| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.102485 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0787722 |
| CADM2 | cell adhesion molecule 2 | 0.0785325 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0594462 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0468559 |
| LRRC4C | leucine rich repeat containing 4C | 0.0425103 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0311728 |
| FOXP2 | forkhead box P2 | 0.0306351 |
| CDH19 | cadherin 19, type 2 | 0.0306163 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0282494 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0270287 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0256825 |
| TENM3 | teneurin transmembrane protein 3 | 0.0249214 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0244411 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0242924 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0234166 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0222591 |
| SKIL | SKI-like proto-oncogene | 0.0206758 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.020105 |
| RPL23 | ribosomal protein L23 | 0.0199931 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0195439 |
| RACK1 | receptor for activated C kinase 1 | 0.0192806 |
| AUTS2 | autism susceptibility candidate 2 | 0.0192454 |
| PCDH9 | protocadherin 9 | 0.0191885 |
| FN1 | fibronectin 1 | 0.019065 |
| PLCB4 | phospholipase C, beta 4 | 0.0189773 |
| PCDH7 | protocadherin 7 | 0.0189569 |
| RIGI | RNA sensor RIG-I | 0.0187371 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0186099 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0185952 |
| INTS6 | integrator complex subunit 6 | 0.0183646 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0182191 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0180217 |
| MEF2C | myocyte enhancer factor 2C | 0.0175927 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.017164 |
| NBEA | neurobeachin | 0.0171624 |
| RASAL2 | RAS protein activator like 2 | 0.0169263 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0169123 |
| DOK6 | docking protein 6 | 0.0167544 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | 0.016752 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0166637 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0163852 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0161959 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0160838 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0157945 |
| MED12L | mediator complex subunit 12-like | 0.0157486 |
| PCDH11Y | protocadherin 11 Y-linked | 0.0157305 |
| TJP1 | tight junction protein 1 | 0.0155893 |
| ANK2 | ankyrin 2, neuronal | 0.0154191 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.0148169 |
| GANAB | glucosidase, alpha; neutral AB | 0.0147533 |
| COL3A1 | collagen, type III, alpha 1 | 0.0146859 |
| OSMR | oncostatin M receptor | 0.014465 |
| SMAD3 | SMAD family member 3 | 0.0143902 |
| HDAC8 | histone deacetylase 8 | 0.0140621 |
| MACROD2 | MACRO domain containing 2 | 0.0140403 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0139997 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | 0.0139099 |
| EPHA3 | EPH receptor A3 | 0.0138843 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | 0.013772 |
| TNRC6C | trinucleotide repeat containing 6C | 0.0137401 |
| TOX | thymocyte selection-associated high mobility group box | 0.0134278 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0134084 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | 0.0132062 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.0131906 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0131562 |
| WWOX | WW domain containing oxidoreductase | 0.013121 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0131159 |
| PBX2 | pre-B-cell leukemia homeobox 2 | 0.0130955 |
| FLNA | filamin A, alpha | 0.0129549 |
| BMP5 | bone morphogenetic protein 5 | 0.0129412 |
| CHRM3 | cholinergic receptor, muscarinic 3 | 0.0129388 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.0128816 |
| GLB1 | galactosidase, beta 1 | 0.0128177 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0127051 |
| LAMA2 | laminin, alpha 2 | 0.0126993 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0126427 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0126199 |
| GLI3 | GLI family zinc finger 3 | 0.0125809 |
| PPL | periplakin | 0.0125317 |
| TRIM2 | tripartite motif containing 2 | 0.0124664 |
| ZNF568 | zinc finger protein 568 | 0.0124383 |
| MB21D2 | Mab-21 domain containing 2 | 0.0123651 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0123168 |
| VEGFA | vascular endothelial growth factor A | 0.0121984 |
| SOX12 | SRY (sex determining region Y)-box 12 | 0.0121776 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0120803 |
| DIPK1A | divergent protein kinase domain 1A | 0.0120759 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0120726 |
| RIC1 | RAB6A GEF complex partner 1 | 0.0120277 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0119422 |
| CUX1 | cut-like homeobox 1 | 0.0119277 |
| PCDH18 | protocadherin 18 | 0.0118791 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0118441 |
| APOE | apolipoprotein E | 0.0116888 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0116258 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0115665 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0114974 |
| EXOC4 | exocyst complex component 4 | 0.0114592 |
| FTL | ferritin, light polypeptide | 0.0114559 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.129308 |
| VIM | vimentin | -0.113109 |
| TSC22D2 | TSC22 domain family, member 2 | -0.109756 |
| PTMA | prothymosin, alpha | -0.105654 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0999326 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0843147 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0834127 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0777845 |
| SRP54 | signal recognition particle 54kDa | -0.0744698 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0738301 |
| TMSB4X | thymosin beta 4, X-linked | -0.0729857 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0719751 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0712605 |
| ZNF292 | zinc finger protein 292 | -0.0706707 |
| PHIP | pleckstrin homology domain interacting protein | -0.0700269 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0682499 |
| PEG10 | paternally expressed 10 | -0.068146 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0639438 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0629598 |
| EMP1 | epithelial membrane protein 1 | -0.0603309 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0582062 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0581403 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0578182 |
| DST | dystonin | -0.0568021 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0563148 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0554806 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0553004 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0537307 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0508467 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0502434 |
| NOP58 | NOP58 ribonucleoprotein | -0.0493646 |
| CLTC | clathrin, heavy chain (Hc) | -0.0484142 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0476629 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0474852 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0473379 |
| RPS6 | ribosomal protein S6 | -0.0472071 |
| SNX6 | sorting nexin 6 | -0.0470735 |
| POTEF | POTE ankyrin domain family, member F | -0.0463438 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0443897 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0441642 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0439159 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0435386 |
| RBM25 | RNA binding motif protein 25 | -0.0426149 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0422788 |
| RAI1 | retinoic acid induced 1 | -0.0422045 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0420796 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0406851 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0399244 |
| MATR3 | matrin 3 | -0.039461 |
| OGA | O-GlcNAcase | -0.0387382 |
| RBM39 | RNA binding motif protein 39 | -0.0385845 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0384102 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.038391 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0382585 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0381441 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0381231 |
| TPX2 | TPX2, microtubule-associated | -0.0380339 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0378984 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.037231 |
| MAP4 | microtubule-associated protein 4 | -0.0370093 |
| GOLGA4 | golgin A4 | -0.0367652 |
| USP3 | ubiquitin specific peptidase 3 | -0.0366362 |
| ANXA2 | annexin A2 | -0.0364682 |
| H1-4 | H1.4 linker histone, cluster member | -0.0361961 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0359747 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0358445 |
| ZFR | zinc finger RNA binding protein | -0.0356811 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0356229 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0355815 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0355347 |
| CDC73 | cell division cycle 73 | -0.0355338 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.0354335 |
| RTN4 | reticulon 4 | -0.0353031 |
| HMGB2 | high mobility group box 2 | -0.0349106 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0348991 |
| APP | amyloid beta (A4) precursor protein | -0.0346994 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0346898 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0340711 |
| TXNRD1 | thioredoxin reductase 1 | -0.0338273 |
| CENPF | centromere protein F, 350/400kDa | -0.0337988 |
| RPS2 | ribosomal protein S2 | -0.0337617 |
| CANX | calnexin | -0.0335442 |
| THBS1 | thrombospondin 1 | -0.0331128 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0327646 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0323563 |
| TMEM123 | transmembrane protein 123 | -0.0320054 |
| TPR | translocated promoter region, nuclear basket protein | -0.0318096 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0317344 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0316837 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0315855 |
| FBL | fibrillarin | -0.031455 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0313486 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0313465 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.031045 |
| TFRC | transferrin receptor | -0.0308197 |
| RLF | rearranged L-myc fusion | -0.0307041 |
| COG5 | component of oligomeric golgi complex 5 | -0.030512 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0304711 |
| CFL2 | cofilin 2 (muscle) | -0.0304701 |
| SEPTIN7 | septin 7 | -0.0304583 |
