| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD1390 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD1390_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | 0.169714 |
| HMGA2 | high mobility group AT-hook 2 | 0.0848864 |
| FN1 | fibronectin 1 | 0.0834137 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0641463 |
| STC2 | stanniocalcin 2 | 0.0528957 |
| GLIS3 | GLIS family zinc finger 3 | 0.0477129 |
| EFNA5 | ephrin-A5 | 0.0436014 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.041762 |
| AEBP2 | AE binding protein 2 | 0.0375037 |
| INTS6 | integrator complex subunit 6 | 0.0349628 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0347997 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0326677 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0314371 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0306659 |
| RAI14 | retinoic acid induced 14 | 0.0301402 |
| VCL | vinculin | 0.0272671 |
| ASPH | aspartate beta-hydroxylase | 0.0266027 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0255731 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0253358 |
| LOXL2 | lysyl oxidase-like 2 | 0.025296 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0249109 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0246566 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0246463 |
| SMAD3 | SMAD family member 3 | 0.023311 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0230921 |
| TNS3 | tensin 3 | 0.0224949 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0221667 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0220798 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0211978 |
| PALLD | palladin, cytoskeletal associated protein | 0.0211889 |
| ITGA1 | integrin, alpha 1 | 0.0208565 |
| TMEM156 | transmembrane protein 156 | 0.0207625 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0206079 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0204932 |
| FLNA | filamin A, alpha | 0.0202833 |
| RASAL2 | RAS protein activator like 2 | 0.0198479 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0195461 |
| SEPTIN9 | septin 9 | 0.0193806 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0189102 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0181505 |
| EGFR | epidermal growth factor receptor | 0.0181246 |
| PLEC | plectin | 0.0177801 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0174734 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.017365 |
| FBN1 | fibrillin 1 | 0.0172398 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0172313 |
| SYT1 | synaptotagmin I | 0.0167311 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0165109 |
| ABR | active BCR-related | 0.016445 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0160867 |
| NTN4 | netrin 4 | 0.0160598 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0159717 |
| MLPH | melanophilin | 0.015936 |
| TENM4 | teneurin transmembrane protein 4 | 0.0159298 |
| FAT1 | FAT atypical cadherin 1 | 0.015775 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0156382 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0153968 |
| PRKCA | protein kinase C, alpha | 0.0153652 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0153024 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0152844 |
| POU2F2 | POU class 2 homeobox 2 | 0.0150861 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0148877 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0148693 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0147215 |
| RANBP17 | RAN binding protein 17 | 0.0145499 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0144407 |
| GPATCH2L | G patch domain containing 2-like | 0.0144138 |
| NXN | nucleoredoxin | 0.0143599 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0142585 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0142525 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0140061 |
| CTBP2 | C-terminal binding protein 2 | 0.0137011 |
| OXR1 | oxidation resistance 1 | 0.0136519 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0135456 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0134959 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0134743 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0133891 |
| TUFT1 | tuftelin 1 | 0.0132097 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0130833 |
| CCDC138 | coiled-coil domain containing 138 | 0.0130383 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0129288 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0128113 |
| FGF18 | fibroblast growth factor 18 | 0.0127422 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 0.012657 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.012643 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0124947 |
| LRRC23 | leucine rich repeat containing 23 | 0.0124833 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0123944 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.012323 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0120316 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0120087 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0119849 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0117504 |
| NAV1 | neuron navigator 1 | 0.0117018 |
| RAD51B | RAD51 paralog B | 0.0116026 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.011525 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0114512 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0113986 |
| NBEA | neurobeachin | 0.0113951 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0112729 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.359238 |
| MT2A | metallothionein 2A | -0.122096 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.111251 |
| PTMA | prothymosin, alpha | -0.107682 |
| VIM | vimentin | -0.0904976 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0840538 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0789369 |
| FTL | ferritin, light polypeptide | -0.0772488 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0711499 |
| RPS6 | ribosomal protein S6 | -0.067791 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0670677 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0650849 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0617381 |
| TMSB10 | thymosin beta 10 | -0.0602183 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0600958 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0582187 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0550055 |
| CENPF | centromere protein F, 350/400kDa | -0.0475235 |
| CANX | calnexin | -0.0473206 |
| S100A6 | S100 calcium binding protein A6 | -0.0460475 |
| RNF145 | ring finger protein 145 | -0.0447469 |
| B2M | beta-2-microglobulin | -0.0444735 |
| SEPTIN7 | septin 7 | -0.043175 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0427996 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.041188 |
| RTN4 | reticulon 4 | -0.0409141 |
| OGA | O-GlcNAcase | -0.0406547 |
| ZNF292 | zinc finger protein 292 | -0.0398772 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0391021 |
| HLA-B | major histocompatibility complex, class I, B | -0.0389995 |
| RPLP1 | ribosomal protein, large, P1 | -0.0386873 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0386595 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0374448 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0373814 |
| RBM39 | RNA binding motif protein 39 | -0.0373316 |
| RPL35A | ribosomal protein L35a | -0.0369792 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0368653 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0367555 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0365525 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0364673 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0362271 |
| SPAG9 | sperm associated antigen 9 | -0.0362075 |
| WDR45B | WD repeat domain 45B | -0.0358555 |
| RPL12 | ribosomal protein L12 | -0.0358451 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0358263 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0339736 |
| RPS19 | ribosomal protein S19 | -0.0338552 |
| TXNIP | thioredoxin interacting protein | -0.0337293 |
| RPL37A | ribosomal protein L37a | -0.0334861 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0333843 |
| GOLGA4 | golgin A4 | -0.0328963 |
| RPS12 | ribosomal protein S12 | -0.0327865 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0327685 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0320318 |
| PGK1 | phosphoglycerate kinase 1 | -0.0311219 |
| NDRG1 | N-myc downstream regulated 1 | -0.0311191 |
| RPL26 | ribosomal protein L26 | -0.0310376 |
| RPS8 | ribosomal protein S8 | -0.0306377 |
| HELZ | helicase with zinc finger | -0.0306127 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0301583 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0300525 |
| NUP58 | nucleoporin 58 | -0.0298997 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0298793 |
| NEK7 | NIMA-related kinase 7 | -0.0292712 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0291576 |
| RPS24 | ribosomal protein S24 | -0.02854 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0283544 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0281234 |
| TFG | TRK-fused gene | -0.0280667 |
| RPL23 | ribosomal protein L23 | -0.0276856 |
| RPL9 | ribosomal protein L9 | -0.0275091 |
| RLF | rearranged L-myc fusion | -0.0267044 |
| XPO1 | exportin 1 | -0.0266495 |
| RPS21 | ribosomal protein S21 | -0.0265676 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0265346 |
| RPS16 | ribosomal protein S16 | -0.0262165 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0261613 |
| ANLN | anillin, actin binding protein | -0.0260968 |
| RPLP0 | ribosomal protein, large, P0 | -0.0259402 |
| S100A10 | S100 calcium binding protein A10 | -0.0258596 |
| RPS25 | ribosomal protein S25 | -0.0256237 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0255193 |
| COPA | coatomer protein complex, subunit alpha | -0.0253984 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.025269 |
| FAM13A | family with sequence similarity 13, member A | -0.025233 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0251843 |
| RNF24 | ring finger protein 24 | -0.0249966 |
| GNAS | GNAS complex locus | -0.0247985 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0243483 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.024317 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0242275 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0241751 |
| RAD21 | RAD21 homolog (S. pombe) | -0.024028 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0239627 |
| MKI67 | marker of proliferation Ki-67 | -0.0238443 |
| PCBP2 | poly(rC) binding protein 2 | -0.0237943 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.023574 |
| CDC27 | cell division cycle 27 | -0.0234104 |
| IER3 | immediate early response 3 | -0.0233958 |
| RBM25 | RNA binding motif protein 25 | -0.0233947 |
