AZD1390_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.206361
KRT17 keratin 17, type I 0.107457
SAMD4A sterile alpha motif domain containing 4A 0.0998378
BACE2 beta-site APP-cleaving enzyme 2 0.0949116
GRB10 growth factor receptor-bound protein 10 0.0884167
LAMB3 laminin, beta 3 0.086166
SNX9 sorting nexin 9 0.0784076
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0777844
NDRG1 N-myc downstream regulated 1 0.0764481
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0726745
AKAP13 A kinase (PRKA) anchor protein 13 0.0700523
ZNF292 zinc finger protein 292 0.0694987
ATOSA atos homolog A 0.0629562
F3 coagulation factor III (thromboplastin, tissue factor) 0.0605607
LAMC2 laminin, gamma 2 0.0593254
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0583181
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0541927
CXCL8 chemokine (C-X-C motif) ligand 8 0.0515239
MXD1 MAX dimerization protein 1 0.0505234
FNDC3B fibronectin type III domain containing 3B 0.0499588
HOOK2 hook microtubule-tethering protein 2 0.0498425
EZR ezrin 0.0495018
NAMPT nicotinamide phosphoribosyltransferase 0.0491316
HM13 histocompatibility (minor) 13 0.0489981
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0480958
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0469262
STEAP4 STEAP family member 4 0.0466319
ATP11A ATPase, class VI, type 11A 0.0463304
FBXO11 F-box protein 11 0.0456563
ESYT2 extended synaptotagmin-like protein 2 0.0448756
CUX1 cut-like homeobox 1 0.0443483
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.043431
SOD2 superoxide dismutase 2, mitochondrial 0.043041
ERBIN erbb2 interacting protein 0.0430264
TXNRD1 thioredoxin reductase 1 0.0426632
IGF1R insulin-like growth factor 1 receptor 0.0425771
ACTG1 actin gamma 1 0.0425211
EGR1 early growth response 1 0.0412256
CSNK1E casein kinase 1, epsilon 0.040519
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0399847
IFIH1 interferon induced with helicase C domain 1 0.0399388
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0398497
NCOR2 nuclear receptor corepressor 2 0.0396949
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0395582
LPP LIM domain containing preferred translocation partner in lipoma 0.0395553
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.039225
SQSTM1 sequestosome 1 0.0389049
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0384879
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0383661
CEMIP cell migration inducing protein, hyaluronan binding 0.0382768
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0381776
PHF3 PHD finger protein 3 0.0381345
MYO10 myosin X 0.0376537
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.0371322
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.0363496
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0363181
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0357756
TIMP2 TIMP metallopeptidase inhibitor 2 0.0354991
OPTN optineurin 0.0352259
LOC112694756 uncharaterized LOC112694756 0.034383
AKAP12 A kinase (PRKA) anchor protein 12 0.0343294
TNIP1 TNFAIP3 interacting protein 1 0.0342742
LCN2 lipocalin 2 0.0341197
MCTP1 multiple C2 domains, transmembrane 1 0.0338662
RNF145 ring finger protein 145 0.0335858
MCTP2 multiple C2 domains, transmembrane 2 0.033314
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0331636
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0330551
ITSN2 intersectin 2 0.0329139
ARHGAP26 Rho GTPase activating protein 26 0.0327519
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0325175
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0319321
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0317973
KYNU kynureninase 0.0314484
PTEN phosphatase and tensin homolog 0.0313844
STC1 stanniocalcin 1 0.0313236
STAT1 signal transducer and activator of transcription 1, 91kDa 0.030991
UGCG UDP-glucose ceramide glucosyltransferase 0.0303652
SLC38A1 solute carrier family 38, member 1 0.0303515
TIMP3 TIMP metallopeptidase inhibitor 3 0.0299637
APLP2 amyloid beta (A4) precursor-like protein 2 0.0297802
ZMYND8 zinc finger, MYND-type containing 8 0.029542
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0294678
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0291618
ZFC3H1 zinc finger, C3H1-type containing 0.0291471
NCKAP1 NCK-associated protein 1 0.0289529
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0287414
FTH1 ferritin, heavy polypeptide 1 0.0284851
RICTOR RPTOR independent companion of MTOR, complex 2 0.0284438
MX2 MX dynamin-like GTPase 2 0.028385
BRWD1 bromodomain and WD repeat domain containing 1 0.0282274
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0281681
COL6A3 collagen, type VI, alpha 3 0.0279226
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0278407
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0275539
LRRC58 leucine rich repeat containing 58 0.027511
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0273254
PDE8A phosphodiesterase 8A 0.0272768
SP100 SP100 nuclear antigen 0.0272355
PUM2 pumilio RNA-binding family member 2 0.0271247

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144596
TMSB10 thymosin beta 10 -0.11208
PDE4D phosphodiesterase 4D, cAMP-specific -0.0609414
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0595808
MYOF myoferlin -0.0593556
EFNA5 ephrin-A5 -0.0591115
RPL23 ribosomal protein L23 -0.0539067
RPLP0 ribosomal protein, large, P0 -0.0526817
RPS12 ribosomal protein S12 -0.0488669
SMYD3 SET and MYND domain containing 3 -0.0479524
RPL37A ribosomal protein L37a -0.0470332
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0469954
RPS8 ribosomal protein S8 -0.0468098
VIM vimentin -0.0459121
PDE10A phosphodiesterase 10A -0.0448592
RPS3 ribosomal protein S3 -0.0442036
AHNAK AHNAK nucleoprotein -0.0428318
MT2A metallothionein 2A -0.0420305
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0409077
AKAP9 A kinase (PRKA) anchor protein 9 -0.0400364
RPL31 ribosomal protein L31 -0.0400304
ITCH itchy E3 ubiquitin protein ligase -0.0385915
NBEA neurobeachin -0.0378487
DENND1A DENN/MADD domain containing 1A -0.0373095
RPS24 ribosomal protein S24 -0.0366886
PTMA prothymosin, alpha -0.0365755
WARS1 tryptophanyl-tRNA synthetase 1 -0.0356421
ENO1 enolase 1, (alpha) -0.0354131
CCNI cyclin I -0.0353388
AUTS2 autism susceptibility candidate 2 -0.0351519
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0349766
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0342639
NPEPPS aminopeptidase puromycin sensitive -0.034194
TNRC6B trinucleotide repeat containing 6B -0.0339155
NEBL nebulette -0.0337693
ZFAND3 zinc finger, AN1-type domain 3 -0.0334652
SRP54 signal recognition particle 54kDa -0.0332234
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0330949
FLNB filamin B, beta -0.032772
RPL35A ribosomal protein L35a -0.0326326
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0313526
RPL7 ribosomal protein L7 -0.0313268
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0312207
RPL11 ribosomal protein L11 -0.0308849
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.03088
S100A10 S100 calcium binding protein A10 -0.0307115
MTDH metadherin -0.0305201
NBEAL1 neurobeachin-like 1 -0.0296955
SRPK2 SRSF protein kinase 2 -0.0291878
MTSS1 metastasis suppressor 1 -0.0291597
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.02914
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.028687
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0284839
RACK1 receptor for activated C kinase 1 -0.0283045
PRSS23 protease, serine, 23 -0.0281729
PATJ PATJ crumbs cell polarity complex component -0.027912
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0278587
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0277466
SAR1A secretion associated, Ras related GTPase 1A -0.0269871
RPL28 ribosomal protein L28 -0.0267538
ANKRD17 ankyrin repeat domain 17 -0.0267435
RAB10 RAB10, member RAS oncogene family -0.0267415
PCGF5 polycomb group ring finger 5 -0.0265543
BPTF bromodomain PHD finger transcription factor -0.0263389
MARCHF6 membrane associated ring-CH-type finger 6 -0.0262347
PRRC2C proline-rich coiled-coil 2C -0.0262059
PGK1 phosphoglycerate kinase 1 -0.0261249
OSBPL2 oxysterol binding protein-like 2 -0.0259656
CLASP1 cytoplasmic linker associated protein 1 -0.0258649
PTGES2 prostaglandin E synthase 2 -0.0255861
FMNL2 formin-like 2 -0.0254131
RBM39 RNA binding motif protein 39 -0.0246603
FMN1 formin 1 -0.0246047
KIAA0319L KIAA0319-like -0.0245656
TANK TRAF family member-associated NFKB activator -0.024464
TMEM87A transmembrane protein 87A -0.024384
RAB6A RAB6A, member RAS oncogene family -0.0243679
RPL34 ribosomal protein L34 -0.0241862
RPL36A ribosomal protein L36a -0.0241279
PHF21A PHD finger protein 21A -0.0239906
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0237313
DST dystonin -0.0235917
CCDC186 coiled-coil domain containing 186 -0.0231213
WDR45B WD repeat domain 45B -0.0230058
ANXA1 annexin A1 -0.0229766
UBE2H ubiquitin-conjugating enzyme E2H -0.0229582
CELF1 CUGBP, Elav-like family member 1 -0.0228824
RORA RAR-related orphan receptor A -0.0228512
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0226491
SEC24D SEC24 family member D -0.0225333
RPL15 ribosomal protein L15 -0.0225075
SOS1 son of sevenless homolog 1 (Drosophila) -0.0224452
UBC ubiquitin C -0.0224392
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0222794
KDM2A lysine (K)-specific demethylase 2A -0.0220699
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0219171
LAMB1 laminin, beta 1 -0.021873
YAP1 Yes-associated protein 1 -0.0217712
TOP2B topoisomerase (DNA) II beta 180kDa -0.0217153
MAPK6 mitogen-activated protein kinase 6 -0.0216753