| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.224341 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0708187 |
| LDHA | lactate dehydrogenase A | 0.0472194 |
| TPI1 | triosephosphate isomerase 1 | 0.0441911 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0441105 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0415223 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0400897 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0338943 |
| LOC112694756 | uncharaterized LOC112694756 | 0.03336 |
| RPS12 | ribosomal protein S12 | 0.030958 |
| RPL3 | ribosomal protein L3 | 0.0309565 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0301577 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0279722 |
| CCDC200 | coiled-coil domain containing 200 | 0.0270862 |
| RPS3 | ribosomal protein S3 | 0.0266981 |
| RRM2 | ribonucleotide reductase M2 | 0.0243085 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0233965 |
| RPL13A | ribosomal protein L13a | 0.0217764 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0216294 |
| PLEC | plectin | 0.0215617 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0211638 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0210566 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0204442 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0196222 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0192168 |
| RACK1 | receptor for activated C kinase 1 | 0.0190032 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0184653 |
| RPS4X | ribosomal protein S4, X-linked | 0.0175855 |
| BRD2 | bromodomain containing 2 | 0.0172622 |
| RPL11 | ribosomal protein L11 | 0.0170543 |
| RPL7 | ribosomal protein L7 | 0.016827 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0166936 |
| RPS17 | ribosomal protein S17 | 0.0158301 |
| SERINC1 | serine incorporator 1 | 0.0157902 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0156405 |
| INTS6 | integrator complex subunit 6 | 0.0154937 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0154313 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.015387 |
| RPL37A | ribosomal protein L37a | 0.0150897 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0150035 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0149884 |
| TPM3 | tropomyosin 3 | 0.0149282 |
| HMGB2 | high mobility group box 2 | 0.0146643 |
| RPS7 | ribosomal protein S7 | 0.0145817 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0140579 |
| DSPP | dentin sialophosphoprotein | 0.0139993 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0137601 |
| RPL12 | ribosomal protein L12 | 0.0136334 |
| CAVIN1 | caveolae associated protein 1 | 0.0134245 |
| RPL7A | ribosomal protein L7a | 0.0133306 |
| YTHDC1 | YTH domain containing 1 | 0.0132915 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0132765 |
| UBB | ubiquitin B | 0.0131361 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0130368 |
| ENO1 | enolase 1, (alpha) | 0.012736 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0126266 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0125384 |
| ARRDC3 | arrestin domain containing 3 | 0.01224 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0121851 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0121425 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0120748 |
| RPL9 | ribosomal protein L9 | 0.0118397 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.0118031 |
| FTL | ferritin, light polypeptide | 0.0117753 |
| ITSN2 | intersectin 2 | 0.0115623 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0114589 |
| H1-5 | H1.5 linker histone, cluster member | 0.0114025 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0113339 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0112991 |
| LRRC23 | leucine rich repeat containing 23 | 0.0112457 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0111454 |
| INTS4 | integrator complex subunit 4 | 0.0108909 |
| PRDX1 | peroxiredoxin 1 | 0.0108848 |
| APTX | aprataxin | 0.0108646 |
| RPL23 | ribosomal protein L23 | 0.0108641 |
| SQSTM1 | sequestosome 1 | 0.0108567 |
| RLF | rearranged L-myc fusion | 0.0108419 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0107124 |
| CALU | calumenin | 0.0107117 |
| DENND5A | DENN/MADD domain containing 5A | 0.0103839 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0103095 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0101055 |
| RPS18 | ribosomal protein S18 | 0.0100645 |
| H1-4 | H1.4 linker histone, cluster member | 0.0100185 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.00994579 |
| FLNA | filamin A, alpha | 0.00987784 |
| EZR | ezrin | 0.00975963 |
| HDLBP | high density lipoprotein binding protein | 0.00975546 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.00966478 |
| RSL24D1 | ribosomal L24 domain containing 1 | 0.00964877 |
| PPME1 | protein phosphatase methylesterase 1 | 0.00958738 |
| CD164 | CD164 molecule, sialomucin | 0.0095639 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | 0.00951216 |
| SOD1 | superoxide dismutase 1, soluble | 0.00947932 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.00947664 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.00945786 |
| CPNE1 | copine I | 0.00936577 |
| CUL3 | cullin 3 | 0.0093293 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.00932363 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00932008 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.239459 |
| NLGN1 | neuroligin 1 | -0.215858 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.187225 |
| TMSB10 | thymosin beta 10 | -0.110275 |
| ACTG1 | actin gamma 1 | -0.0934739 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0877081 |
| AREG | amphiregulin | -0.0847637 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0736175 |
| MMP12 | matrix metallopeptidase 12 | -0.0729477 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0706922 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0614279 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0599025 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0596491 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0579802 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0560729 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0553708 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0546282 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0542031 |
| PFN1 | profilin 1 | -0.0537452 |
| VMP1 | vacuole membrane protein 1 | -0.0520101 |
| RASAL2 | RAS protein activator like 2 | -0.0519085 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0511293 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.049666 |
| NHSL1 | NHS-like 1 | -0.0491386 |
| PTMA | prothymosin, alpha | -0.0482347 |
| PCDH7 | protocadherin 7 | -0.0480289 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0459373 |
| BCHE | butyrylcholinesterase | -0.0452774 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0440971 |
| JMJD1C | jumonji domain containing 1C | -0.0426539 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0426275 |
| ZNF804A | zinc finger protein 804A | -0.0423341 |
| YBX3 | Y box binding protein 3 | -0.0411065 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0406651 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0400468 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0399741 |
| TMEM41B | transmembrane protein 41B | -0.0371561 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0368363 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0367877 |
| YAP1 | Yes-associated protein 1 | -0.0365973 |
| MAP1B | microtubule-associated protein 1B | -0.0359977 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0359767 |
| MKI67 | marker of proliferation Ki-67 | -0.0356395 |
| HMGA1 | high mobility group AT-hook 1 | -0.0352696 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0349703 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0346295 |
| EDARADD | EDAR-associated death domain | -0.0336398 |
| CMIP | c-Maf inducing protein | -0.033561 |
| RPS23 | ribosomal protein S23 | -0.0333935 |
| DST | dystonin | -0.0331202 |
| HMGA2 | high mobility group AT-hook 2 | -0.0327337 |
| PDGFC | platelet derived growth factor C | -0.0326944 |
| CENPF | centromere protein F, 350/400kDa | -0.0326903 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0326803 |
| RTN4 | reticulon 4 | -0.032028 |
| PTMS | parathymosin | -0.0314933 |
| ANKRD28 | ankyrin repeat domain 28 | -0.031286 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0310111 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0308345 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0307258 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0304705 |
| TMEM123 | transmembrane protein 123 | -0.0293937 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0291916 |
| POTEF | POTE ankyrin domain family, member F | -0.028843 |
| EHBP1 | EH domain binding protein 1 | -0.0285419 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0284527 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0279481 |
| NF1 | neurofibromin 1 | -0.0274799 |
| RPL8 | ribosomal protein L8 | -0.027061 |
| TGM2 | transglutaminase 2 | -0.0269008 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0268706 |
| CCN2 | cellular communication network factor 2 | -0.0266945 |
| RBMX | RNA binding motif protein, X-linked | -0.0266315 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0266092 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0264316 |
| TENM3 | teneurin transmembrane protein 3 | -0.0258061 |
| LMO7 | LIM domain 7 | -0.0256714 |
| NAV3 | neuron navigator 3 | -0.0256539 |
| RAB10 | RAB10, member RAS oncogene family | -0.0256436 |
| NEBL | nebulette | -0.0256348 |
| PRR11 | proline rich 11 | -0.0250149 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0249984 |
| KIF18B | kinesin family member 18B | -0.0248032 |
| RPS29 | ribosomal protein S29 | -0.024741 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0246528 |
| CUX1 | cut-like homeobox 1 | -0.0246268 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.024362 |
| CENPE | centromere protein E, 312kDa | -0.0242449 |
| MAP4 | microtubule-associated protein 4 | -0.02404 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0240089 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0238407 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0234567 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0228257 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0227707 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0225997 |
| RPS15 | ribosomal protein S15 | -0.0225544 |
| EGR1 | early growth response 1 | -0.0225208 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0221004 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0220997 |
| CBX3 | chromobox homolog 3 | -0.0220437 |
