AZD1390_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the AZD1390_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.226293
ACTG1 actin gamma 1 0.153845
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.130825
PABPC1 poly(A) binding protein, cytoplasmic 1 0.111631
IGFBP3 insulin-like growth factor binding protein 3 0.100298
RACK1 receptor for activated C kinase 1 0.0790672
TMSB10 thymosin beta 10 0.0660665
RPS29 ribosomal protein S29 0.065387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0636066
EEF2 eukaryotic translation elongation factor 2 0.0635061
RPL23 ribosomal protein L23 0.060592
G0S2 G0/G1 switch 2 0.0603502
HMGA1 high mobility group AT-hook 1 0.0599254
RPS3 ribosomal protein S3 0.0594101
RPL8 ribosomal protein L8 0.0572291
PLAU plasminogen activator, urokinase 0.0553583
FTH1 ferritin, heavy polypeptide 1 0.0548103
ISG15 ISG15 ubiquitin-like modifier 0.0545106
UPP1 uridine phosphorylase 1 0.052235
RPL35A ribosomal protein L35a 0.0516024
RPS19 ribosomal protein S19 0.050263
POTEF POTE ankyrin domain family, member F 0.0501299
RPS23 ribosomal protein S23 0.0488786
RPL37 ribosomal protein L37 0.0462593
RPL37A ribosomal protein L37a 0.045682
RPS8 ribosomal protein S8 0.0453366
IFI27 interferon, alpha-inducible protein 27 0.044124
EIF1 eukaryotic translation initiation factor 1 0.0437147
RPS12 ribosomal protein S12 0.0429976
HLA-A major histocompatibility complex, class I, A 0.0420471
RPS27 ribosomal protein S27 0.0409013
SLC38A1 solute carrier family 38, member 1 0.0406186
SOX4 SRY (sex determining region Y)-box 4 0.0403629
KRT7 keratin 7, type II 0.0401793
VIM vimentin 0.0387895
RPL9 ribosomal protein L9 0.0381951
RPLP1 ribosomal protein, large, P1 0.0379501
RPL31 ribosomal protein L31 0.0378209
RPL11 ribosomal protein L11 0.0373605
RPS17 ribosomal protein S17 0.0370067
MT2A metallothionein 2A 0.0365952
IFITM3 interferon induced transmembrane protein 3 0.0361232
RPS6 ribosomal protein S6 0.0348531
RPS14 ribosomal protein S14 0.0345806
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0341375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0341298
B2M beta-2-microglobulin 0.0336464
TPI1 triosephosphate isomerase 1 0.0326302
RPL36 ribosomal protein L36 0.0320342
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0320293
RPLP2 ribosomal protein, large, P2 0.0303952
HLA-B major histocompatibility complex, class I, B 0.0301267
CLDN4 claudin 4 0.0299756
ATP5F1B ATP synthase F1 subunit beta 0.029874
UQCRB ubiquinol-cytochrome c reductase binding protein 0.029349
RPS10 ribosomal protein S10 0.0288353
RPS25 ribosomal protein S25 0.028521
YBX1 Y box binding protein 1 0.0281827
RPL30 ribosomal protein L30 0.0272616
RPS11 ribosomal protein S11 0.0266135
RPL27 ribosomal protein L27 0.0266047
RPL12 ribosomal protein L12 0.0254342
CALR calreticulin 0.0253221
PGBD5 piggyBac transposable element derived 5 0.0246545
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.024554
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.024027
PLEC plectin 0.0239994
RPS4X ribosomal protein S4, X-linked 0.0239726
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0238353
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0238262
LOC112694756 uncharaterized LOC112694756 0.0231104
RPL13A ribosomal protein L13a 0.0226266
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.022554
ZFP36L1 ZFP36 ring finger protein-like 1 0.02233
RPL28 ribosomal protein L28 0.0223193
IFI6 interferon, alpha-inducible protein 6 0.0221754
GOLGB1 golgin B1 0.0220747
RPL19 ribosomal protein L19 0.0220695
RPL15 ribosomal protein L15 0.0217208
TPT1 tumor protein, translationally-controlled 1 0.0214196
IFITM1 interferon induced transmembrane protein 1 0.0210201
ALCAM activated leukocyte cell adhesion molecule 0.0209618
EEF1G eukaryotic translation elongation factor 1 gamma 0.0209413
NACA nascent polypeptide-associated complex alpha subunit 0.0204836
RPLP0 ribosomal protein, large, P0 0.0204281
LOC102724023 ES1 protein homolog, mitochondrial 0.0201668
SRSF3 serine/arginine-rich splicing factor 3 0.0201413
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0197964
HILPDA hypoxia inducible lipid droplet-associated 0.0195774
ATF4 activating transcription factor 4 0.019378
RPL18 ribosomal protein L18 0.0193414
NTN4 netrin 4 0.0192867
SQSTM1 sequestosome 1 0.0189962
EIF5 eukaryotic translation initiation factor 5 0.0189702
CSTB cystatin B (stefin B) 0.0189339
APLP2 amyloid beta (A4) precursor-like protein 2 0.0187133
MDK midkine (neurite growth-promoting factor 2) 0.0186987
GRB10 growth factor receptor-bound protein 10 0.0177651
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0175668
FOSL1 FOS-like antigen 1 0.0175584

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.114598
FNDC3B fibronectin type III domain containing 3B -0.0938581
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0867032
ELL2 elongation factor, RNA polymerase II, 2 -0.0803429
LAMC2 laminin, gamma 2 -0.0800712
NAMPT nicotinamide phosphoribosyltransferase -0.0746879
TRIO trio Rho guanine nucleotide exchange factor -0.0718925
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0718859
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0709985
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0698907
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.062045
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0616635
KDM3A lysine (K)-specific demethylase 3A -0.0557472
PTK2 protein tyrosine kinase 2 -0.0548353
FN1 fibronectin 1 -0.0529856
NDRG1 N-myc downstream regulated 1 -0.0491841
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0490288
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0478104
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0461136
DTNA dystrobrevin, alpha -0.0456342
LPP LIM domain containing preferred translocation partner in lipoma -0.0437104
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0435257
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0431093
RCOR1 REST corepressor 1 -0.0420686
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0406515
GOLGA4 golgin A4 -0.040639
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0405212
PARD3 par-3 family cell polarity regulator -0.0404727
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.040341
MARCHF6 membrane associated ring-CH-type finger 6 -0.0398867
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0378362
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0369571
CLTC clathrin, heavy chain (Hc) -0.0362629
TXNRD1 thioredoxin reductase 1 -0.0361207
EFNA5 ephrin-A5 -0.0359342
PAPOLA poly(A) polymerase alpha -0.0349459
DSG2 desmoglein 2 -0.0348103
CD2AP CD2-associated protein -0.0339487
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0332935
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0328726
RASA2 RAS p21 protein activator 2 -0.0327742
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0325867
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0324456
TMSB4X thymosin beta 4, X-linked -0.0323896
TENT2 terminal nucleotidyltransferase 2 -0.031153
NEK7 NIMA-related kinase 7 -0.0310946
DSCAM Down syndrome cell adhesion molecule -0.030826
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0306546
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0304269
SLMAP sarcolemma associated protein -0.0303787
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.030238
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0299815
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0299718
ITCH itchy E3 ubiquitin protein ligase -0.0299179
SEC31A SEC31 homolog A (S. cerevisiae) -0.0299048
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.029451
ZFAND3 zinc finger, AN1-type domain 3 -0.0291605
OGA O-GlcNAcase -0.0288684
SPAG9 sperm associated antigen 9 -0.028675
ZFAND6 zinc finger, AN1-type domain 6 -0.028651
PTMA prothymosin, alpha -0.0285661
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0282619
RUNX1 runt-related transcription factor 1 -0.0279004
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0273815
KDM6A lysine (K)-specific demethylase 6A -0.0272939
RBM39 RNA binding motif protein 39 -0.027217
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0271265
CTNND1 catenin (cadherin-associated protein), delta 1 -0.026635
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0266213
TFG TRK-fused gene -0.0265581
NUMB numb homolog (Drosophila) -0.0264341
KMT2C lysine (K)-specific methyltransferase 2C -0.0263856
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0263748
STRN3 striatin, calmodulin binding protein 3 -0.0263517
ERBIN erbb2 interacting protein -0.0262066
ZC3H11A zinc finger CCCH-type containing 11A -0.0262036
ZNF292 zinc finger protein 292 -0.0259596
SUCO SUN domain containing ossification factor -0.0258957
CDK17 cyclin-dependent kinase 17 -0.0257707
MYH9 myosin, heavy chain 9, non-muscle -0.0255072
BBX bobby sox homolog (Drosophila) -0.0253998
MYO6 myosin VI -0.0253998
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0252711
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0251061
HMGB2 high mobility group box 2 -0.0249211
ANXA2 annexin A2 -0.0248187
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0247615
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0244177
FAM3C family with sequence similarity 3, member C -0.0244067
FCHO2 FCH domain only 2 -0.0243813
CANX calnexin -0.0243449
RAD21 RAD21 homolog (S. pombe) -0.0242629
TMEM39A transmembrane protein 39A -0.0242117
ESYT2 extended synaptotagmin-like protein 2 -0.0241229
NCKAP1 NCK-associated protein 1 -0.0240552
MED13L mediator complex subunit 13-like -0.0239409
NF1 neurofibromin 1 -0.0237999
MBNL1 muscleblind-like splicing regulator 1 -0.0237908
NAV2 neuron navigator 2 -0.0237069
SBF2 SET binding factor 2 -0.0235646