AZD2858_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD2858_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.18031
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.171494
PLEC plectin 0.141596
LMO7 LIM domain 7 0.115864
MAML2 mastermind-like 2 (Drosophila) 0.099957
B2M beta-2-microglobulin 0.0981442
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0944475
ITGA6 integrin, alpha 6 0.092767
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0890779
EZR ezrin 0.0855913
ENO1 enolase 1, (alpha) 0.0802142
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0766958
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0736668
LCN2 lipocalin 2 0.0730225
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0727817
GMDS GDP-mannose 4,6-dehydratase 0.070619
MYOF myoferlin 0.0677432
KRT18 keratin 18, type I 0.0659255
ASPH aspartate beta-hydroxylase 0.0637903
RPL23 ribosomal protein L23 0.0636522
IFI6 interferon, alpha-inducible protein 6 0.0624997
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0620033
CEMIP cell migration inducing protein, hyaluronan binding 0.0605983
ANXA2 annexin A2 0.0586814
LDHA lactate dehydrogenase A 0.0576772
LOC112694756 uncharaterized LOC112694756 0.0548312
LAMA4 laminin, alpha 4 0.0539487
FAT1 FAT atypical cadherin 1 0.0529073
MYO1E myosin IE 0.0525276
TJP1 tight junction protein 1 0.0518499
IFI27 interferon, alpha-inducible protein 27 0.0512456
SQSTM1 sequestosome 1 0.0471731
RPS25 ribosomal protein S25 0.0464774
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0462728
RPS12 ribosomal protein S12 0.0461689
SEPTIN9 septin 9 0.0457717
MYH9 myosin, heavy chain 9, non-muscle 0.0456455
EMP1 epithelial membrane protein 1 0.0455663
ERRFI1 ERBB receptor feedback inhibitor 1 0.0445044
PTPRK protein tyrosine phosphatase, receptor type, K 0.0443164
INTS6 integrator complex subunit 6 0.0441688
PKM pyruvate kinase, muscle 0.0440421
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0428287
MBNL2 muscleblind-like splicing regulator 2 0.0424562
APLP2 amyloid beta (A4) precursor-like protein 2 0.0421499
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0421309
FNDC3B fibronectin type III domain containing 3B 0.0418512
RPS17 ribosomal protein S17 0.041754
RRM2 ribonucleotide reductase M2 0.0411005
RPL37A ribosomal protein L37a 0.0409767
PGK1 phosphoglycerate kinase 1 0.0408981
TPI1 triosephosphate isomerase 1 0.0405562
SMAD3 SMAD family member 3 0.0404595
EFNA5 ephrin-A5 0.0402866
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0400989
CUX1 cut-like homeobox 1 0.0394433
TPM3 tropomyosin 3 0.039291
PDIA3 protein disulfide isomerase family A, member 3 0.038107
HYOU1 hypoxia up-regulated 1 0.037913
ANXA1 annexin A1 0.0377754
CDK6 cyclin-dependent kinase 6 0.0376456
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0375938
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0371869
RPL35A ribosomal protein L35a 0.0369413
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0364884
MACC1 metastasis associated in colon cancer 1 0.036302
GDA guanine deaminase 0.0360653
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0358529
KLHL29 kelch-like family member 29 0.0357789
RNF213 ring finger protein 213 0.0356046
FLNB filamin B, beta 0.0355198
NCEH1 neutral cholesterol ester hydrolase 1 0.0352371
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0348066
ZSWIM6 zinc finger, SWIM-type containing 6 0.0347975
CATSPERB catsper channel auxiliary subunit beta 0.0344561
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0344249
HLA-A major histocompatibility complex, class I, A 0.0340165
PDLIM5 PDZ and LIM domain 5 0.0337217
TPM4 tropomyosin 4 0.0333491
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0330917
SIK3 SIK family kinase 3 0.0327172
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0326522
EHBP1 EH domain binding protein 1 0.0326278
MCL1 myeloid cell leukemia 1 0.0326012
RPS3 ribosomal protein S3 0.0323599
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0323414
DSPP dentin sialophosphoprotein 0.0323182
MYH14 myosin, heavy chain 14, non-muscle 0.0320986
CTBP2 C-terminal binding protein 2 0.0320833
RPL3 ribosomal protein L3 0.03153
MCU mitochondrial calcium uniporter 0.0311497
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0311226
POTEF POTE ankyrin domain family, member F 0.0309914
HDAC9 histone deacetylase 9 0.0301766
GCLC glutamate-cysteine ligase, catalytic subunit 0.0301461
UBASH3B ubiquitin associated and SH3 domain containing B 0.0301032
MYO5B myosin VB 0.0297468
AHNAK AHNAK nucleoprotein 0.0296871
EDN1 endothelin 1 0.0293091
EEF2 eukaryotic translation elongation factor 2 0.0287772

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144204
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0898885
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0827465
GARS1 glycyl-tRNA synthetase 1 -0.057316
H1-0 H1.0 linker histone -0.0571894
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0540155
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0515165
INSIG1 insulin induced gene 1 -0.0512589
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0502668
RBM39 RNA binding motif protein 39 -0.0491443
KDM3A lysine (K)-specific demethylase 3A -0.0478416
ANLN anillin, actin binding protein -0.0475071
CD2AP CD2-associated protein -0.0464357
SOS1 son of sevenless homolog 1 (Drosophila) -0.046179
ZNF292 zinc finger protein 292 -0.0451705
CLTC clathrin, heavy chain (Hc) -0.0445098
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0442059
AGR2 anterior gradient 2 -0.0440403
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0431177
DSCAM Down syndrome cell adhesion molecule -0.0429192
AKAP9 A kinase (PRKA) anchor protein 9 -0.042281
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0419366
RAB1A RAB1A, member RAS oncogene family -0.0408996
TMSB10 thymosin beta 10 -0.0395903
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0395302
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.038102
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0376218
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0375555
RB1CC1 RB1-inducible coiled-coil 1 -0.0374642
BIRC6 baculoviral IAP repeat containing 6 -0.0373599
DLG1 discs, large homolog 1 (Drosophila) -0.0372168
NF1 neurofibromin 1 -0.0371404
AVL9 AVL9 homolog (S. cerevisiase) -0.0365444
PDIA4 protein disulfide isomerase family A, member 4 -0.0364009
EPCAM epithelial cell adhesion molecule -0.0363649
RRBP1 ribosome binding protein 1 -0.0351389
PHIP pleckstrin homology domain interacting protein -0.0350909
ZFAND3 zinc finger, AN1-type domain 3 -0.0349212
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0344109
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0341682
COG5 component of oligomeric golgi complex 5 -0.0332076
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0331061
ZC3H12B zinc finger CCCH-type containing 12B -0.0329051
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0328162
MUC17 mucin 17, cell surface associated -0.0322116
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0313005
KMT2A lysine (K)-specific methyltransferase 2A -0.0311703
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0311469
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0311326
PRSS3 protease, serine, 3 -0.0310834
NCOR1 nuclear receptor corepressor 1 -0.0307543
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0307532
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0304781
EIF1 eukaryotic translation initiation factor 1 -0.0297901
ALDOC aldolase C, fructose-bisphosphate -0.0295869
WASF2 WAS protein family, member 2 -0.0295406
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0291264
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0284725
PIAS1 protein inhibitor of activated STAT, 1 -0.0284107
RNF43 ring finger protein 43 -0.0283896
ACTG1 actin gamma 1 -0.028172
DIAPH3 diaphanous-related formin 3 -0.0278575
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0277776
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0276037
DSG2 desmoglein 2 -0.0275721
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0275586
UBE4A ubiquitination factor E4A -0.0270935
ZCCHC7 zinc finger, CCHC domain containing 7 -0.027008
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0268336
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0267712
TMEM45B transmembrane protein 45B -0.0266078
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0265393
CDK19 cyclin-dependent kinase 19 -0.0260606
ACBD3 acyl-CoA binding domain containing 3 -0.0259308
RLF rearranged L-myc fusion -0.0259054
GOLGA4 golgin A4 -0.0258426
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0258207
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0257427
RPL8 ribosomal protein L8 -0.025619
PREPL prolyl endopeptidase-like -0.0255975
S100A10 S100 calcium binding protein A10 -0.0255807
XRN1 5'-3' exoribonuclease 1 -0.0250906
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0250805
SMC5 structural maintenance of chromosomes 5 -0.0250312
ESRP1 epithelial splicing regulatory protein 1 -0.0249191
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0246463
SARAF store-operated calcium entry-associated regulatory factor -0.0246362
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0245366
DENND4C DENN/MADD domain containing 4C -0.0244659
MSMO1 methylsterol monooxygenase 1 -0.0243904
ATP11B ATPase, class VI, type 11B -0.0243359
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0242772
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0242565
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0241826
GSK3B glycogen synthase kinase 3 beta -0.0241238
RSF1 remodeling and spacing factor 1 -0.0240532
ZMYM2 zinc finger, MYM-type 2 -0.0238728
TMPRSS4 transmembrane protease, serine 4 -0.0236967
NCOA6 nuclear receptor coactivator 6 -0.023451
RPS2 ribosomal protein S2 -0.0234322