AZD1390_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.402805
EEF2 eukaryotic translation elongation factor 2 0.11154
VIM vimentin 0.107916
TMSB10 thymosin beta 10 0.0940419
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0855159
AKAP12 A kinase (PRKA) anchor protein 12 0.0849967
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0655264
RPS4X ribosomal protein S4, X-linked 0.0627251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0571947
EGR1 early growth response 1 0.0550434
TPI1 triosephosphate isomerase 1 0.0528105
FTL ferritin, light polypeptide 0.0526097
LOC102724023 ES1 protein homolog, mitochondrial 0.050399
TXNRD1 thioredoxin reductase 1 0.0480744
ACTG1 actin gamma 1 0.047931
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0452296
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0440212
YBX1 Y box binding protein 1 0.0415335
RPL8 ribosomal protein L8 0.0414092
COPA coatomer protein complex, subunit alpha 0.0392247
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0383157
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0372635
TPM2 tropomyosin 2 (beta) 0.0365951
RAB7A RAB7A, member RAS oncogene family 0.0365518
LDHA lactate dehydrogenase A 0.0354507
CSDE1 cold shock domain containing E1, RNA-binding 0.0342624
GNAS GNAS complex locus 0.0340215
PFN1 profilin 1 0.0328898
RPL35A ribosomal protein L35a 0.031661
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0311966
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.028914
SRRM2 serine/arginine repetitive matrix 2 0.0285903
EIF4A1 eukaryotic translation initiation factor 4A1 0.0285607
SMAD3 SMAD family member 3 0.0285602
PTMA prothymosin, alpha 0.028369
RPS8 ribosomal protein S8 0.02823
RPL23 ribosomal protein L23 0.0278541
IFI6 interferon, alpha-inducible protein 6 0.0269606
RPLP1 ribosomal protein, large, P1 0.0255504
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0249743
LOC112694756 uncharaterized LOC112694756 0.0246423
RPL3 ribosomal protein L3 0.0245538
ZCCHC7 zinc finger, CCHC domain containing 7 0.0243782
VMP1 vacuole membrane protein 1 0.0233493
LDHB lactate dehydrogenase B 0.0231481
TLN1 talin 1 0.0230447
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0229243
RPS19 ribosomal protein S19 0.0222575
GSTP1 glutathione S-transferase pi 1 0.0216821
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0216215
RACK1 receptor for activated C kinase 1 0.0215888
ATP5F1B ATP synthase F1 subunit beta 0.021496
TUBB tubulin, beta class I 0.0213012
HDGF hepatoma-derived growth factor 0.0212579
JUN jun proto-oncogene 0.0212156
UBC ubiquitin C 0.0211788
POTEF POTE ankyrin domain family, member F 0.0210946
RPS3 ribosomal protein S3 0.0207871
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0206189
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0205804
NACA nascent polypeptide-associated complex alpha subunit 0.0202816
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0202302
S100A10 S100 calcium binding protein A10 0.0202003
ZFP36L1 ZFP36 ring finger protein-like 1 0.0198835
AGO2 argonaute RISC catalytic component 2 0.0198537
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.018953
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0187708
BSG basigin (Ok blood group) 0.0186907
MEF2D myocyte enhancer factor 2D 0.0186388
CALR calreticulin 0.018612
KRT18 keratin 18, type I 0.0185183
TAGLN2 transgelin 2 0.0182518
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0181215
IER3 immediate early response 3 0.0181128
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.018076
EEF1G eukaryotic translation elongation factor 1 gamma 0.0177917
UBB ubiquitin B 0.017679
HLA-B major histocompatibility complex, class I, B 0.0175534
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0175454
WASF2 WAS protein family, member 2 0.0175121
NFE2L2 nuclear factor, erythroid 2-like 2 0.0174121
ADIPOR2 adiponectin receptor 2 0.0173842
FLNA filamin A, alpha 0.0173239
KLF6 Kruppel-like factor 6 0.0170584
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.017057
SEC31A SEC31 homolog A (S. cerevisiae) 0.0169098
LMAN1 lectin, mannose-binding, 1 0.0167504
PER1 period circadian clock 1 0.0166863
SRSF3 serine/arginine-rich splicing factor 3 0.0164068
SMIM44 small integral membrane protein 44 0.0162763
RPL12 ribosomal protein L12 0.0162123
TAPBP TAP binding protein (tapasin) 0.0160571
CCNL1 cyclin L1 0.0159599
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0157993
NCOA7 nuclear receptor coactivator 7 0.0156019
MORF4L2 mortality factor 4 like 2 0.0154954
RPL11 ribosomal protein L11 0.0154495
UBAP2L ubiquitin associated protein 2-like 0.0154009
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0154004
ENO1 enolase 1, (alpha) 0.0151356

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.142143
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0602203
NIPBL Nipped-B homolog (Drosophila) -0.0599271
GRAMD1B GRAM domain containing 1B -0.0590718
RTN4 reticulon 4 -0.0557539
TM4SF1 transmembrane 4 L six family member 1 -0.0542042
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0538226
ZFAND3 zinc finger, AN1-type domain 3 -0.0535709
XPO1 exportin 1 -0.045327
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0448824
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0440333
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0430735
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0396084
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0386855
THSD4 thrombospondin, type I, domain containing 4 -0.0384997
MKI67 marker of proliferation Ki-67 -0.0375331
MED13L mediator complex subunit 13-like -0.0368624
EXOC4 exocyst complex component 4 -0.0349838
SMC4 structural maintenance of chromosomes 4 -0.034486
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0337913
KDM2A lysine (K)-specific demethylase 2A -0.032497
BZW1 basic leucine zipper and W2 domains 1 -0.0320242
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0318999
ZBTB20 zinc finger and BTB domain containing 20 -0.0317175
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0309416
RB1CC1 RB1-inducible coiled-coil 1 -0.0308709
PHIP pleckstrin homology domain interacting protein -0.0308322
USP34 ubiquitin specific peptidase 34 -0.030435
ZNF292 zinc finger protein 292 -0.0298028
WDPCP WD repeat containing planar cell polarity effector -0.0294172
MACF1 microtubule-actin crosslinking factor 1 -0.0291725
STK4 serine/threonine kinase 4 -0.0287416
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0286038
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0284731
CENPF centromere protein F, 350/400kDa -0.0283137
RPS2 ribosomal protein S2 -0.027995
ANO6 anoctamin 6 -0.0279036
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0279016
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0277457
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0277416
PPME1 protein phosphatase methylesterase 1 -0.0276051
RAB10 RAB10, member RAS oncogene family -0.0273601
KDM3A lysine (K)-specific demethylase 3A -0.0267781
PUM2 pumilio RNA-binding family member 2 -0.0258635
PTK2 protein tyrosine kinase 2 -0.0257138
KTN1 kinectin 1 (kinesin receptor) -0.0256243
CLTC clathrin, heavy chain (Hc) -0.0254904
TRIO trio Rho guanine nucleotide exchange factor -0.0249224
YBX3 Y box binding protein 3 -0.0247614
BRWD3 bromodomain and WD repeat domain containing 3 -0.0246944
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.024686
MMP12 matrix metallopeptidase 12 -0.0243402
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0243017
CCND2 cyclin D2 -0.0242316
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0240983
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0239276
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0238228
SRPK2 SRSF protein kinase 2 -0.0237851
TAS2R14 taste receptor, type 2, member 14 -0.0235705
ZNF638 zinc finger protein 638 -0.023518
JMJD1C jumonji domain containing 1C -0.0235089
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0233617
SAMD4A sterile alpha motif domain containing 4A -0.0230957
PCNX1 pecanex 1 -0.0230208
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0230128
CEP192 centrosomal protein 192kDa -0.0229976
FNIP1 folliculin interacting protein 1 -0.022439
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0223801
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0223249
BBX bobby sox homolog (Drosophila) -0.0223241
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.022311
OGA O-GlcNAcase -0.0222594
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0221902
RAD51B RAD51 paralog B -0.0221402
CCDC91 coiled-coil domain containing 91 -0.0221348
SPIDR scaffolding protein involved in DNA repair -0.0220735
CDK19 cyclin-dependent kinase 19 -0.0218472
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0217533
CKAP5 cytoskeleton associated protein 5 -0.0217147
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0213994
ARID1B AT rich interactive domain 1B (SWI1-like) -0.021316
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0211514
GPSM2 G-protein signaling modulator 2 -0.0210973
WDR70 WD repeat domain 70 -0.0210358
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0207458
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0207415
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0205714
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0204082
SRPK1 SRSF protein kinase 1 -0.0204078
ANKRD12 ankyrin repeat domain 12 -0.0202457
WNK1 WNK lysine deficient protein kinase 1 -0.0201687
MIPOL1 mirror-image polydactyly 1 -0.0201101
SENP6 SUMO1/sentrin specific peptidase 6 -0.020055
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0199193
DNAH14 dynein, axonemal, heavy chain 14 -0.0198215
MYH9 myosin, heavy chain 9, non-muscle -0.0196772
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0196087
ADAM17 ADAM metallopeptidase domain 17 -0.0195975
CENPE centromere protein E, 312kDa -0.0195619
APP amyloid beta (A4) precursor protein -0.0194596