRD11 ankyrin repeat domain 11 -0.0225544
PCDH9 protocadherin 9 -0.0223413
THSD4 thrombospondin, type I, domain containing 4 -0.0219793