AZD2858_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD2858_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.198571
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.13656
LDHA lactate dehydrogenase A 0.0925099
CDH13 cadherin 13 0.0852848
AKAP12 A kinase (PRKA) anchor protein 12 0.0743194
B2M beta-2-microglobulin 0.0737999
CSTB cystatin B (stefin B) 0.0724746
VIM vimentin 0.0705503
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0661328
PLEC plectin 0.0623999
TPM4 tropomyosin 4 0.0598882
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0537027
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.050754
TRIO trio Rho guanine nucleotide exchange factor 0.0484552
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0483781
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.046772
HDAC9 histone deacetylase 9 0.0457075
CENPF centromere protein F, 350/400kDa 0.0451861
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0378152
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0369405
MAP1B microtubule-associated protein 1B 0.0367189
ANKRD11 ankyrin repeat domain 11 0.0362547
LOC112694756 uncharaterized LOC112694756 0.0356935
TPM3 tropomyosin 3 0.0352085
MT2A metallothionein 2A 0.0349826
RPL35A ribosomal protein L35a 0.0338087
ASPH aspartate beta-hydroxylase 0.0337733
DSPP dentin sialophosphoprotein 0.0336572
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0327891
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0324034
FTL ferritin, light polypeptide 0.0320083
SLC39A11 solute carrier family 39, member 11 0.0317095
ISG15 ISG15 ubiquitin-like modifier 0.0316327
FLNA filamin A, alpha 0.0313348
TPI1 triosephosphate isomerase 1 0.0310908
EFNA5 ephrin-A5 0.0304582
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.029571
TUBB4B tubulin, beta 4B class IVb 0.0294124
EGFR epidermal growth factor receptor 0.0293864
LGALS1 lectin, galactoside-binding, soluble, 1 0.0289965
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0289781
IFI6 interferon, alpha-inducible protein 6 0.0285039
HSPH1 heat shock 105kDa/110kDa protein 1 0.0284089
IFITM3 interferon induced transmembrane protein 3 0.0281758
RPL12 ribosomal protein L12 0.0279917
FN1 fibronectin 1 0.0271722
ALCAM activated leukocyte cell adhesion molecule 0.0267148
RPS19 ribosomal protein S19 0.0265655
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0257186
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0256574
TMSB4X thymosin beta 4, X-linked 0.0255787
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0252859
RPS6 ribosomal protein S6 0.024644
ENO1 enolase 1, (alpha) 0.0243211
RPL37A ribosomal protein L37a 0.0242283
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0241469
MCL1 myeloid cell leukemia 1 0.0240989
SEPTIN7 septin 7 0.0239943
RPLP1 ribosomal protein, large, P1 0.0239501
RPLP2 ribosomal protein, large, P2 0.0237629
S100A11 S100 calcium binding protein A11 0.0235546
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.02343
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0233942
PBX3 pre-B-cell leukemia homeobox 3 0.0231703
RPS12 ribosomal protein S12 0.0229197
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0228574
RPL11 ribosomal protein L11 0.022795
RPS17 ribosomal protein S17 0.0224354
PLXNA2 plexin A2 0.0223707
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0220467
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0219322
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0216891
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0212313
DGKG diacylglycerol kinase, gamma 90kDa 0.0207778
RPL36 ribosomal protein L36 0.0206617
BZW1 basic leucine zipper and W2 domains 1 0.0205449
RND3 Rho family GTPase 3 0.0205088
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.020444
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.020169
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0200652
HSPB1 heat shock 27kDa protein 1 0.0199705
SUCNR1 succinate receptor 1 0.0199391
PODXL podocalyxin-like 0.0197526
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0196842
RPS8 ribosomal protein S8 0.0190501
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0189457
ITGA6 integrin, alpha 6 0.0188433
RPS14 ribosomal protein S14 0.0186752
SEC61G Sec61 gamma subunit 0.0185593
SAMD9 sterile alpha motif domain containing 9 0.0180758
HSPA1B heat shock 70kDa protein 1B 0.0176926
RPL23 ribosomal protein L23 0.0173318
RPLP0 ribosomal protein, large, P0 0.0173009
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0171879
LRRC17 leucine rich repeat containing 17 0.0171256
AHNAK2 AHNAK nucleoprotein 2 0.0167694
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0167208
CALD1 caldesmon 1 0.0166907
LMNA lamin A/C 0.0166809
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0165527

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.170318
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162314
FBN1 fibrillin 1 -0.15856
UBC ubiquitin C -0.136352
LOX lysyl oxidase -0.108323
COL3A1 collagen, type III, alpha 1 -0.104313
COL1A2 collagen, type I, alpha 2 -0.0868669
DLG1 discs, large homolog 1 (Drosophila) -0.0828243
FNDC3B fibronectin type III domain containing 3B -0.0766017
OGA O-GlcNAcase -0.0745987
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0695104
COL5A2 collagen, type V, alpha 2 -0.0645412
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0635052
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0606574
TMSB10 thymosin beta 10 -0.0592033
CD44 CD44 molecule (Indian blood group) -0.0579102
AUTS2 autism susceptibility candidate 2 -0.0574915
DPYSL3 dihydropyrimidinase-like 3 -0.0571168
PLAT plasminogen activator, tissue -0.0563525
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0556937
SBF2 SET binding factor 2 -0.0554614
SOD2 superoxide dismutase 2, mitochondrial -0.051264
LOXL2 lysyl oxidase-like 2 -0.0510403
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0501728
ZBTB20 zinc finger and BTB domain containing 20 -0.0473693
THBS2 thrombospondin 2 -0.0472866
STC1 stanniocalcin 1 -0.0458603
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0440196
GPC6 glypican 6 -0.044004
COL8A1 collagen, type VIII, alpha 1 -0.0436886
PSD3 pleckstrin and Sec7 domain containing 3 -0.0436271
ATP13A3 ATPase type 13A3 -0.0421544
MAP4 microtubule-associated protein 4 -0.0420068
FLNB filamin B, beta -0.0417837
NAV1 neuron navigator 1 -0.0397178
CD99 CD99 molecule -0.0378818
KIFAP3 kinesin-associated protein 3 -0.0376069
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0374811
ACTN4 actinin, alpha 4 -0.0360158
ANXA2 annexin A2 -0.0351548
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0346687
HLA-B major histocompatibility complex, class I, B -0.0344374
GLIS3 GLIS family zinc finger 3 -0.0341515
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0337836
RBM25 RNA binding motif protein 25 -0.0336256
ANKRD10 ankyrin repeat domain 10 -0.0336122
FTH1 ferritin, heavy polypeptide 1 -0.0335316
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0332407
MEIS2 Meis homeobox 2 -0.0322751
MARCHF6 membrane associated ring-CH-type finger 6 -0.0315488
PTMA prothymosin, alpha -0.0313267
FBXL7 F-box and leucine-rich repeat protein 7 -0.0310334
GLS2 glutaminase 2 (liver, mitochondrial) -0.0308324
EPAS1 endothelial PAS domain protein 1 -0.0308237
APP amyloid beta (A4) precursor protein -0.0306806
AHNAK AHNAK nucleoprotein -0.0299363
DSCAM Down syndrome cell adhesion molecule -0.0299223
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0298239
USP34 ubiquitin specific peptidase 34 -0.0297445
C1D C1D nuclear receptor corepressor -0.0294113
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0292854
TMOD1 tropomodulin 1 -0.0290639
WWTR1 WW domain containing transcription regulator 1 -0.0287688
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0287491
ANKRD36 ankyrin repeat domain 36 -0.0286826
RUNX1 runt-related transcription factor 1 -0.0284125
KDM3A lysine (K)-specific demethylase 3A -0.0283656
PRELID2 PRELI domain containing 2 -0.0281785
TTC3 tetratricopeptide repeat domain 3 -0.0280525
NF1 neurofibromin 1 -0.0279923
MT1X metallothionein 1X -0.0279194
EHBP1 EH domain binding protein 1 -0.0278295
HIP1 huntingtin interacting protein 1 -0.0275371
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0275302
NT5C2 5'-nucleotidase, cytosolic II -0.0271582
FNIP1 folliculin interacting protein 1 -0.0269735
ELL2 elongation factor, RNA polymerase II, 2 -0.0268981
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0266761
GLG1 golgi glycoprotein 1 -0.0263111
NAV2 neuron navigator 2 -0.0262467
ZEB2 zinc finger E-box binding homeobox 2 -0.0257219
TM4SF1 transmembrane 4 L six family member 1 -0.025678
OPTN optineurin -0.0253099
SLC22A23 solute carrier family 22, member 23 -0.0251296
ANKRD36C ankyrin repeat domain 36C -0.0250458
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0246686
ARL15 ADP-ribosylation factor-like 15 -0.024587
DENND5A DENN/MADD domain containing 5A -0.0244518
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0244315
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0241304
SSBP2 single-stranded DNA binding protein 2 -0.023719
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0236391
NKTR natural killer cell triggering receptor -0.0236379
NAP1L1 nucleosome assembly protein 1-like 1 -0.0235163
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0234693
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0233897
MBD5 methyl-CpG binding domain protein 5 -0.0232671
WDFY1 WD repeat and FYVE domain containing 1 -0.0230861
PXDN peroxidasin -0.0230613
KLHL24 kelch-like family member 24 -0.0230249