| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.0987609 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0484509 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0344821 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0328305 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0286766 |
| ARRDC3 | arrestin domain containing 3 | 0.0267374 |
| SMAD3 | SMAD family member 3 | 0.0208664 |
| MYOF | myoferlin | 0.0204148 |
| FLNA | filamin A, alpha | 0.0194031 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0191701 |
| CALR | calreticulin | 0.0179056 |
| MT2A | metallothionein 2A | 0.0177911 |
| NDRG1 | N-myc downstream regulated 1 | 0.0177544 |
| HDLBP | high density lipoprotein binding protein | 0.0174823 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0169951 |
| AHNAK | AHNAK nucleoprotein | 0.0155952 |
| MAP1B | microtubule-associated protein 1B | 0.0155343 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0154621 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0153955 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0153088 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0150917 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0150886 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0143794 |
| NRXN3 | neurexin 3 | 0.0141913 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0140623 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0138482 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0138039 |
| MKI67 | marker of proliferation Ki-67 | 0.0137907 |
| STC1 | stanniocalcin 1 | 0.0136312 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0135495 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0135167 |
| LDHA | lactate dehydrogenase A | 0.0129163 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0123204 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0121722 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0121703 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0121346 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0117856 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0113182 |
| ENO1 | enolase 1, (alpha) | 0.0112966 |
| MEF2A | myocyte enhancer factor 2A | 0.0111897 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0111071 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0110257 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0108159 |
| TUBB | tubulin, beta class I | 0.0106853 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0104759 |
| FRMD6 | FERM domain containing 6 | 0.0104704 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0104644 |
| CLTC | clathrin, heavy chain (Hc) | 0.0103729 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0103167 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0103031 |
| NEK7 | NIMA-related kinase 7 | 0.0102793 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0100694 |
| PLEC | plectin | 0.0100657 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0100397 |
| ATP13A3 | ATPase type 13A3 | 0.0100395 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.00994809 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0098667 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.00985528 |
| HPCAL1 | hippocalcin-like 1 | 0.00977037 |
| RPL3 | ribosomal protein L3 | 0.00964273 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.00954498 |
| CD44 | CD44 molecule (Indian blood group) | 0.00923262 |
| TPR | translocated promoter region, nuclear basket protein | 0.00915744 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.00905665 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.00900775 |
| ACTN1 | actinin, alpha 1 | 0.00898136 |
| THBS1 | thrombospondin 1 | 0.00895632 |
| AOPEP | aminopeptidase O (putative) | 0.00895008 |
| NIBAN2 | niban apoptosis regulator 2 | 0.00893835 |
| CALU | calumenin | 0.00893645 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.00880167 |
| DST | dystonin | 0.00870874 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00870055 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0086821 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.00861608 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.00858648 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.00851131 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.00838956 |
| SETD5 | SET domain containing 5 | 0.00837478 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.00811014 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.00810747 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00800023 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.00793117 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00789256 |
| ANXA5 | annexin A5 | 0.00783596 |
| MYO9B | myosin IXB | 0.00782875 |
| EMP1 | epithelial membrane protein 1 | 0.00770668 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.00766101 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00764631 |
| YME1L1 | YME1-like 1 ATPase | 0.00763725 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.00760221 |
| FAM133B | family with sequence similarity 133, member B | 0.00755457 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.00754561 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00752834 |
| EREG | epiregulin | 0.00745238 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.0074456 |
| GOLGB1 | golgin B1 | 0.00738433 |
| LAMB1 | laminin, beta 1 | 0.00732842 |
| LOXL2 | lysyl oxidase-like 2 | 0.00729858 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.00726944 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0454801 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0400557 |
| VIM | vimentin | -0.0328622 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0286311 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0229826 |
| IL6 | interleukin 6 | -0.0208098 |
| POTEF | POTE ankyrin domain family, member F | -0.0203963 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0203293 |
| TNS3 | tensin 3 | -0.0195345 |
| CDH13 | cadherin 13 | -0.0189551 |
| CADM1 | cell adhesion molecule 1 | -0.0188042 |
| MED13L | mediator complex subunit 13-like | -0.01796 |
| RPL35A | ribosomal protein L35a | -0.0172931 |
| KAZN | kazrin, periplakin interacting protein | -0.0169127 |
| LOX | lysyl oxidase | -0.0165108 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0155576 |
| HLA-B | major histocompatibility complex, class I, B | -0.0153423 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0144351 |
| HLA-A | major histocompatibility complex, class I, A | -0.0143775 |
| EGFR | epidermal growth factor receptor | -0.0143724 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0141607 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0135886 |
| VCL | vinculin | -0.0130363 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0129994 |
| CANX | calnexin | -0.0126983 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0124184 |
| PTMA | prothymosin, alpha | -0.0124128 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0122036 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0121697 |
| DTNA | dystrobrevin, alpha | -0.0119792 |
| PKM | pyruvate kinase, muscle | -0.0119168 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0118292 |
| RPLP1 | ribosomal protein, large, P1 | -0.0117912 |
| PRSS23 | protease, serine, 23 | -0.0117267 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0115618 |
| FBXO11 | F-box protein 11 | -0.011526 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0113846 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0109262 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0109213 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0109152 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0107519 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0107255 |
| RPL23 | ribosomal protein L23 | -0.0105821 |
| SEPTIN7 | septin 7 | -0.0104953 |
| S100A6 | S100 calcium binding protein A6 | -0.0104445 |
| RPS6 | ribosomal protein S6 | -0.0102548 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0102139 |
| QKI | QKI, KH domain containing, RNA binding | -0.0100061 |
| MTDH | metadherin | -0.00985876 |
| RPL38 | ribosomal protein L38 | -0.00980836 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00975734 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.00974805 |
| RPL9 | ribosomal protein L9 | -0.00970509 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00962732 |
| AUTS2 | autism susceptibility candidate 2 | -0.0095431 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00930227 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0091688 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.00909004 |
| S100A9 | S100 calcium binding protein A9 | -0.00904567 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00893862 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.00882094 |
| INTS6 | integrator complex subunit 6 | -0.00868069 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00867706 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00866245 |
| COL5A2 | collagen, type V, alpha 2 | -0.0086265 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00852192 |
| RPL31 | ribosomal protein L31 | -0.00850367 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.00833109 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.00828574 |
| LSAMP | limbic system-associated membrane protein | -0.00827558 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00816161 |
| AFF3 | AF4/FMR2 family, member 3 | -0.00813959 |
| RPS25 | ribosomal protein S25 | -0.00806024 |
| RND3 | Rho family GTPase 3 | -0.00801972 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00800334 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.00800278 |
| RPL34 | ribosomal protein L34 | -0.00796987 |
| PFN1 | profilin 1 | -0.00795257 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.00789387 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.00785409 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.00784684 |
| CLEC1B | C-type lectin domain family 1, member B | -0.00776951 |
| RPS27A | ribosomal protein S27a | -0.0077587 |
| RASAL2 | RAS protein activator like 2 | -0.00771086 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.00768246 |
| MMP12 | matrix metallopeptidase 12 | -0.00759692 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.00759291 |
| VEGFA | vascular endothelial growth factor A | -0.00743534 |
| PCNX4 | pecanex 4 | -0.00740675 |
| MYADM | myeloid-associated differentiation marker | -0.00740031 |
| RPS12 | ribosomal protein S12 | -0.00735935 |
| FRMD4A | FERM domain containing 4A | -0.00731424 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00729845 |
| SRPK2 | SRSF protein kinase 2 | -0.00728494 |
| TSC22D2 | TSC22 domain family, member 2 | -0.00725379 |
| NKTR | natural killer cell triggering receptor | -0.00722301 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.00722277 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00718202 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.00716159 |
| RPS14 | ribosomal protein S14 | -0.00713541 |
