AZD1390_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.103637
GRAMD1B GRAM domain containing 1B 0.0908881
THSD4 thrombospondin, type I, domain containing 4 0.0889458
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.076138
DOCK4 dedicator of cytokinesis 4 0.0741537
TM4SF1 transmembrane 4 L six family member 1 0.0543206
SVIL supervillin 0.0483505
MCL1 myeloid cell leukemia 1 0.0455282
SAMD4A sterile alpha motif domain containing 4A 0.0450682
MAML3 mastermind-like 3 (Drosophila) 0.0441617
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.042791
SMOC1 SPARC related modular calcium binding 1 0.0422901
CMIP c-Maf inducing protein 0.0410164
DOCK5 dedicator of cytokinesis 5 0.0409243
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0396608
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0376281
GLIS3 GLIS family zinc finger 3 0.0367099
DST dystonin 0.0323341
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0312036
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308031
PTPRM protein tyrosine phosphatase, receptor type, M 0.0304416
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0301622
PM20D1 peptidase M20 domain containing 1 0.0295605
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0292258
ZSWIM6 zinc finger, SWIM-type containing 6 0.0290252
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0282551
MACF1 microtubule-actin crosslinking factor 1 0.0281778
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0277228
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0273196
USP34 ubiquitin specific peptidase 34 0.0268687
EXT1 exostosin glycosyltransferase 1 0.0268108
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0264091
ERRFI1 ERBB receptor feedback inhibitor 1 0.0258458
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0256236
UTRN utrophin 0.0254394
HSPA8 heat shock 70kDa protein 8 0.0249673
ASPH aspartate beta-hydroxylase 0.0247763
FAM107B family with sequence similarity 107, member B 0.0246173
TRIO trio Rho guanine nucleotide exchange factor 0.0246138
KYNU kynureninase 0.024054
EXOC6B exocyst complex component 6B 0.0239034
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0238648
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0231042
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0224449
EEF2 eukaryotic translation elongation factor 2 0.0212237
BICC1 BicC family RNA binding protein 1 0.0211993
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.021038
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0203795
EGFR epidermal growth factor receptor 0.020027
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0197889
RPL4 ribosomal protein L4 0.0195762
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0186587
FNDC3B fibronectin type III domain containing 3B 0.0185944
DOCK1 dedicator of cytokinesis 1 0.0184088
FLNB filamin B, beta 0.0183945
CUX1 cut-like homeobox 1 0.018366
ATP11A ATPase, class VI, type 11A 0.0182637
UBASH3B ubiquitin associated and SH3 domain containing B 0.0180962
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0176664
SLC35F3 solute carrier family 35, member F3 0.0174438
AHNAK AHNAK nucleoprotein 0.0174281
TTC28 tetratricopeptide repeat domain 28 0.0171556
FOXP1 forkhead box P1 0.0170019
SMYD3 SET and MYND domain containing 3 0.0169676
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0169488
SPIDR scaffolding protein involved in DNA repair 0.0168983
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0167611
TRAPPC9 trafficking protein particle complex 9 0.0165036
BTBD9 BTB (POZ) domain containing 9 0.0163412
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0159827
FTO fat mass and obesity associated 0.0159479
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0157693
RPTOR regulatory associated protein of MTOR, complex 1 0.0156753
KDM3B lysine (K)-specific demethylase 3B 0.0154997
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0154344
ATXN1 ataxin 1 0.0153988
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0153252
PCNX1 pecanex 1 0.015278
PARD3B par-3 family cell polarity regulator beta 0.0151782
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0151482
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0150925
SLC38A2 solute carrier family 38, member 2 0.0150786
BMP6 bone morphogenetic protein 6 0.0150496
ZFHX3 zinc finger homeobox 3 0.0149668
BPTF bromodomain PHD finger transcription factor 0.0149408
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0148988
MYO9A myosin IXA 0.0148326
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0147681
PATJ PATJ crumbs cell polarity complex component 0.0146936
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0146654
ZNF638 zinc finger protein 638 0.0146279
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.014611
SFPQ splicing factor proline/glutamine-rich 0.0144545
CNKSR3 CNKSR family member 3 0.0143459
CCDC91 coiled-coil domain containing 91 0.0143217
LRRC23 leucine rich repeat containing 23 0.0142049
FLNA filamin A, alpha 0.01406
CTIF CBP80/20-dependent translation initiation factor 0.013934
NABP1 nucleic acid binding protein 1 0.0139194
NF1 neurofibromin 1 0.013627

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.399049
TMSB10 thymosin beta 10 -0.138417
FTL ferritin, light polypeptide -0.132483
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.130735
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127627
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0921888
FTH1 ferritin, heavy polypeptide 1 -0.082007
VIM vimentin -0.0742379
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0656301
S100A6 S100 calcium binding protein A6 -0.0519887
RPL19 ribosomal protein L19 -0.0486282
EIF1 eukaryotic translation initiation factor 1 -0.0472147
RBM25 RNA binding motif protein 25 -0.0463435
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.045298
PFN1 profilin 1 -0.043433
FGB fibrinogen beta chain -0.0384631
IER3 immediate early response 3 -0.0370915
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.036898
RPL23 ribosomal protein L23 -0.0368925
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.036718
RPLP1 ribosomal protein, large, P1 -0.0350658
KTN1 kinectin 1 (kinesin receptor) -0.03453
HLA-B major histocompatibility complex, class I, B -0.0331478
LOC102724023 ES1 protein homolog, mitochondrial -0.0329429
TXNRD1 thioredoxin reductase 1 -0.0318954
PDIA3 protein disulfide isomerase family A, member 3 -0.0305343
MT1X metallothionein 1X -0.0304493
S100A10 S100 calcium binding protein A10 -0.0300485
B2M beta-2-microglobulin -0.0294169
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290211
C15ORF48 chromosome 15 open reading frame 48 -0.0285392
RPS8 ribosomal protein S8 -0.0284643
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0282358
NAMPT nicotinamide phosphoribosyltransferase -0.0274827
IGF2 insulin-like growth factor 2 -0.0271552
SERF2 small EDRK-rich factor 2 -0.0257967
SRGN serglycin -0.0257635
ATP5F1E ATP synthase F1 subunit epsilon -0.0257165
LDHA lactate dehydrogenase A -0.0255307
BASP1 brain abundant, membrane attached signal protein 1 -0.0252363
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0251482
RPL36 ribosomal protein L36 -0.0251413
STC2 stanniocalcin 2 -0.0249175
HLA-A major histocompatibility complex, class I, A -0.0241795
TPM4 tropomyosin 4 -0.0240894
RPS19 ribosomal protein S19 -0.0236392
RPL35A ribosomal protein L35a -0.0235822
COPA coatomer protein complex, subunit alpha -0.0217825
TPI1 triosephosphate isomerase 1 -0.0215949
NOP58 NOP58 ribonucleoprotein -0.0214954
LMNA lamin A/C -0.0213353
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0210585
S100A11 S100 calcium binding protein A11 -0.0210258
IGFBP4 insulin-like growth factor binding protein 4 -0.0208055
RPL11 ribosomal protein L11 -0.0207219
RPS21 ribosomal protein S21 -0.0200135
AKAP12 A kinase (PRKA) anchor protein 12 -0.0199909
RPS3 ribosomal protein S3 -0.0199725
KPNB1 karyopherin (importin) beta 1 -0.0199383
CALR calreticulin -0.0195124
IL6 interleukin 6 -0.0193307
RPL8 ribosomal protein L8 -0.0191546
CCNL1 cyclin L1 -0.01913
TFG TRK-fused gene -0.0190855
ENO1 enolase 1, (alpha) -0.0188632
SEPTIN7 septin 7 -0.0188502
RPL37 ribosomal protein L37 -0.0188038
UGCG UDP-glucose ceramide glucosyltransferase -0.018758
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0187408
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0184658
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0179661
RPS12 ribosomal protein S12 -0.0179137
USP37 ubiquitin specific peptidase 37 -0.0178411
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0177916
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0176237
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0175165
RPL26 ribosomal protein L26 -0.0174191
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0173349
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0172853
TRA2A transformer 2 alpha homolog (Drosophila) -0.0170079
PDIA6 protein disulfide isomerase family A, member 6 -0.0169907
MYL12B myosin, light chain 12B, regulatory -0.0169075
HDGF hepatoma-derived growth factor -0.0168676
TPT1 tumor protein, translationally-controlled 1 -0.016746
HSPB1 heat shock 27kDa protein 1 -0.0164015
RPS6 ribosomal protein S6 -0.0163493
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0163349
ATP5F1B ATP synthase F1 subunit beta -0.0162718
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.016193
YY1 YY1 transcription factor -0.0160622
ASTN2 astrotactin 2 -0.0160317
RPL36AL ribosomal protein L36a-like -0.0160128
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0159776
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0159309
RPS23 ribosomal protein S23 -0.0158411
PFDN2 prefoldin subunit 2 -0.0158105
RPS5 ribosomal protein S5 -0.0157814
NCEH1 neutral cholesterol ester hydrolase 1 -0.0157135
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0156395
RPL30 ribosomal protein L30 -0.0155698