| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.148881 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.132316 |
| CD44 | CD44 molecule (Indian blood group) | 0.126829 |
| GRB10 | growth factor receptor-bound protein 10 | 0.118037 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.117886 |
| NDRG1 | N-myc downstream regulated 1 | 0.117603 |
| FN1 | fibronectin 1 | 0.111716 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0790217 |
| EGR1 | early growth response 1 | 0.0783768 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0754873 |
| PCBP2 | poly(rC) binding protein 2 | 0.0718408 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0655586 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0649208 |
| LOX | lysyl oxidase | 0.0633806 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0606005 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.058515 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0550144 |
| TMSB10 | thymosin beta 10 | 0.0549107 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0534021 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0531642 |
| FLNB | filamin B, beta | 0.0530399 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0517306 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0497616 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.048774 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0484344 |
| ANXA2 | annexin A2 | 0.0472474 |
| PTMA | prothymosin, alpha | 0.0469145 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0449079 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0432012 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0424053 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0395322 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0383277 |
| ENO1 | enolase 1, (alpha) | 0.0383264 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0380285 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0375726 |
| IER3 | immediate early response 3 | 0.0374476 |
| EZR | ezrin | 0.0368415 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0366906 |
| FAM13A | family with sequence similarity 13, member A | 0.0365637 |
| CA12 | carbonic anhydrase XII | 0.0357592 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.035269 |
| FTL | ferritin, light polypeptide | 0.0351387 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0345173 |
| ADM | adrenomedullin | 0.0344275 |
| S100A10 | S100 calcium binding protein A10 | 0.0343003 |
| MAP1B | microtubule-associated protein 1B | 0.0340592 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0335424 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0332655 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0326958 |
| ITGAV | integrin, alpha V | 0.0325658 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0323154 |
| SYAP1 | synapse associated protein 1 | 0.0321609 |
| POTEF | POTE ankyrin domain family, member F | 0.0319133 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0318096 |
| NAV2 | neuron navigator 2 | 0.0318062 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0317803 |
| SMAD3 | SMAD family member 3 | 0.0316928 |
| EMP1 | epithelial membrane protein 1 | 0.031587 |
| OPTN | optineurin | 0.0311644 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0310571 |
| MCL1 | myeloid cell leukemia 1 | 0.0310019 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0306227 |
| PKM | pyruvate kinase, muscle | 0.0303356 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0302208 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0301782 |
| ECE1 | endothelin converting enzyme 1 | 0.0299042 |
| FAM107B | family with sequence similarity 107, member B | 0.0297021 |
| LOXL2 | lysyl oxidase-like 2 | 0.0296763 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0294339 |
| SYT1 | synaptotagmin I | 0.0292083 |
| GOLGA4 | golgin A4 | 0.0291922 |
| PFKP | phosphofructokinase, platelet | 0.0287709 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0286062 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0284884 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0278461 |
| PODXL | podocalyxin-like | 0.0277069 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0275806 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0273436 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0269058 |
| RIOK3 | RIO kinase 3 | 0.0264572 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0262523 |
| RPL35A | ribosomal protein L35a | 0.0259087 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0257953 |
| ATP13A3 | ATPase type 13A3 | 0.0257817 |
| TGM2 | transglutaminase 2 | 0.0255504 |
| PYGL | phosphorylase, glycogen, liver | 0.0255498 |
| MLPH | melanophilin | 0.0254762 |
| CLIC4 | chloride intracellular channel 4 | 0.0253046 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0250142 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0249328 |
| ARF4 | ADP-ribosylation factor 4 | 0.0249103 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0246539 |
| TNNC1 | troponin C type 1 (slow) | 0.0244119 |
| ACTN4 | actinin, alpha 4 | 0.0240002 |
| SPAG9 | sperm associated antigen 9 | 0.0237012 |
| CCDC88A | coiled-coil domain containing 88A | 0.0236469 |
| RAB22A | RAB22A, member RAS oncogene family | 0.023646 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0235667 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.023254 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.023175 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SDK1 | sidekick cell adhesion molecule 1 | -0.150187 |
| NRG1 | neuregulin 1 | -0.14477 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.13213 |
| CDH13 | cadherin 13 | -0.121388 |
| GLCCI1 | glucocorticoid induced 1 | -0.116518 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.108975 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0912833 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0899887 |
| MTSS1 | metastasis suppressor 1 | -0.0822081 |
| VRK2 | vaccinia related kinase 2 | -0.0623205 |
| DNER | delta/notch-like EGF repeat containing | -0.0590439 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0585998 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0563338 |
| FAM20C | family with sequence similarity 20, member C | -0.0563295 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.055385 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0553576 |
| SP100 | SP100 nuclear antigen | -0.0551055 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0537006 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.052389 |
| ZNF804A | zinc finger protein 804A | -0.0489611 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0475518 |
| ANXA10 | annexin A10 | -0.0472093 |
| HMGA2 | high mobility group AT-hook 2 | -0.0466447 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0455558 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0454523 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0434608 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0406529 |
| CDK14 | cyclin-dependent kinase 14 | -0.0405914 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0398788 |
| IFI44L | interferon-induced protein 44-like | -0.0396321 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0394156 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0391016 |
| FRMD4A | FERM domain containing 4A | -0.038667 |
| KYNU | kynureninase | -0.0381051 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0379656 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0357336 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0356043 |
| MECOM | MDS1 and EVI1 complex locus | -0.0354857 |
| GLIS3 | GLIS family zinc finger 3 | -0.0353904 |
| COL12A1 | collagen, type XII, alpha 1 | -0.0349963 |
| NLK | nemo-like kinase | -0.0331668 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0329541 |
| FBN1 | fibrillin 1 | -0.0329441 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0328485 |
| EREG | epiregulin | -0.0328232 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0326236 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0323155 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0321141 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.031266 |
| IFI44 | interferon-induced protein 44 | -0.0304935 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0300904 |
| IL1B | interleukin 1, beta | -0.0300898 |
| GPC6 | glypican 6 | -0.0298835 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0296874 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0290556 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0287738 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0286183 |
| PCNX4 | pecanex 4 | -0.0283292 |
| AVIL | advillin | -0.0282954 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0279898 |
| USP34 | ubiquitin specific peptidase 34 | -0.027732 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0276834 |
| ATG7 | autophagy related 7 | -0.0276407 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0276101 |
| PRRX1 | paired related homeobox 1 | -0.0274515 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0272532 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.027038 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0268706 |
| PRELID2 | PRELI domain containing 2 | -0.0268376 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0266073 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.026239 |
| RPS12 | ribosomal protein S12 | -0.0261847 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0258199 |
| NHSL1 | NHS-like 1 | -0.0254973 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0251386 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0249863 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0249357 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0242914 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0235522 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0234676 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0233514 |
| EFNA5 | ephrin-A5 | -0.0233236 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0233044 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0230209 |
| COMMD10 | COMM domain containing 10 | -0.0225823 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0225612 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0224059 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0221347 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0220026 |
| R3HDM2 | R3H domain containing 2 | -0.0216616 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0215255 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0212807 |
| INTS6 | integrator complex subunit 6 | -0.021266 |
| AEBP2 | AE binding protein 2 | -0.0211928 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0211842 |
| CTSC | cathepsin C | -0.0210469 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0209698 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0208722 |
| KSR1 | kinase suppressor of ras 1 | -0.0207553 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0205795 |
