| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHA | lactate dehydrogenase A | 0.0992998 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0981038 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0552542 |
| PLEC | plectin | 0.0470493 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0458474 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0362874 |
| RPL3 | ribosomal protein L3 | 0.0332358 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0309826 |
| ASPH | aspartate beta-hydroxylase | 0.0297515 |
| FAT1 | FAT atypical cadherin 1 | 0.0289532 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0284014 |
| DSPP | dentin sialophosphoprotein | 0.0278961 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.02737 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0265986 |
| TPM3 | tropomyosin 3 | 0.0244884 |
| ENO1 | enolase 1, (alpha) | 0.0227097 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220327 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0212001 |
| KRT18 | keratin 18, type I | 0.0201892 |
| MT2A | metallothionein 2A | 0.0200231 |
| TPM4 | tropomyosin 4 | 0.0197111 |
| RPS12 | ribosomal protein S12 | 0.0187771 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0175481 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0156725 |
| INTS6 | integrator complex subunit 6 | 0.0151568 |
| FLNA | filamin A, alpha | 0.0146998 |
| RPL13A | ribosomal protein L13a | 0.0146825 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0141829 |
| HYOU1 | hypoxia up-regulated 1 | 0.0141337 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0140457 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0138997 |
| TMSB4X | thymosin beta 4, X-linked | 0.0135519 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0133861 |
| LOC112694756 | uncharaterized LOC112694756 | 0.013345 |
| RPS18 | ribosomal protein S18 | 0.0130753 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0130573 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.012994 |
| H1-4 | H1.4 linker histone, cluster member | 0.0126458 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0126415 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0125385 |
| LMO7 | LIM domain 7 | 0.012322 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0122255 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.012194 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0121018 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.0120963 |
| RPL37A | ribosomal protein L37a | 0.0116379 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0116372 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | 0.0109674 |
| TPI1 | triosephosphate isomerase 1 | 0.0108979 |
| CDC37 | cell division cycle 37 | 0.0106777 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0104379 |
| TMF1 | TATA element modulatory factor 1 | 0.0104002 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0103965 |
| GOLGA2 | golgin A2 | 0.0102581 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0101834 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0101666 |
| PRDX1 | peroxiredoxin 1 | 0.0101423 |
| GOLGA3 | golgin A3 | 0.0101372 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.00984414 |
| SEC24D | SEC24 family member D | 0.00984064 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.00980025 |
| MYOF | myoferlin | 0.00970114 |
| HLA-E | major histocompatibility complex, class I, E | 0.00969698 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.00963682 |
| MCL1 | myeloid cell leukemia 1 | 0.00955876 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | 0.00953848 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00951432 |
| HDLBP | high density lipoprotein binding protein | 0.00950435 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.00950018 |
| VIM | vimentin | 0.00944918 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.00943553 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00940909 |
| OCIAD2 | OCIA domain containing 2 | 0.00940397 |
| TBX3 | T-box 3 | 0.00939119 |
| FN1 | fibronectin 1 | 0.00935715 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0092607 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0092527 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0092012 |
| RAN | RAN, member RAS oncogene family | 0.00917352 |
| UBB | ubiquitin B | 0.00902631 |
| AHSA1 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) | 0.00902385 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00902198 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.00894498 |
| CAPRIN2 | caprin family member 2 | 0.00894305 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00893249 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.00889319 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.00876086 |
| DST | dystonin | 0.00875036 |
| PRR5L | proline rich 5 like | 0.00857878 |
| EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | 0.00851716 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00848725 |
| FTL | ferritin, light polypeptide | 0.00841624 |
| ZNF800 | zinc finger protein 800 | 0.00835495 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00823959 |
| RRM2 | ribonucleotide reductase M2 | 0.00823915 |
| RO60 | Ro60, Y RNA binding protein | 0.00822299 |
| ATL3 | atlastin GTPase 3 | 0.0081911 |
| CLDN12 | claudin 12 | 0.00811885 |
| RSRP1 | arginine/serine-rich protein 1 | 0.00805197 |
| NUCB2 | nucleobindin 2 | 0.00804547 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.328225 |
| PTMA | prothymosin, alpha | -0.268963 |
| TMSB10 | thymosin beta 10 | -0.229541 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.185173 |
| NPSR1 | neuropeptide S receptor 1 | -0.169221 |
| RPS6 | ribosomal protein S6 | -0.110167 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.10908 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.09959 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.098314 |
| GPHN | gephyrin | -0.0826803 |
| ACTG1 | actin gamma 1 | -0.0822825 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0739895 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0670866 |
| TXNIP | thioredoxin interacting protein | -0.0644754 |
| RPL34 | ribosomal protein L34 | -0.063982 |
| RPS23 | ribosomal protein S23 | -0.0605209 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0598479 |
| ANXA2 | annexin A2 | -0.059475 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0587156 |
| RPLP1 | ribosomal protein, large, P1 | -0.0579372 |
| RPL8 | ribosomal protein L8 | -0.0576728 |
| ACTN4 | actinin, alpha 4 | -0.0570355 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0554402 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0549637 |
| TNS4 | tensin 4 | -0.0532476 |
| S100A6 | S100 calcium binding protein A6 | -0.0526083 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0521621 |
| FLNB | filamin B, beta | -0.0520433 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0496092 |
| NDRG1 | N-myc downstream regulated 1 | -0.0495623 |
| ITGA6 | integrin, alpha 6 | -0.0489963 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.048572 |
| PARD3 | par-3 family cell polarity regulator | -0.0473661 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0468418 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0446125 |
| CALB1 | calbindin 1, 28kDa | -0.0435151 |
| SBF2 | SET binding factor 2 | -0.043354 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0429528 |
| ONECUT3 | one cut homeobox 3 | -0.0428977 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0426559 |
| EZR | ezrin | -0.0416969 |
| MYO1E | myosin IE | -0.0412266 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0409844 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0408464 |
| PRSS3 | protease, serine, 3 | -0.0406764 |
| S100A9 | S100 calcium binding protein A9 | -0.0405616 |
| RPS21 | ribosomal protein S21 | -0.0405292 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0403968 |
| RPS8 | ribosomal protein S8 | -0.0403444 |
| S100A10 | S100 calcium binding protein A10 | -0.0403168 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0402639 |
| ABHD2 | abhydrolase domain containing 2 | -0.0386858 |
| RPL32 | ribosomal protein L32 | -0.0380151 |
| MED13L | mediator complex subunit 13-like | -0.0379816 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0375505 |
| HMGA1 | high mobility group AT-hook 1 | -0.0373317 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0370506 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0369846 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0367982 |
| PIGR | polymeric immunoglobulin receptor | -0.036386 |
| GOLGA4 | golgin A4 | -0.0357228 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.03547 |
| PFN1 | profilin 1 | -0.0349145 |
| JMJD1C | jumonji domain containing 1C | -0.0348106 |
| POTEF | POTE ankyrin domain family, member F | -0.0347939 |
| FOXP1 | forkhead box P1 | -0.0341961 |
| RREB1 | ras responsive element binding protein 1 | -0.0341267 |
| VEGFA | vascular endothelial growth factor A | -0.0336443 |
| SETD5 | SET domain containing 5 | -0.0336342 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0330844 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0329484 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0327987 |
| RPS11 | ribosomal protein S11 | -0.0325031 |
| RPL5 | ribosomal protein L5 | -0.0322567 |
| ZNF292 | zinc finger protein 292 | -0.0319644 |
| FOXO1 | forkhead box O1 | -0.0315567 |
| RBM39 | RNA binding motif protein 39 | -0.0310226 |
| CBX3 | chromobox homolog 3 | -0.0305587 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0305426 |
| RNF43 | ring finger protein 43 | -0.0305333 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0305171 |
| NFIA | nuclear factor I/A | -0.0303017 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0302278 |
| KRT8 | keratin 8, type II | -0.0302202 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0301908 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0299575 |
| SMYD3 | SET and MYND domain containing 3 | -0.0299199 |
| MUC17 | mucin 17, cell surface associated | -0.0298647 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0297951 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0297464 |
| MAP4 | microtubule-associated protein 4 | -0.0297255 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.029694 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0296198 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0296189 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0295979 |
| FNBP1L | formin binding protein 1-like | -0.0294468 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0293916 |
| ITGB4 | integrin, beta 4 | -0.0292029 |
| EPCAM | epithelial cell adhesion molecule | -0.0290803 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0290023 |
