AZD2858_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD2858_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.169306
AKAP12 A kinase (PRKA) anchor protein 12 0.136537
SAMD4A sterile alpha motif domain containing 4A 0.101791
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0955095
DSPP dentin sialophosphoprotein 0.0795383
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0777828
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0776701
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0742384
GPC6 glypican 6 0.0740195
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0698162
ERRFI1 ERBB receptor feedback inhibitor 1 0.0671542
EXT1 exostosin glycosyltransferase 1 0.0666952
ENO1 enolase 1, (alpha) 0.0608559
SVIL supervillin 0.0597343
ATXN1 ataxin 1 0.0574001
KIF21A kinesin family member 21A 0.0547305
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0472916
NAP1L1 nucleosome assembly protein 1-like 1 0.0453725
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0442081
DST dystonin 0.0424231
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0421868
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0417913
CRY1 cryptochrome circadian clock 1 0.0393067
UBC ubiquitin C 0.0380615
TPM4 tropomyosin 4 0.0333129
FOXP1 forkhead box P1 0.0328875
RUNX1 runt-related transcription factor 1 0.031995
PAWR PRKC, apoptosis, WT1, regulator 0.0306378
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0303101
DTNA dystrobrevin, alpha 0.0292881
GCLC glutamate-cysteine ligase, catalytic subunit 0.028922
APLP2 amyloid beta (A4) precursor-like protein 2 0.0280091
PARD3 par-3 family cell polarity regulator 0.0275337
ACSL3 acyl-CoA synthetase long-chain family member 3 0.027504
ZBTB20 zinc finger and BTB domain containing 20 0.0272753
KYNU kynureninase 0.027199
EHBP1 EH domain binding protein 1 0.0270628
FRMD5 FERM domain containing 5 0.0267734
MBNL2 muscleblind-like splicing regulator 2 0.0266781
STK17A serine/threonine kinase 17a 0.0265757
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0257175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0255345
ITGA6 integrin, alpha 6 0.0250807
HSPA8 heat shock 70kDa protein 8 0.025074
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0247783
MCL1 myeloid cell leukemia 1 0.0247291
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0247284
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0246355
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0245754
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0242893
DUSP6 dual specificity phosphatase 6 0.0242498
ZSWIM6 zinc finger, SWIM-type containing 6 0.0241144
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0237325
DOCK4 dedicator of cytokinesis 4 0.0235703
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.023445
CEMIP2 cell migration inducing hyaluronidase 2 0.0234341
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0234062
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226949
PDLIM5 PDZ and LIM domain 5 0.0219673
GOLGB1 golgin B1 0.0219508
JMJD1C jumonji domain containing 1C 0.0219334
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0217531
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0215296
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0213611
FAM107B family with sequence similarity 107, member B 0.0213219
ARHGAP21 Rho GTPase activating protein 21 0.0208122
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0207476
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0207359
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207129
MBNL1 muscleblind-like splicing regulator 1 0.0206154
ZBTB38 zinc finger and BTB domain containing 38 0.0205897
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0204833
GMDS GDP-mannose 4,6-dehydratase 0.0201599
TRIP12 thyroid hormone receptor interactor 12 0.0200006
ABAT 4-aminobutyrate aminotransferase 0.0199985
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0199502
EEF2 eukaryotic translation elongation factor 2 0.0197838
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0196957
PTPRK protein tyrosine phosphatase, receptor type, K 0.0196553
AKAP13 A kinase (PRKA) anchor protein 13 0.0195721
ARL15 ADP-ribosylation factor-like 15 0.0195214
LCOR ligand dependent nuclear receptor corepressor 0.0194184
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0193673
LDHA lactate dehydrogenase A 0.019361
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.019225
TUSC3 tumor suppressor candidate 3 0.0192019
HSPA1A heat shock 70kDa protein 1A 0.0191928
HDAC4 histone deacetylase 4 0.018836
PLEC plectin 0.0187468
LOC112694756 uncharaterized LOC112694756 0.0187129
ASPH aspartate beta-hydroxylase 0.0186406
KAT6B K(lysine) acetyltransferase 6B 0.0185445
MALRD1 MAM and LDL receptor class A domain containing 1 0.0184578
KMT2C lysine (K)-specific methyltransferase 2C 0.0183345
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0181959
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0181803
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0179815
MAP1B microtubule-associated protein 1B 0.0178118
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0177514
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0177162

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.280924
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.236811
C3 complement component 3 -0.167663
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.110069
MT2A metallothionein 2A -0.0945648
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0811237
TPT1 tumor protein, translationally-controlled 1 -0.0677919
APOB apolipoprotein B -0.0649947
TIMP1 TIMP metallopeptidase inhibitor 1 -0.062535
RPS12 ribosomal protein S12 -0.0580499
SLC38A2 solute carrier family 38, member 2 -0.0537325
RPL37A ribosomal protein L37a -0.0493577
RPS19 ribosomal protein S19 -0.0473776
DLC1 DLC1 Rho GTPase activating protein -0.0444929
HMGA1 high mobility group AT-hook 1 -0.0441434
TMSB10 thymosin beta 10 -0.0435009
DDIT4 DNA-damage-inducible transcript 4 -0.0420878
RPL11 ribosomal protein L11 -0.0412435
RPS8 ribosomal protein S8 -0.0410353
NKD1 naked cuticle homolog 1 (Drosophila) -0.0397909
RPS25 ribosomal protein S25 -0.0363248
RPL31 ribosomal protein L31 -0.0348854
APOE apolipoprotein E -0.0341648
RPL7A ribosomal protein L7a -0.0323186
PTMA prothymosin, alpha -0.0318327
RPS6 ribosomal protein S6 -0.0314987
NDRG1 N-myc downstream regulated 1 -0.0308038
MAML2 mastermind-like 2 (Drosophila) -0.0307321
RPS29 ribosomal protein S29 -0.0307125
RPLP2 ribosomal protein, large, P2 -0.0294676
AMBP alpha-1-microglobulin/bikunin precursor -0.0293271
ELL2 elongation factor, RNA polymerase II, 2 -0.0287693
FBF1 Fas (TNFRSF6) binding factor 1 -0.0287084
B2M beta-2-microglobulin -0.0282051
EML4 echinoderm microtubule associated protein like 4 -0.0281042
RPS21 ribosomal protein S21 -0.0280908
GOLGA4 golgin A4 -0.0276361
TRIM26 tripartite motif containing 26 -0.0273824
RBM25 RNA binding motif protein 25 -0.0257471
EIF1 eukaryotic translation initiation factor 1 -0.0248577
RPS10 ribosomal protein S10 -0.0243517
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0236543
RPS24 ribosomal protein S24 -0.0236492
GDF15 growth differentiation factor 15 -0.0234458
RPL35A ribosomal protein L35a -0.0234335
PTCHD4 patched domain containing 4 -0.0229992
A2M alpha-2-macroglobulin -0.0224809
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0219071
RPLP1 ribosomal protein, large, P1 -0.0218993
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0214681
RPL36A ribosomal protein L36a -0.0213925
RPL26 ribosomal protein L26 -0.0211188
VDAC1 voltage-dependent anion channel 1 -0.0210357
APOA2 apolipoprotein A-II -0.0208225
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0207575
RPL5 ribosomal protein L5 -0.0204893
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0204278
FN1 fibronectin 1 -0.0202531
RPS17 ribosomal protein S17 -0.0201537
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0198684
CST3 cystatin C -0.0196835
RPL28 ribosomal protein L28 -0.0186728
CCNL1 cyclin L1 -0.018189
EGR1 early growth response 1 -0.018089
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.018023
IER3 immediate early response 3 -0.0180154
SOD2 superoxide dismutase 2, mitochondrial -0.018006
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0178309
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0177422
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0177277
FBXO11 F-box protein 11 -0.0174513
VEGFA vascular endothelial growth factor A -0.0174286
RPS14 ribosomal protein S14 -0.017261
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0169647
MALT1 MALT1 paracaspase -0.016874
FNDC3B fibronectin type III domain containing 3B -0.0167067
RAI14 retinoic acid induced 14 -0.0165973
BRD2 bromodomain containing 2 -0.0165846
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0165237
CYB5R3 cytochrome b5 reductase 3 -0.0165009
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.016343
MBNL3 muscleblind-like splicing regulator 3 -0.01633
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0163269
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0162241
ZFHX3 zinc finger homeobox 3 -0.016082
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0159528
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.0158155
TOX3 TOX high mobility group box family member 3 -0.0157686
ACTG1 actin gamma 1 -0.0157523
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0155969
CD2AP CD2-associated protein -0.0155211
LCN2 lipocalin 2 -0.0154227
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0152968
H1-0 H1.0 linker histone -0.0152774
PGK1 phosphoglycerate kinase 1 -0.0150662
CSDE1 cold shock domain containing E1, RNA-binding -0.0150402
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.014924
WTAP Wilms tumor 1 associated protein -0.014847
CRLS1 cardiolipin synthase 1 -0.0147248
RPS16 ribosomal protein S16 -0.0147201