AZD1390_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD1390 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD1390_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.113547
EEF2 eukaryotic translation elongation factor 2 0.112517
MYH9 myosin, heavy chain 9, non-muscle 0.0966331
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0911097
SMAD3 SMAD family member 3 0.0793957
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0764008
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0746204
LDHA lactate dehydrogenase A 0.0743732
ARRDC3 arrestin domain containing 3 0.0674925
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0662053
EXT1 exostosin glycosyltransferase 1 0.0662049
FLNA filamin A, alpha 0.0638182
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0602762
THBS1 thrombospondin 1 0.0569289
CD44 CD44 molecule (Indian blood group) 0.0534615
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0525855
UGCG UDP-glucose ceramide glucosyltransferase 0.05071
NAMPT nicotinamide phosphoribosyltransferase 0.0507069
HDAC9 histone deacetylase 9 0.0501641
ZMIZ1 zinc finger, MIZ-type containing 1 0.0475823
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0456202
LOC112694756 uncharaterized LOC112694756 0.0441282
EGR1 early growth response 1 0.0421497
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0420885
MKI67 marker of proliferation Ki-67 0.0420259
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0411456
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0409464
BICC1 BicC family RNA binding protein 1 0.04032
RPL3 ribosomal protein L3 0.0383283
RPS4X ribosomal protein S4, X-linked 0.0383033
TNIP1 TNFAIP3 interacting protein 1 0.0371059
B2M beta-2-microglobulin 0.0366792
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0355248
LOC102724023 ES1 protein homolog, mitochondrial 0.0354145
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0353891
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.034828
TAPBP TAP binding protein (tapasin) 0.0339104
TUBB tubulin, beta class I 0.0330755
SYNJ2 synaptojanin 2 0.032908
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0324982
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0324876
TENT5A terminal nucleotidyltransferase 5A 0.0321818
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0320489
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0318481
ADM adrenomedullin 0.0310633
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0303703
FLNB filamin B, beta 0.0303011
NCOA7 nuclear receptor coactivator 7 0.0294041
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0292836
RUNX1 runt-related transcription factor 1 0.0292021
NONO non-POU domain containing, octamer-binding 0.0290829
VCAN versican 0.0289362
VEGFA vascular endothelial growth factor A 0.0288074
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0286973
CD59 CD59 molecule, complement regulatory protein 0.0286446
FNDC3B fibronectin type III domain containing 3B 0.0284362
COL6A3 collagen, type VI, alpha 3 0.0282202
APLP2 amyloid beta (A4) precursor-like protein 2 0.0277569
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0268728
SHB Src homology 2 domain containing adaptor protein B 0.0267596
ICAM1 intercellular adhesion molecule 1 0.026691
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0265897
MX1 MX dynamin-like GTPase 1 0.0264629
IL1RAP interleukin 1 receptor accessory protein 0.026361
SFTPA2 surfactant protein A2 0.0260007
NAV2 neuron navigator 2 0.0252002
TXNIP thioredoxin interacting protein 0.0243176
ANXA2 annexin A2 0.0237424
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0235695
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0234989
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0232862
MBNL1 muscleblind-like splicing regulator 1 0.023067
ATF3 activating transcription factor 3 0.022997
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0217292
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0217236
LIMA1 LIM domain and actin binding 1 0.0216872
HPCAL1 hippocalcin-like 1 0.02166
IL6 interleukin 6 0.0215021
IRAK2 interleukin-1 receptor-associated kinase 2 0.0213358
CADM1 cell adhesion molecule 1 0.021093
PPARD peroxisome proliferator-activated receptor delta 0.0210156
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0208177
NFE2L2 nuclear factor, erythroid 2-like 2 0.0205292
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0201788
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0201487
STC2 stanniocalcin 2 0.0198402
MSN moesin 0.0198154
UBA6 ubiquitin-like modifier activating enzyme 6 0.0196552
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0193113
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0192996
CREB5 cAMP responsive element binding protein 5 0.0192322
ZBTB38 zinc finger and BTB domain containing 38 0.0190163
RNF213 ring finger protein 213 0.0189364
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0187078
RUNX2 runt-related transcription factor 2 0.0186736
SDC4 syndecan 4 0.0186355
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0184891
PLPP6 phospholipid phosphatase 6 0.0183296
HLA-C major histocompatibility complex, class I, C 0.0181288
FOSL1 FOS-like antigen 1 0.0179053

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.155116
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.125651
TPT1 tumor protein, translationally-controlled 1 -0.0988567
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0925482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0898362
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.087119
IER3 immediate early response 3 -0.0811505
AKAP12 A kinase (PRKA) anchor protein 12 -0.0775171
HMGA2 high mobility group AT-hook 2 -0.0689653
FRMPD4 FERM and PDZ domain containing 4 -0.0650639
PDE10A phosphodiesterase 10A -0.0635388
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.059569
RPL37A ribosomal protein L37a -0.05927
CDH13 cadherin 13 -0.051097
CANX calnexin -0.0508426
RAI14 retinoic acid induced 14 -0.0483733
SDK1 sidekick cell adhesion molecule 1 -0.0468892
RPS24 ribosomal protein S24 -0.0462782
RPS6 ribosomal protein S6 -0.0437679
RPS8 ribosomal protein S8 -0.043678
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0421889
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.04215
PTMA prothymosin, alpha -0.0413089
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0409357
ZMYND8 zinc finger, MYND-type containing 8 -0.0404551
RPL31 ribosomal protein L31 -0.0399917
DIAPH2 diaphanous-related formin 2 -0.039953
FRMD4A FERM domain containing 4A -0.0381066
RPS12 ribosomal protein S12 -0.037834
AFF3 AF4/FMR2 family, member 3 -0.0369072
GLIS3 GLIS family zinc finger 3 -0.0368329
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0367094
MT2A metallothionein 2A -0.0363572
RPLP2 ribosomal protein, large, P2 -0.0362675
TMEM132D transmembrane protein 132D -0.0362337
DST dystonin -0.0352927
WSB1 WD repeat and SOCS box containing 1 -0.0350566
TMSB10 thymosin beta 10 -0.0349875
RPL35A ribosomal protein L35a -0.0349367
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0345601
FTL ferritin, light polypeptide -0.0339094
RPS23 ribosomal protein S23 -0.0322989
RPS29 ribosomal protein S29 -0.0322841
RPL26 ribosomal protein L26 -0.0322009
TRIO trio Rho guanine nucleotide exchange factor -0.0318795
RPL9 ribosomal protein L9 -0.0315412
PLIN2 perilipin 2 -0.0314604
GOLGA4 golgin A4 -0.0314558
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0310741
MMP12 matrix metallopeptidase 12 -0.0309694
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0298888
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.029213
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0287656
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0281408
EGFR epidermal growth factor receptor -0.0281214
SQSTM1 sequestosome 1 -0.0278656
BNC2 basonuclin 2 -0.0275641
RPS3 ribosomal protein S3 -0.0268617
ADAM12 ADAM metallopeptidase domain 12 -0.0268457
RPS16 ribosomal protein S16 -0.0261663
MYOF myoferlin -0.0261143
RPL36A ribosomal protein L36a -0.0259112
GPC6 glypican 6 -0.0256549
INTS6 integrator complex subunit 6 -0.025568
SMYD3 SET and MYND domain containing 3 -0.0247775
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0246668
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0243553
IARS1 isoleucyl-tRNA synthetase 1 -0.0243482
RPL38 ribosomal protein L38 -0.0242032
PHF3 PHD finger protein 3 -0.0239625
CTSD cathepsin D -0.0234412
ZHX2 zinc fingers and homeoboxes 2 -0.0233848
RPS27A ribosomal protein S27a -0.0232903
DTNA dystrobrevin, alpha -0.0231596
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0231324
RPS25 ribosomal protein S25 -0.0230383
DDIT3 DNA-damage-inducible transcript 3 -0.0227441
RPL7A ribosomal protein L7a -0.0226092
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0223839
ATF4 activating transcription factor 4 -0.0222938
SLC38A2 solute carrier family 38, member 2 -0.022053
TENM2 teneurin transmembrane protein 2 -0.0218989
PDE4D phosphodiesterase 4D, cAMP-specific -0.0217239
SPDYA speedy/RINGO cell cycle regulator family member A -0.0216944
RPL11 ribosomal protein L11 -0.0216315
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0215351
RPS14 ribosomal protein S14 -0.0215138
SORBS2 sorbin and SH3 domain containing 2 -0.0215036
FBXO11 F-box protein 11 -0.0213482
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0211965
MACF1 microtubule-actin crosslinking factor 1 -0.0209902
NAV1 neuron navigator 1 -0.0208433
BTBD9 BTB (POZ) domain containing 9 -0.0207276
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0207236
SOX5 SRY (sex determining region Y)-box 5 -0.0206725
RPL23 ribosomal protein L23 -0.0203181
MED13 mediator complex subunit 13 -0.0200906
ENO2 enolase 2 (gamma, neuronal) -0.0200839
RPL36 ribosomal protein L36 -0.0199441
CDK13 cyclin-dependent kinase 13 -0.0199382