| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0791 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0397082 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0389787 |
| PKM | pyruvate kinase, muscle | 0.0380064 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0304573 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0290047 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0283563 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0279541 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0278961 |
| RUNX1 | runt-related transcription factor 1 | 0.0277237 |
| SQSTM1 | sequestosome 1 | 0.0277178 |
| FLNA | filamin A, alpha | 0.0274025 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0269644 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.026542 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0256634 |
| PRKCA | protein kinase C, alpha | 0.0251698 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0246503 |
| TRAM2 | translocation associated membrane protein 2 | 0.0240274 |
| IGF2 | insulin-like growth factor 2 | 0.0239763 |
| PODXL | podocalyxin-like | 0.0235036 |
| B2M | beta-2-microglobulin | 0.0232038 |
| ZNF638 | zinc finger protein 638 | 0.0225689 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0224043 |
| RPL3 | ribosomal protein L3 | 0.0222544 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0219392 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0217847 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0214125 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0213917 |
| TLE4 | transducin-like enhancer of split 4 | 0.0213088 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0211611 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0211375 |
| DENND5B | DENN/MADD domain containing 5B | 0.0211318 |
| XPC | xeroderma pigmentosum, complementation group C | 0.021106 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0210557 |
| E2F7 | E2F transcription factor 7 | 0.021033 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0209409 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0204271 |
| KLHL29 | kelch-like family member 29 | 0.0204101 |
| SSRP1 | structure specific recognition protein 1 | 0.0202108 |
| ALS2 | amyotrophic lateral sclerosis 2 (juvenile) | 0.0201889 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0197926 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0197732 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | 0.0196645 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0196234 |
| ABHD3 | abhydrolase domain containing 3 | 0.0196173 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0195792 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.0195034 |
| EGFR | epidermal growth factor receptor | 0.0193876 |
| TRAPPC8 | trafficking protein particle complex 8 | 0.0193258 |
| POTEF | POTE ankyrin domain family, member F | 0.0191761 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0191007 |
| TAGLN2 | transgelin 2 | 0.0190941 |
| VEGFA | vascular endothelial growth factor A | 0.0185335 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0185051 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.0183182 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0180696 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0180493 |
| DGKH | diacylglycerol kinase, eta | 0.0180157 |
| MFSD14B | major facilitator superfamily domain containing 14B | 0.0178249 |
| BRD2 | bromodomain containing 2 | 0.0177703 |
| GAN | gigaxonin | 0.017737 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0176289 |
| CCND1 | cyclin D1 | 0.0175798 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | 0.0175606 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0174341 |
| FRMD8 | FERM domain containing 8 | 0.0172522 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0172308 |
| TPD52L2 | tumor protein D52-like 2 | 0.0171925 |
| RPL13A | ribosomal protein L13a | 0.0170115 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0169664 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0169253 |
| ARHGAP31 | Rho GTPase activating protein 31 | 0.0169032 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0167843 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0166383 |
| CAB39 | calcium binding protein 39 | 0.0164153 |
| JAK1 | Janus kinase 1 | 0.0164081 |
| HMGA2 | high mobility group AT-hook 2 | 0.0163164 |
| ULK1 | unc-51 like autophagy activating kinase 1 | 0.0163014 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0161887 |
| INTS6 | integrator complex subunit 6 | 0.0161738 |
| CNOT10 | CCR4-NOT transcription complex, subunit 10 | 0.016059 |
| KIAA1671 | KIAA1671 | 0.0160356 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0160249 |
| RANBP9 | RAN binding protein 9 | 0.0160123 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0160062 |
| FAM120B | family with sequence similarity 120B | 0.0159714 |
| C8ORF44-SGK3 | C8orf44-SGK3 readthrough | 0.0159567 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0159277 |
| ANGPTL4 | angiopoietin-like 4 | 0.015925 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0159231 |
| MYO10 | myosin X | 0.0158434 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0158359 |
| JUN | jun proto-oncogene | 0.0157747 |
| ACTG1 | actin gamma 1 | 0.0157288 |
| PTMS | parathymosin | 0.0156516 |
| MYO1D | myosin ID | 0.0156352 |
| IRF1 | interferon regulatory factor 1 | 0.0156173 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0155974 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.015593 |
| TPI1 | triosephosphate isomerase 1 | 0.0155491 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.161716 |
| VIM | vimentin | -0.100476 |
| TMSB10 | thymosin beta 10 | -0.0941247 |
| RBM39 | RNA binding motif protein 39 | -0.0816372 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0800572 |
| ANXA2 | annexin A2 | -0.0791986 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0705218 |
| YAP1 | Yes-associated protein 1 | -0.0608432 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.057984 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0571031 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0567081 |
| CANX | calnexin | -0.0560166 |
| SMYD3 | SET and MYND domain containing 3 | -0.0558553 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.052737 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0520925 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0518358 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.051603 |
| OSMR | oncostatin M receptor | -0.0513503 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0494999 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0485655 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0477654 |
| SEPTIN7 | septin 7 | -0.0475533 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0473353 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0456794 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0446466 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0444882 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0434126 |
| TPX2 | TPX2, microtubule-associated | -0.0434041 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0433064 |
| WAC | WW domain containing adaptor with coiled-coil | -0.042459 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0417129 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0416951 |
| DEK | DEK proto-oncogene | -0.0416599 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0410367 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0410204 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0408272 |
| NUP58 | nucleoporin 58 | -0.0401695 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0399073 |
| VCL | vinculin | -0.0393149 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0382644 |
| ECT2 | epithelial cell transforming 2 | -0.0379246 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0378962 |
| LDHA | lactate dehydrogenase A | -0.0374271 |
| YBX3 | Y box binding protein 3 | -0.0373707 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0372358 |
| RPL35A | ribosomal protein L35a | -0.0371017 |
| CENPF | centromere protein F, 350/400kDa | -0.0368113 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.036802 |
| SNX14 | sorting nexin 14 | -0.0367041 |
| GNAS | GNAS complex locus | -0.0365646 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0364589 |
| SPAG9 | sperm associated antigen 9 | -0.0364508 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0364323 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0363624 |
| JMJD1C | jumonji domain containing 1C | -0.0356009 |
| CD44 | CD44 molecule (Indian blood group) | -0.0354983 |
| RAD51B | RAD51 paralog B | -0.0348661 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0347294 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0347225 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0346708 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.034623 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0345288 |
| PAPOLA | poly(A) polymerase alpha | -0.0341845 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0340872 |
| PARD3 | par-3 family cell polarity regulator | -0.0338014 |
| ZNF292 | zinc finger protein 292 | -0.0337584 |
| TMEM123 | transmembrane protein 123 | -0.0335101 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0330406 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0327294 |
| KIAA1328 | KIAA1328 | -0.0326063 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0325351 |
| PTMA | prothymosin, alpha | -0.0324138 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0323446 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.032148 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0319626 |
| SDC4 | syndecan 4 | -0.0317806 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0314941 |
| WDR45B | WD repeat domain 45B | -0.0314411 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314258 |
| MATR3 | matrin 3 | -0.0311533 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.031061 |
| RPL4 | ribosomal protein L4 | -0.0307339 |
| ANLN | anillin, actin binding protein | -0.0305629 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0305266 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0305029 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0304393 |
| FMNL2 | formin-like 2 | -0.0303895 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0303787 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0302305 |
| PHF20 | PHD finger protein 20 | -0.0297792 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0297636 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0295785 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0294643 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0293628 |
| ACER3 | alkaline ceramidase 3 | -0.0292947 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.029013 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0287001 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0285933 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.02843 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0283878 |
