AZD1390_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.124194
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.102442
TXNRD1 thioredoxin reductase 1 0.0713902
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0685188
FTL ferritin, light polypeptide 0.0602215
VIM vimentin 0.0547983
TMSB10 thymosin beta 10 0.0541889
PTMA prothymosin, alpha 0.0452937
NAMPT nicotinamide phosphoribosyltransferase 0.0425826
RPS6 ribosomal protein S6 0.0419238
EEF2 eukaryotic translation elongation factor 2 0.0417286
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0412208
RPS4X ribosomal protein S4, X-linked 0.0410706
LDHA lactate dehydrogenase A 0.0403492
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0399034
MYOF myoferlin 0.0391618
B2M beta-2-microglobulin 0.0385467
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0385464
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0372055
GDA guanine deaminase 0.0366008
RPS8 ribosomal protein S8 0.0353553
CD109 CD109 molecule 0.0339386
TPT1 tumor protein, translationally-controlled 1 0.0337054
PRRC2C proline-rich coiled-coil 2C 0.0331457
RPLP1 ribosomal protein, large, P1 0.0329082
RPS12 ribosomal protein S12 0.0305034
RPL19 ribosomal protein L19 0.0304459
RPL12 ribosomal protein L12 0.0303717
RACK1 receptor for activated C kinase 1 0.0297362
RPL23 ribosomal protein L23 0.0295181
S100A10 S100 calcium binding protein A10 0.0288573
IGFBP3 insulin-like growth factor binding protein 3 0.0286243
ENO1 enolase 1, (alpha) 0.0285818
RPS19 ribosomal protein S19 0.0285569
ACTG1 actin gamma 1 0.0281975
RPL3 ribosomal protein L3 0.0274421
NAP1L1 nucleosome assembly protein 1-like 1 0.0272823
EIF1 eukaryotic translation initiation factor 1 0.0267937
STC2 stanniocalcin 2 0.0263321
SRGN serglycin 0.0263154
NDRG1 N-myc downstream regulated 1 0.0248657
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0247917
LOC102724023 ES1 protein homolog, mitochondrial 0.0246726
RPLP0 ribosomal protein, large, P0 0.0245893
EIF4A1 eukaryotic translation initiation factor 4A1 0.024351
RPL11 ribosomal protein L11 0.0239966
BASP1 brain abundant, membrane attached signal protein 1 0.0239228
RPL26 ribosomal protein L26 0.0238769
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0235798
RPL35A ribosomal protein L35a 0.0229706
TRIO trio Rho guanine nucleotide exchange factor 0.0228513
TBXT T-box transcription factor T 0.022839
LOC112694756 uncharaterized LOC112694756 0.0226884
RPS3 ribosomal protein S3 0.0226341
SH3KBP1 SH3-domain kinase binding protein 1 0.0222086
UBC ubiquitin C 0.020927
CTSL cathepsin L 0.0205421
RPL31 ribosomal protein L31 0.020513
DGKD diacylglycerol kinase, delta 130kDa 0.0202326
TFPI2 tissue factor pathway inhibitor 2 0.0199499
RPL9 ribosomal protein L9 0.0199343
ATP5F1B ATP synthase F1 subunit beta 0.0196737
TPI1 triosephosphate isomerase 1 0.0195767
PKM pyruvate kinase, muscle 0.0195014
LMNA lamin A/C 0.0194197
NFE2L2 nuclear factor, erythroid 2-like 2 0.0193191
RPL37A ribosomal protein L37a 0.0192653
RPS23 ribosomal protein S23 0.0190746
RPL7A ribosomal protein L7a 0.0189458
S100A6 S100 calcium binding protein A6 0.0188234
NACA nascent polypeptide-associated complex alpha subunit 0.0186341
DDIT4 DNA-damage-inducible transcript 4 0.0185884
SET SET nuclear proto-oncogene 0.0185496
TM4SF1 transmembrane 4 L six family member 1 0.0184538
SAMD4A sterile alpha motif domain containing 4A 0.0179104
RPS24 ribosomal protein S24 0.017862
RPS13 ribosomal protein S13 0.0177956
KTN1 kinectin 1 (kinesin receptor) 0.0176921
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0176494
COL8A1 collagen, type VIII, alpha 1 0.0174481
EZR ezrin 0.0174379
KPNB1 karyopherin (importin) beta 1 0.0173695
RPL35 ribosomal protein L35 0.0173429
PRDX1 peroxiredoxin 1 0.0172164
HLA-A major histocompatibility complex, class I, A 0.0171069
RPL36A ribosomal protein L36a 0.0170885
RPL34 ribosomal protein L34 0.0170865
RPS21 ribosomal protein S21 0.0168627
RPS27 ribosomal protein S27 0.016828
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0168153
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0166762
RPLP2 ribosomal protein, large, P2 0.0166544
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.016579
RPL32 ribosomal protein L32 0.0165242
RPL37 ribosomal protein L37 0.0163285
KRT19 keratin 19, type I 0.0162951
RPS14 ribosomal protein S14 0.0162568
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0162446
PGK1 phosphoglycerate kinase 1 0.0162247
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0161705

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.163855
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.159301
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0708018
CDH13 cadherin 13 -0.0640121
EFNA5 ephrin-A5 -0.0595675
PSD3 pleckstrin and Sec7 domain containing 3 -0.0590183
MAML3 mastermind-like 3 (Drosophila) -0.0538506
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0506795
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0438757
NALF1 NALCN channel auxiliary factor 1 -0.042187
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0409739
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0402201
DST dystonin -0.0390101
PTPRM protein tyrosine phosphatase, receptor type, M -0.0369798
PRKN parkin RBR E3 ubiquitin protein ligase -0.0357093
ADGRD1 adhesion G protein-coupled receptor D1 -0.0344208
DOCK4 dedicator of cytokinesis 4 -0.0333613
PDE10A phosphodiesterase 10A -0.0304219
PCBP3 poly(rC) binding protein 3 -0.0301294
FN1 fibronectin 1 -0.0298133
AUTS2 autism susceptibility candidate 2 -0.0291823
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.028125
SMOC1 SPARC related modular calcium binding 1 -0.0278078
PRELID2 PRELI domain containing 2 -0.0260684
VCL vinculin -0.0249139
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0244968
RAD51B RAD51 paralog B -0.0241458
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0231962
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0229154
FNDC3A fibronectin type III domain containing 3A -0.0218531
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0182707
FNDC3B fibronectin type III domain containing 3B -0.0181653
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0179231
SMYD3 SET and MYND domain containing 3 -0.0179155
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0175729
DENND1A DENN/MADD domain containing 1A -0.0174915
EPHA4 EPH receptor A4 -0.017283
DOCK5 dedicator of cytokinesis 5 -0.0167535
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0166183
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0157407
HDAC4 histone deacetylase 4 -0.0156397
SOD2 superoxide dismutase 2, mitochondrial -0.0150838
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0150335
TTC28 tetratricopeptide repeat domain 28 -0.0149572
PM20D1 peptidase M20 domain containing 1 -0.0147074
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0146469
FNIP1 folliculin interacting protein 1 -0.0145602
SDK1 sidekick cell adhesion molecule 1 -0.0143489
THSD4 thrombospondin, type I, domain containing 4 -0.0140447
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0138421
GPC6 glypican 6 -0.013765
INTS6 integrator complex subunit 6 -0.0129663
SMAD2 SMAD family member 2 -0.0129459
KIAA0825 KIAA0825 -0.0128449
RTN1 reticulon 1 -0.0125154
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0124461
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0124037
P3H2 prolyl 3-hydroxylase 2 -0.0123634
NCKAP5 NCK-associated protein 5 -0.0123452
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0122433
CUX1 cut-like homeobox 1 -0.0121649
CADM2 cell adhesion molecule 2 -0.0121469
TAS2R14 taste receptor, type 2, member 14 -0.0121452
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0120696
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0119726
DNER delta/notch-like EGF repeat containing -0.0118796
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0117694
PCDH15 protocadherin-related 15 -0.0116951
AEBP2 AE binding protein 2 -0.0116803
JMJD1C jumonji domain containing 1C -0.0116456
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0115856
CDK13 cyclin-dependent kinase 13 -0.0114929
SOX6 SRY (sex determining region Y)-box 6 -0.0112714
GLIS3 GLIS family zinc finger 3 -0.0112111
LIMCH1 LIM and calponin homology domains 1 -0.0110961
BCAS3 breast carcinoma amplified sequence 3 -0.0109474
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0108378
NT5C2 5'-nucleotidase, cytosolic II -0.0107482
RIGI RNA sensor RIG-I -0.0104067
MBD5 methyl-CpG binding domain protein 5 -0.010178
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0100305
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.00971432
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.0096222
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.00957726
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00957556
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.00955389
GPRIN3 GPRIN family member 3 -0.0094059
RAB31 RAB31, member RAS oncogene family -0.00923144
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.00921034
DNAH11 dynein, axonemal, heavy chain 11 -0.00913845
CHL1 cell adhesion molecule L1-like -0.00911318
LSAMP limbic system-associated membrane protein -0.00908474
NBEAL1 neurobeachin-like 1 -0.00907605
EXOC4 exocyst complex component 4 -0.00907488
DNAH14 dynein, axonemal, heavy chain 14 -0.00903156
ELL2 elongation factor, RNA polymerase II, 2 -0.00898228
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.00898033
SEC31A SEC31 homolog A (S. cerevisiae) -0.00870997
CANX calnexin -0.00867716
NUMB numb homolog (Drosophila) -0.00840471