| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD1390_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.276184 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.265791 |
| MCL1 | myeloid cell leukemia 1 | 0.141649 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.120839 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.109114 |
| EGR1 | early growth response 1 | 0.106795 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0976578 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0954441 |
| GRAMD1B | GRAM domain containing 1B | 0.0951994 |
| TXNRD1 | thioredoxin reductase 1 | 0.0916416 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0752839 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0744781 |
| STC1 | stanniocalcin 1 | 0.0696558 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0695814 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.066446 |
| LDHA | lactate dehydrogenase A | 0.063883 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0636079 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.06069 |
| LAMC2 | laminin, gamma 2 | 0.0599848 |
| NDRG1 | N-myc downstream regulated 1 | 0.0599297 |
| ANXA2 | annexin A2 | 0.0580715 |
| PKM | pyruvate kinase, muscle | 0.0560066 |
| SPAG9 | sperm associated antigen 9 | 0.0556309 |
| TOP1 | topoisomerase (DNA) I | 0.0536644 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.052706 |
| PTMA | prothymosin, alpha | 0.0522158 |
| ACTG1 | actin gamma 1 | 0.0516802 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0497832 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0469433 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0465073 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0459473 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.045493 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0448564 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0447323 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0441981 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0425147 |
| CES1 | carboxylesterase 1 | 0.0421383 |
| USP34 | ubiquitin specific peptidase 34 | 0.0413581 |
| TES | testin LIM domain protein | 0.0412959 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0407874 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.040539 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0401154 |
| SLTM | SAFB-like, transcription modulator | 0.0396198 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0392194 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0387179 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0379879 |
| HDLBP | high density lipoprotein binding protein | 0.0378167 |
| CPE | carboxypeptidase E | 0.0376025 |
| PGK1 | phosphoglycerate kinase 1 | 0.0372002 |
| CDCP1 | CUB domain containing protein 1 | 0.0371898 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0365578 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0365162 |
| MYO1E | myosin IE | 0.0353281 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0352878 |
| ASPH | aspartate beta-hydroxylase | 0.0351807 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0350102 |
| FAM13A | family with sequence similarity 13, member A | 0.0347036 |
| MKI67 | marker of proliferation Ki-67 | 0.0346665 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0338733 |
| PYGL | phosphorylase, glycogen, liver | 0.0333074 |
| LMO7 | LIM domain 7 | 0.033296 |
| VMP1 | vacuole membrane protein 1 | 0.0332069 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0330991 |
| SIK3 | SIK family kinase 3 | 0.0328094 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0325245 |
| JMJD1C | jumonji domain containing 1C | 0.0317607 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0312959 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0311772 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0310604 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0310029 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0308842 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0305513 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.030476 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0299849 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0299473 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0292492 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0291034 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0289308 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0286998 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0285784 |
| LAMA4 | laminin, alpha 4 | 0.0285237 |
| EZR | ezrin | 0.0282783 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0280347 |
| FLNB | filamin B, beta | 0.0280282 |
| TMSB10 | thymosin beta 10 | 0.0278827 |
| ATP11A | ATPase, class VI, type 11A | 0.027502 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0273095 |
| INTS6 | integrator complex subunit 6 | 0.0271761 |
| BPTF | bromodomain PHD finger transcription factor | 0.0268892 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0268621 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0267963 |
| TAOK1 | TAO kinase 1 | 0.0266191 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0264902 |
| MAGT1 | magnesium transporter 1 | 0.0264685 |
| NF1 | neurofibromin 1 | 0.0264591 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0263425 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0263422 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0260794 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0259368 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0259238 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS3 | ribosomal protein S3 | -0.0472941 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0401369 |
| MT2A | metallothionein 2A | -0.0364187 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0351577 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0349561 |
| EGFR | epidermal growth factor receptor | -0.0322621 |
| RPS12 | ribosomal protein S12 | -0.0315533 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0298624 |
| MYOF | myoferlin | -0.028885 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0277615 |
| RPL11 | ribosomal protein L11 | -0.027546 |
| RACK1 | receptor for activated C kinase 1 | -0.0252824 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0244527 |
| RPL19 | ribosomal protein L19 | -0.0242119 |
| RPL37A | ribosomal protein L37a | -0.0231557 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0229532 |
| RPL31 | ribosomal protein L31 | -0.0212385 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0203324 |
| IFI44L | interferon-induced protein 44-like | -0.0202971 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.020171 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0192131 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0189064 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0187084 |
| RPS29 | ribosomal protein S29 | -0.0185652 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0179852 |
| NTN4 | netrin 4 | -0.0175676 |
| SP100 | SP100 nuclear antigen | -0.0171528 |
| B2M | beta-2-microglobulin | -0.0170973 |
| RPL9 | ribosomal protein L9 | -0.0170949 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0167276 |
| RUNX1 | runt-related transcription factor 1 | -0.0157975 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0155253 |
| FAT1 | FAT atypical cadherin 1 | -0.0154837 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.015456 |
| RPS8 | ribosomal protein S8 | -0.015295 |
| TNS3 | tensin 3 | -0.0151975 |
| SEC61G | Sec61 gamma subunit | -0.0149033 |
| RPS15A | ribosomal protein S15a | -0.0148633 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0144255 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0143542 |
| RPL8 | ribosomal protein L8 | -0.0140974 |
| S100P | S100 calcium binding protein P | -0.0139937 |
| TMEM165 | transmembrane protein 165 | -0.0139725 |
| RSU1 | Ras suppressor protein 1 | -0.0137389 |
| RPS23 | ribosomal protein S23 | -0.0136058 |
| FHL2 | four and a half LIM domains 2 | -0.0135937 |
| IRS2 | insulin receptor substrate 2 | -0.0134476 |
| GPC6 | glypican 6 | -0.0134139 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | -0.0130219 |
| EFNA5 | ephrin-A5 | -0.0129042 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0128133 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0127447 |
| CD163L1 | CD163 molecule-like 1 | -0.0127165 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0126226 |
| RPL13A | ribosomal protein L13a | -0.0125924 |
| RPL26 | ribosomal protein L26 | -0.0124791 |
| RPS4X | ribosomal protein S4, X-linked | -0.0123975 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0120013 |
| RPL30 | ribosomal protein L30 | -0.0119837 |
| RPS27 | ribosomal protein S27 | -0.0119621 |
| RPL27 | ribosomal protein L27 | -0.0119419 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0116739 |
| CP | ceruloplasmin (ferroxidase) | -0.0116166 |
| RPS17 | ribosomal protein S17 | -0.0114672 |
| DSTN | destrin (actin depolymerizing factor) | -0.0113938 |
| RAB10 | RAB10, member RAS oncogene family | -0.0111749 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.011118 |
| TRIM56 | tripartite motif containing 56 | -0.0110678 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0108074 |
| MLPH | melanophilin | -0.0104374 |
| AEBP2 | AE binding protein 2 | -0.0103354 |
| PRDX1 | peroxiredoxin 1 | -0.01033 |
| STC2 | stanniocalcin 2 | -0.010293 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0102038 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0101417 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0101056 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0100787 |
| PMP22 | peripheral myelin protein 22 | -0.010061 |
| RPL12 | ribosomal protein L12 | -0.00991057 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00972968 |
| DHFR | dihydrofolate reductase | -0.0097159 |
| GPC5 | glypican 5 | -0.00970957 |
| RNF213 | ring finger protein 213 | -0.00958406 |
| RPS10 | ribosomal protein S10 | -0.00935649 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0092898 |
| MT1X | metallothionein 1X | -0.00926461 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.00922947 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.00922711 |
| YBX3 | Y box binding protein 3 | -0.0092217 |
| SMAD4 | SMAD family member 4 | -0.00919094 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0091522 |
| PRMT9 | protein arginine methyltransferase 9 | -0.00909115 |
| NEBL | nebulette | -0.00898217 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.00896463 |
| GUK1 | guanylate kinase 1 | -0.00893709 |
| ZNF644 | zinc finger protein 644 | -0.00893542 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00890172 |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | -0.0088162 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00881144 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.00879128 |
