| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.0958494 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0930995 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0924233 |
| FTL | ferritin, light polypeptide | 0.0861869 |
| SMYD3 | SET and MYND domain containing 3 | 0.0814565 |
| ASPH | aspartate beta-hydroxylase | 0.0811743 |
| MYO1E | myosin IE | 0.0806506 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0789609 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0787451 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0785868 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.077561 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0768482 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0760226 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0754724 |
| PARD3 | par-3 family cell polarity regulator | 0.0749474 |
| PDE10A | phosphodiesterase 10A | 0.0745954 |
| TMSB10 | thymosin beta 10 | 0.0736728 |
| ACTG1 | actin gamma 1 | 0.0715803 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0714905 |
| ENO1 | enolase 1, (alpha) | 0.0704137 |
| RPS25 | ribosomal protein S25 | 0.0695703 |
| PLEC | plectin | 0.0681325 |
| RPS4X | ribosomal protein S4, X-linked | 0.0664735 |
| FRMD5 | FERM domain containing 5 | 0.0661652 |
| RPL4 | ribosomal protein L4 | 0.0657969 |
| EGFR | epidermal growth factor receptor | 0.0650365 |
| ANXA2 | annexin A2 | 0.0644573 |
| RACK1 | receptor for activated C kinase 1 | 0.0640662 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.064016 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0639639 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0636403 |
| MYOF | myoferlin | 0.0631676 |
| RPS14 | ribosomal protein S14 | 0.0620376 |
| VCL | vinculin | 0.0619375 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0617307 |
| AHNAK | AHNAK nucleoprotein | 0.0604349 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0596452 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0594089 |
| GPC6 | glypican 6 | 0.0592379 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0579851 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0568556 |
| CDK6 | cyclin-dependent kinase 6 | 0.0553993 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0538705 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0527848 |
| TPM4 | tropomyosin 4 | 0.0526914 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0524675 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0524484 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0517723 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0510852 |
| SH3D19 | SH3 domain containing 19 | 0.0502614 |
| NDRG1 | N-myc downstream regulated 1 | 0.050025 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0494855 |
| CD109 | CD109 molecule | 0.0494661 |
| FAT1 | FAT atypical cadherin 1 | 0.0483744 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0478867 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0476381 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.04719 |
| RPL31 | ribosomal protein L31 | 0.0462961 |
| RPLP2 | ribosomal protein, large, P2 | 0.046146 |
| AAK1 | AP2 associated kinase 1 | 0.0455435 |
| NF1 | neurofibromin 1 | 0.0448253 |
| EMP1 | epithelial membrane protein 1 | 0.0443916 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0443318 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0442893 |
| ANO6 | anoctamin 6 | 0.0442488 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0437656 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0436905 |
| VEGFA | vascular endothelial growth factor A | 0.0431216 |
| ERBIN | erbb2 interacting protein | 0.0431179 |
| DOCK4 | dedicator of cytokinesis 4 | 0.042543 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0418403 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0415009 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0414486 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0408473 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0408457 |
| RPS19 | ribosomal protein S19 | 0.0394752 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0383276 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0381681 |
| RPS17 | ribosomal protein S17 | 0.038068 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0372729 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0371119 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0369863 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0367354 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0367318 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0364329 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0357678 |
| RPL26 | ribosomal protein L26 | 0.0354696 |
| USP36 | ubiquitin specific peptidase 36 | 0.0351543 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0350632 |
| DENND1A | DENN/MADD domain containing 1A | 0.0340045 |
| RPL3 | ribosomal protein L3 | 0.0330493 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0322871 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0318322 |
| SETD5 | SET domain containing 5 | 0.0313562 |
| BRD2 | bromodomain containing 2 | 0.0312608 |
| INTS6 | integrator complex subunit 6 | 0.0311034 |
| RPL11 | ribosomal protein L11 | 0.0309412 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0305423 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0297617 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0294211 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.167379 |
| VIM | vimentin | -0.156589 |
| LAMA4 | laminin, alpha 4 | -0.154944 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.150271 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.149075 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.126609 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.111426 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.105498 |
| SPAG9 | sperm associated antigen 9 | -0.0994171 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0977612 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0973097 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.095656 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0926732 |
| RSF1 | remodeling and spacing factor 1 | -0.0914518 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0906087 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0869372 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0865602 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0826236 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0813257 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0800939 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0768103 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0766099 |
| CLTC | clathrin, heavy chain (Hc) | -0.0762992 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.076068 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0733547 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0720112 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0704068 |
| CALU | calumenin | -0.0699793 |
| PTMA | prothymosin, alpha | -0.0688837 |
| PDE8A | phosphodiesterase 8A | -0.0682888 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0677122 |
| MFF | mitochondrial fission factor | -0.063655 |
| RCOR1 | REST corepressor 1 | -0.062413 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0622262 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0595414 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0582267 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0579425 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0577344 |
| MYO10 | myosin X | -0.0570595 |
| SLTM | SAFB-like, transcription modulator | -0.056562 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0549018 |
| SBF2 | SET binding factor 2 | -0.0532282 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0525101 |
| RORA | RAR-related orphan receptor A | -0.051863 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0511997 |
| TPM3 | tropomyosin 3 | -0.0511477 |
| SIK3 | SIK family kinase 3 | -0.0502926 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0479778 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0475333 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0469482 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0463433 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0461465 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0458752 |
| MT2A | metallothionein 2A | -0.0452632 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0451886 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0447078 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0444265 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0439104 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0432269 |
| CDK13 | cyclin-dependent kinase 13 | -0.0429935 |
| GOLGB1 | golgin B1 | -0.042833 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0422124 |
| RPS8 | ribosomal protein S8 | -0.0409089 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0403276 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0397002 |
| CTBP2 | C-terminal binding protein 2 | -0.0386035 |
| RPL15 | ribosomal protein L15 | -0.0382361 |
| TXNRD1 | thioredoxin reductase 1 | -0.037504 |
| VMP1 | vacuole membrane protein 1 | -0.0372122 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0370353 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0369416 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0340192 |
| RTN4 | reticulon 4 | -0.0338783 |
| MAP4 | microtubule-associated protein 4 | -0.032404 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0321674 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.031318 |
| STC1 | stanniocalcin 1 | -0.0308448 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0298783 |
| USP3 | ubiquitin specific peptidase 3 | -0.0298259 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.029582 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0294953 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0285935 |
| CD2AP | CD2-associated protein | -0.0284805 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0279577 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0276138 |
| PKM | pyruvate kinase, muscle | -0.0275647 |
| RBM25 | RNA binding motif protein 25 | -0.0255218 |
| RBM39 | RNA binding motif protein 39 | -0.0254673 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0251139 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.024412 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0243778 |
| PTK2 | protein tyrosine kinase 2 | -0.0236768 |
| CANX | calnexin | -0.0228334 |
| SQSTM1 | sequestosome 1 | -0.0216559 |
| PRELID2 | PRELI domain containing 2 | -0.0210278 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0209797 |
| FAM13A | family with sequence similarity 13, member A | -0.0209075 |
| RPLP0 | ribosomal protein, large, P0 | -0.0207489 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0204628 |
| NAV2 | neuron navigator 2 | -0.020398 |
