AZD1390_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.093286
TP63 tumor protein p63 0.0716264
HLA-B major histocompatibility complex, class I, B 0.0529334
DST dystonin 0.0475487
VIM vimentin 0.047036
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0456965
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.044306
KTN1 kinectin 1 (kinesin receptor) 0.0395779
RPS12 ribosomal protein S12 0.0394996
RPS4X ribosomal protein S4, X-linked 0.0355596
EFNA5 ephrin-A5 0.0347831
RPS3 ribosomal protein S3 0.0342647
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0336663
RUNX1 runt-related transcription factor 1 0.0329242
RACK1 receptor for activated C kinase 1 0.032206
RPS8 ribosomal protein S8 0.0321156
WARS1 tryptophanyl-tRNA synthetase 1 0.0318902
FTL ferritin, light polypeptide 0.0310476
RNF213 ring finger protein 213 0.0305686
PRELID2 PRELI domain containing 2 0.0295966
B2M beta-2-microglobulin 0.0282438
RPS19 ribosomal protein S19 0.0279012
RPL19 ribosomal protein L19 0.0276037
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0266676
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.026125
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0260978
EPHA4 EPH receptor A4 0.0257844
RPL8 ribosomal protein L8 0.023764
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0235759
TMSB10 thymosin beta 10 0.0234409
RPL26 ribosomal protein L26 0.0233979
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0233269
RPL12 ribosomal protein L12 0.0230272
RPL36 ribosomal protein L36 0.0229339
TNS3 tensin 3 0.0227764
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.022043
ZDHHC14 zinc finger, DHHC-type containing 14 0.0218346
RPL11 ribosomal protein L11 0.0212922
RPL23 ribosomal protein L23 0.0211552
APOLD1 apolipoprotein L domain containing 1 0.0210258
IFI6 interferon, alpha-inducible protein 6 0.0205902
TMSB4X thymosin beta 4, X-linked 0.0202234
LDHA lactate dehydrogenase A 0.0201585
DPYD dihydropyrimidine dehydrogenase 0.0200402
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0194636
RPL27 ribosomal protein L27 0.0182596
RPL37A ribosomal protein L37a 0.0182185
DLG1 discs, large homolog 1 (Drosophila) 0.01781
TPI1 triosephosphate isomerase 1 0.017748
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0175703
SRGN serglycin 0.0174616
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0172572
SRSF11 serine/arginine-rich splicing factor 11 0.0167643
RPLP1 ribosomal protein, large, P1 0.0167396
CADM2 cell adhesion molecule 2 0.0166645
ZFP36L1 ZFP36 ring finger protein-like 1 0.0165634
RPL3 ribosomal protein L3 0.0164501
ENO1 enolase 1, (alpha) 0.0162694
SP100 SP100 nuclear antigen 0.0162425
RPS5 ribosomal protein S5 0.0161102
TPT1 tumor protein, translationally-controlled 1 0.0156147
RPL37 ribosomal protein L37 0.0151591
RPL18 ribosomal protein L18 0.0150092
PTMA prothymosin, alpha 0.0150047
RPL32 ribosomal protein L32 0.0148491
SOD2 superoxide dismutase 2, mitochondrial 0.0147443
ACTG1 actin gamma 1 0.0145815
IFIH1 interferon induced with helicase C domain 1 0.0145713
RPS27 ribosomal protein S27 0.0144423
COL5A2 collagen, type V, alpha 2 0.0143603
JAK1 Janus kinase 1 0.0143538
MBNL2 muscleblind-like splicing regulator 2 0.0141872
DPH6 diphthamine biosynthesis 6 0.0140224
LYST lysosomal trafficking regulator 0.0138424
RPS25 ribosomal protein S25 0.0138327
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0138148
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0136738
DDIT4 DNA-damage-inducible transcript 4 0.0135511
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0134959
RPS10 ribosomal protein S10 0.0134217
RPS24 ribosomal protein S24 0.0134167
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0133708
IFITM1 interferon induced transmembrane protein 1 0.0132185
PRRC2C proline-rich coiled-coil 2C 0.0131804
HDGF hepatoma-derived growth factor 0.0131516
DSCAM Down syndrome cell adhesion molecule 0.0131125
GOLGB1 golgin B1 0.0130429
ECE1 endothelin converting enzyme 1 0.012936
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0128616
RPL30 ribosomal protein L30 0.0128014
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0127475
YY1 YY1 transcription factor 0.012603
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0125462
PABPC1 poly(A) binding protein, cytoplasmic 1 0.012505
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0124961
ANKRD12 ankyrin repeat domain 12 0.0124084
NACA nascent polypeptide-associated complex alpha subunit 0.0122865
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0122847
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0122179
TNIP1 TNFAIP3 interacting protein 1 0.0120058

decreased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 -0.0718515
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0516432
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0474399
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0449329
TXNRD1 thioredoxin reductase 1 -0.0421966
MACF1 microtubule-actin crosslinking factor 1 -0.0398771
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0396839
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0342675
RAI1 retinoic acid induced 1 -0.0317163
USP34 ubiquitin specific peptidase 34 -0.0293367
RAB7A RAB7A, member RAS oncogene family -0.0283923
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0265316
TM4SF1 transmembrane 4 L six family member 1 -0.0242567
EGR1 early growth response 1 -0.0241796
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0230598
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0224715
TRIP12 thyroid hormone receptor interactor 12 -0.0220679
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0219843
RTN4 reticulon 4 -0.0216591
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0210074
NAV2 neuron navigator 2 -0.0206091
CD44 CD44 molecule (Indian blood group) -0.0203381
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0200577
PODXL podocalyxin-like -0.0195601
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0188825
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0188659
FBXO11 F-box protein 11 -0.0184209
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0182146
POTEF POTE ankyrin domain family, member F -0.0177358
MCTP1 multiple C2 domains, transmembrane 1 -0.0176362
GCLM glutamate-cysteine ligase, modifier subunit -0.0171417
UPP1 uridine phosphorylase 1 -0.0169798
APP amyloid beta (A4) precursor protein -0.0168906
GARS1 glycyl-tRNA synthetase 1 -0.0168139
JMJD1C jumonji domain containing 1C -0.0164803
AHNAK AHNAK nucleoprotein -0.0164693
FNDC3B fibronectin type III domain containing 3B -0.0164275
NF1 neurofibromin 1 -0.016343
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0157299
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0156138
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0150926
ADAM17 ADAM metallopeptidase domain 17 -0.0144948
ZEB1 zinc finger E-box binding homeobox 1 -0.014448
RCOR1 REST corepressor 1 -0.0141177
NCEH1 neutral cholesterol ester hydrolase 1 -0.0141085
PYGB phosphorylase, glycogen; brain -0.0140881
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0140729
RAP2B RAP2B, member of RAS oncogene family -0.0138451
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0136759
DPYSL2 dihydropyrimidinase-like 2 -0.013639
EMP1 epithelial membrane protein 1 -0.0136309
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.013522
ZBTB38 zinc finger and BTB domain containing 38 -0.0132741
GSK3B glycogen synthase kinase 3 beta -0.0132088
NUMB numb homolog (Drosophila) -0.013159
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.013095
BZW1 basic leucine zipper and W2 domains 1 -0.0130874
FMNL2 formin-like 2 -0.0129764
SAMD4A sterile alpha motif domain containing 4A -0.0128004
SGK1 serum/glucocorticoid regulated kinase 1 -0.0127902
SLC38A2 solute carrier family 38, member 2 -0.0126915
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0125535
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0124558
TOP1 topoisomerase (DNA) I -0.0124029
GLS2 glutaminase 2 (liver, mitochondrial) -0.0123891
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0122904
MAP4 microtubule-associated protein 4 -0.0122695
GAN gigaxonin -0.0122645
TSC22D2 TSC22 domain family, member 2 -0.012189
ARHGAP29 Rho GTPase activating protein 29 -0.0121494
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0120577
CDCP1 CUB domain containing protein 1 -0.0120485
SBF2 SET binding factor 2 -0.0119475
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0119351
CHD7 chromodomain helicase DNA binding protein 7 -0.0119225
ARL5B ADP-ribosylation factor-like 5B -0.0119136
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0118746
DOCK11 dedicator of cytokinesis 11 -0.0118698
EZR ezrin -0.0118499
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0118029
TMEM41B transmembrane protein 41B -0.0117746
SPRY4 sprouty homolog 4 (Drosophila) -0.0115745
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0113803
ERBIN erbb2 interacting protein -0.011251
ERCC1 excision repair cross-complementation group 1 -0.01105
PUM2 pumilio RNA-binding family member 2 -0.0109646
FLNB filamin B, beta -0.0109614
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0109195
ITGB4 integrin, beta 4 -0.010911
LMAN1 lectin, mannose-binding, 1 -0.0108668
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0108444
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0107383
PRDX1 peroxiredoxin 1 -0.0106945
ZFR zinc finger RNA binding protein -0.0106511
FOSL1 FOS-like antigen 1 -0.0105219
POM121 POM121 transmembrane nucleoporin -0.0105138
CMIP c-Maf inducing protein -0.0101868
BCL2L1 BCL2-like 1 -0.0101646
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0101398
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0100976