AZD2858_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD2858_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.25746
LMO7 LIM domain 7 0.219137
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.128159
FTL ferritin, light polypeptide 0.12149
HSPH1 heat shock 105kDa/110kDa protein 1 0.104778
INTS6 integrator complex subunit 6 0.103977
AKAP13 A kinase (PRKA) anchor protein 13 0.08863
RNF213 ring finger protein 213 0.0878597
EPSTI1 epithelial stromal interaction 1 (breast) 0.0877893
SP100 SP100 nuclear antigen 0.0862775
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0768807
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.076423
MX2 MX dynamin-like GTPase 2 0.0750168
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0744957
ZSWIM6 zinc finger, SWIM-type containing 6 0.0696042
RIGI RNA sensor RIG-I 0.0646495
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0637982
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0616427
SMAD3 SMAD family member 3 0.0581281
GCLC glutamate-cysteine ligase, catalytic subunit 0.0540753
MX1 MX dynamin-like GTPase 1 0.0539799
DST dystonin 0.0536736
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0536088
TSHZ2 teashirt zinc finger homeobox 2 0.053292
GMDS GDP-mannose 4,6-dehydratase 0.0529875
RAB7A RAB7A, member RAS oncogene family 0.0529286
TMC5 transmembrane channel-like 5 0.0515029
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0514304
ASPH aspartate beta-hydroxylase 0.0508885
UBC ubiquitin C 0.0496971
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0496393
ANXA2 annexin A2 0.0465235
POU2F2 POU class 2 homeobox 2 0.0460047
PERP PERP, TP53 apoptosis effector 0.0459597
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0450962
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0445705
MAP7 microtubule-associated protein 7 0.0423087
HKDC1 hexokinase domain containing 1 0.0422736
CATSPERB catsper channel auxiliary subunit beta 0.0418213
TRIO trio Rho guanine nucleotide exchange factor 0.0417201
TJP1 tight junction protein 1 0.0408146
IGFBP3 insulin-like growth factor binding protein 3 0.040595
RSAD2 radical S-adenosyl methionine domain containing 2 0.0399991
SAMD9 sterile alpha motif domain containing 9 0.0389588
TM4SF19 transmembrane 4 L six family member 19 0.0385656
LCN2 lipocalin 2 0.0382025
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0379242
SIK3 SIK family kinase 3 0.0373993
SEPTIN9 septin 9 0.0369215
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0368893
PKM pyruvate kinase, muscle 0.0367029
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0366037
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0358436
HSPA1B heat shock 70kDa protein 1B 0.0341797
DIAPH1 diaphanous-related formin 1 0.0339922
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0339062
KYNU kynureninase 0.0336887
STS steroid sulfatase (microsomal), isozyme S 0.0333323
SPATA13 spermatogenesis associated 13 0.0332756
MAML2 mastermind-like 2 (Drosophila) 0.0330345
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0326196
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0316532
MCU mitochondrial calcium uniporter 0.0316282
NPSR1 neuropeptide S receptor 1 0.031508
LYZ lysozyme 0.0309604
PLSCR2 phospholipid scramblase 2 0.0304153
TXNRD1 thioredoxin reductase 1 0.0301077
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0297682
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0293057
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0288067
MYH14 myosin, heavy chain 14, non-muscle 0.0286052
MCL1 myeloid cell leukemia 1 0.0285745
BCL2L1 BCL2-like 1 0.0285739
KTN1 kinectin 1 (kinesin receptor) 0.0283763
POF1B premature ovarian failure, 1B 0.0283154
ERBIN erbb2 interacting protein 0.028092
JAK1 Janus kinase 1 0.0278098
ITGA6 integrin, alpha 6 0.0275562
TOX3 TOX high mobility group box family member 3 0.0275135
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.027483
AREG amphiregulin 0.0274763
IFI6 interferon, alpha-inducible protein 6 0.0274055
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.027221
GK glycerol kinase 0.0264314
PCED1B PC-esterase domain containing 1B 0.0255692
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0255663
UBAP2 ubiquitin associated protein 2 0.0255087
CDHR2 cadherin-related family member 2 0.0254495
RASAL2 RAS protein activator like 2 0.0253666
NCEH1 neutral cholesterol ester hydrolase 1 0.0246862
ENO1 enolase 1, (alpha) 0.0243334
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0239517
LPP LIM domain containing preferred translocation partner in lipoma 0.0237001
APOL1 apolipoprotein L, 1 0.0236082
EXT1 exostosin glycosyltransferase 1 0.0229847
RBM47 RNA binding motif protein 47 0.02241
KRT18 keratin 18, type I 0.0223307
IRS2 insulin receptor substrate 2 0.0221776
HSPA8 heat shock 70kDa protein 8 0.0220675
ZHX2 zinc fingers and homeoboxes 2 0.0219275

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.16754
RNF43 ring finger protein 43 -0.0808698
RHOBTB3 Rho-related BTB domain containing 3 -0.0808064
RUNX1 runt-related transcription factor 1 -0.0773223
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0708044
PTBP3 polypyrimidine tract binding protein 3 -0.0653743
NDRG1 N-myc downstream regulated 1 -0.0649275
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.060065
TXNIP thioredoxin interacting protein -0.0593445
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0542961
AHI1 Abelson helper integration site 1 -0.0528061
GOLGA4 golgin A4 -0.0526185
SREBF2 sterol regulatory element binding transcription factor 2 -0.0524067
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0516975
DSCAM Down syndrome cell adhesion molecule -0.0507495
PTMA prothymosin, alpha -0.0506766
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0503221
ZMYM2 zinc finger, MYM-type 2 -0.0498102
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0476242
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0443426
DIAPH3 diaphanous-related formin 3 -0.0440253
RBM39 RNA binding motif protein 39 -0.0436864
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0433142
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0425669
PTEN phosphatase and tensin homolog -0.0424239
SBF2 SET binding factor 2 -0.0421537
RPS6 ribosomal protein S6 -0.0409388
NRIP1 nuclear receptor interacting protein 1 -0.0402145
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0399344
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0389693
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0387449
GRAMD2B GRAM domain containing 2B -0.0382604
EHF ets homologous factor -0.0379055
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0366732
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0365302
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0361754
RNF149 ring finger protein 149 -0.036002
CD46 CD46 molecule, complement regulatory protein -0.0357257
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0353167
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0352077
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0348973
MCTP2 multiple C2 domains, transmembrane 2 -0.0344177
MKI67 marker of proliferation Ki-67 -0.0336648
PRELID2 PRELI domain containing 2 -0.0335049
ACBD3 acyl-CoA binding domain containing 3 -0.0334318
H1-0 H1.0 linker histone -0.0328697
TMPRSS4 transmembrane protease, serine 4 -0.032818
GNAS GNAS complex locus -0.0326621
BHLHE40 basic helix-loop-helix family, member e40 -0.0326041
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0324801
FNDC3A fibronectin type III domain containing 3A -0.0322033
TC2N tandem C2 domains, nuclear -0.0320702
YEATS2 YEATS domain containing 2 -0.0312252
TTC3 tetratricopeptide repeat domain 3 -0.0305726
CCNL1 cyclin L1 -0.0305047
TPT1 tumor protein, translationally-controlled 1 -0.0304727
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0297005
TMEM51 transmembrane protein 51 -0.029635
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0295669
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0293011
AKAP9 A kinase (PRKA) anchor protein 9 -0.028909
MBNL2 muscleblind-like splicing regulator 2 -0.0285747
HBS1L HBS1-like translational GTPase -0.0281876
SMC4 structural maintenance of chromosomes 4 -0.0280841
KDM3A lysine (K)-specific demethylase 3A -0.0278945
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0278793
TRIM2 tripartite motif containing 2 -0.0277805
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0277635
RBM25 RNA binding motif protein 25 -0.0275335
NCOR1 nuclear receptor corepressor 1 -0.0275319
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0274958
STK24 serine/threonine kinase 24 -0.0271563
TSC22D2 TSC22 domain family, member 2 -0.0270518
OGA O-GlcNAcase -0.0268138
KMT2C lysine (K)-specific methyltransferase 2C -0.0266441
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0265874
RREB1 ras responsive element binding protein 1 -0.0265868
MORF4L2 mortality factor 4 like 2 -0.0263263
TMEM263 transmembrane protein 263 -0.0260126
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0259306
PDIA3 protein disulfide isomerase family A, member 3 -0.0259
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0258171
SEC24D SEC24 family member D -0.0256324
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0255687
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0254879
CALU calumenin -0.025338
RAD21 RAD21 homolog (S. pombe) -0.0252819
PRRC1 proline-rich coiled-coil 1 -0.0250624
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0248519
SEC31A SEC31 homolog A (S. cerevisiae) -0.0247945
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0247761
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0247645
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0247421
ACTN4 actinin, alpha 4 -0.024709
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0245916
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0243854
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0243478
SPG11 spastic paraplegia 11 (autosomal recessive) -0.02434
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0242829
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0241591