| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.150285 |
| PLEC | plectin | 0.138144 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.125968 |
| COL6A3 | collagen, type VI, alpha 3 | 0.125027 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0909573 |
| LDHA | lactate dehydrogenase A | 0.0908769 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0844852 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0795891 |
| ENO1 | enolase 1, (alpha) | 0.0600085 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0570785 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0518608 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0489033 |
| RPL3 | ribosomal protein L3 | 0.0483932 |
| AHNAK | AHNAK nucleoprotein | 0.0435691 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0384434 |
| FLNA | filamin A, alpha | 0.0381422 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0381069 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0380615 |
| MYO10 | myosin X | 0.0377714 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0365062 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0349846 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0334807 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0334753 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0332195 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0310044 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0307922 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0306945 |
| CALR | calreticulin | 0.0306087 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0305239 |
| COL5A1 | collagen, type V, alpha 1 | 0.0300259 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0296853 |
| SQSTM1 | sequestosome 1 | 0.0296113 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0275904 |
| HYOU1 | hypoxia up-regulated 1 | 0.0273258 |
| RACK1 | receptor for activated C kinase 1 | 0.0266285 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0265803 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0259478 |
| VEGFA | vascular endothelial growth factor A | 0.0251218 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0249913 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0239838 |
| RPS4X | ribosomal protein S4, X-linked | 0.0239638 |
| POSTN | periostin, osteoblast specific factor | 0.0232279 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0229436 |
| MSN | moesin | 0.0228075 |
| B2M | beta-2-microglobulin | 0.0224656 |
| TLN1 | talin 1 | 0.0223264 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0222193 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0220728 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0218454 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.021591 |
| JAG1 | jagged 1 | 0.0208545 |
| FAT1 | FAT atypical cadherin 1 | 0.0208469 |
| RPL7 | ribosomal protein L7 | 0.020784 |
| FAM107B | family with sequence similarity 107, member B | 0.0201058 |
| SFPQ | splicing factor proline/glutamine-rich | 0.020028 |
| RPL23 | ribosomal protein L23 | 0.0196523 |
| PCM1 | pericentriolar material 1 | 0.0194713 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0194169 |
| CENPF | centromere protein F, 350/400kDa | 0.0192473 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0191156 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0185811 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.0183283 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0181691 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0179691 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0177896 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0177219 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0174787 |
| POLR3D | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 0.0174165 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0174004 |
| CCDC200 | coiled-coil domain containing 200 | 0.0173885 |
| MLF1 | myeloid leukemia factor 1 | 0.0172318 |
| H1-4 | H1.4 linker histone, cluster member | 0.0172302 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0170681 |
| CANX | calnexin | 0.0168772 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0167437 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0167119 |
| SDC2 | syndecan 2 | 0.0166114 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0165651 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0165073 |
| TPI1 | triosephosphate isomerase 1 | 0.0164618 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 0.0163528 |
| SETBP1 | SET binding protein 1 | 0.0162929 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.0159998 |
| SBDS | Shwachman-Bodian-Diamond syndrome | 0.0158672 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0157025 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0155882 |
| SVIL | supervillin | 0.0155822 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0155072 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0154885 |
| PCBP2 | poly(rC) binding protein 2 | 0.0153724 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0153229 |
| RPS20 | ribosomal protein S20 | 0.0153215 |
| TPM3 | tropomyosin 3 | 0.0153105 |
| RND3 | Rho family GTPase 3 | 0.0152118 |
| NCOR2 | nuclear receptor corepressor 2 | 0.015115 |
| RPS2 | ribosomal protein S2 | 0.0151139 |
| ARCN1 | archain 1 | 0.0150862 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0148391 |
| JUN | jun proto-oncogene | 0.0146991 |
| RBM33 | RNA binding motif protein 33 | 0.0145914 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.272238 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.243878 |
| VIM | vimentin | -0.197077 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.164699 |
| NDRG1 | N-myc downstream regulated 1 | -0.136145 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.117964 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.105357 |
| PTMA | prothymosin, alpha | -0.0956836 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0932158 |
| FTL | ferritin, light polypeptide | -0.0820467 |
| IER3 | immediate early response 3 | -0.08137 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0811137 |
| TMSB10 | thymosin beta 10 | -0.0792567 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0777255 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0648931 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.062719 |
| DPYD | dihydropyrimidine dehydrogenase | -0.059885 |
| HLA-B | major histocompatibility complex, class I, B | -0.0594986 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.057809 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0573063 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0564974 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0553354 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0515461 |
| RPL35A | ribosomal protein L35a | -0.0475284 |
| FN1 | fibronectin 1 | -0.047072 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0450351 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0449612 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0440517 |
| SBF2 | SET binding factor 2 | -0.0439476 |
| CADM1 | cell adhesion molecule 1 | -0.0432176 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0429043 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0422176 |
| MT1X | metallothionein 1X | -0.041872 |
| LOXL2 | lysyl oxidase-like 2 | -0.0417762 |
| ADM | adrenomedullin | -0.0408798 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0406615 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0399464 |
| PTK2 | protein tyrosine kinase 2 | -0.0372776 |
| SLC38A2 | solute carrier family 38, member 2 | -0.03698 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0368909 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0361465 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0352072 |
| PRELID2 | PRELI domain containing 2 | -0.0349696 |
| MAP1B | microtubule-associated protein 1B | -0.0346596 |
| HIP1 | huntingtin interacting protein 1 | -0.03445 |
| ACTG1 | actin gamma 1 | -0.0338991 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0336211 |
| ATP13A3 | ATPase type 13A3 | -0.0333245 |
| SETD5 | SET domain containing 5 | -0.0318801 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0315699 |
| RTN4 | reticulon 4 | -0.0315386 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0313605 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0302334 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0302266 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0297184 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0292705 |
| VCAN | versican | -0.0292229 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291922 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0291737 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0290148 |
| IL6ST | interleukin 6 signal transducer | -0.0289738 |
| TPM4 | tropomyosin 4 | -0.0288708 |
| CCNL1 | cyclin L1 | -0.0284974 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0283337 |
| NRP1 | neuropilin 1 | -0.0283287 |
| COG5 | component of oligomeric golgi complex 5 | -0.0281338 |
| BBX | bobby sox homolog (Drosophila) | -0.0279409 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0278467 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0266581 |
| NF1 | neurofibromin 1 | -0.0265747 |
| COL1A2 | collagen, type I, alpha 2 | -0.0264172 |
| RAD51B | RAD51 paralog B | -0.0263301 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0262561 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0262427 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0260118 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0258817 |
| MTDH | metadherin | -0.0258501 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0258277 |
| GOLGA4 | golgin A4 | -0.0256841 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0256514 |
| CLINT1 | clathrin interactor 1 | -0.025596 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.025512 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0253985 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0253485 |
| NREP | neuronal regeneration related protein | -0.0251296 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0247018 |
| EVI5 | ecotropic viral integration site 5 | -0.0245517 |
| THY1 | Thy-1 cell surface antigen | -0.0243793 |
| PDE10A | phosphodiesterase 10A | -0.0243715 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0242409 |
| BNC2 | basonuclin 2 | -0.0238684 |
| RPS25 | ribosomal protein S25 | -0.0238488 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0237245 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0235926 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0235423 |
| SMYD3 | SET and MYND domain containing 3 | -0.0234326 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0233376 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0233222 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0232186 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0231753 |
