| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.275633 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.223186 |
| FTL | ferritin, light polypeptide | 0.109674 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0671421 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0666929 |
| MT2A | metallothionein 2A | 0.0629592 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0538418 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0529777 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0495369 |
| UBC | ubiquitin C | 0.0373124 |
| LDHA | lactate dehydrogenase A | 0.0364166 |
| RPS12 | ribosomal protein S12 | 0.0353328 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0314425 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0311588 |
| SQSTM1 | sequestosome 1 | 0.0306873 |
| RGS4 | regulator of G-protein signaling 4 | 0.0275861 |
| PLEC | plectin | 0.026878 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.024292 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0242563 |
| KRT18 | keratin 18, type I | 0.0240055 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0232068 |
| TXNRD1 | thioredoxin reductase 1 | 0.0228125 |
| EREG | epiregulin | 0.0223769 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0216451 |
| PLK2 | polo-like kinase 2 | 0.0210463 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0206967 |
| RPL12 | ribosomal protein L12 | 0.0204223 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0199416 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0190682 |
| DNER | delta/notch-like EGF repeat containing | 0.0189935 |
| ENO1 | enolase 1, (alpha) | 0.0183313 |
| CCDC200 | coiled-coil domain containing 200 | 0.0182259 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0181318 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0178657 |
| TPM3 | tropomyosin 3 | 0.0178533 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0177236 |
| MT1E | metallothionein 1E | 0.0175231 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0174179 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0172625 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0169696 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0168058 |
| RPS4X | ribosomal protein S4, X-linked | 0.0166514 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.016563 |
| RPL3 | ribosomal protein L3 | 0.0164071 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 0.0161515 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0161056 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0160808 |
| RPS18 | ribosomal protein S18 | 0.0159097 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0158646 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0157838 |
| TMSB4X | thymosin beta 4, X-linked | 0.015706 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0154927 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.015485 |
| HSPA1A | heat shock 70kDa protein 1A | 0.015301 |
| MB21D2 | Mab-21 domain containing 2 | 0.0149081 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0148182 |
| RPL35 | ribosomal protein L35 | 0.0146035 |
| RPS17 | ribosomal protein S17 | 0.0145673 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0145268 |
| RPL11 | ribosomal protein L11 | 0.0144947 |
| B2M | beta-2-microglobulin | 0.01425 |
| SVIL | supervillin | 0.0138622 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0130672 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0129926 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0128424 |
| TPI1 | triosephosphate isomerase 1 | 0.0126292 |
| RACK1 | receptor for activated C kinase 1 | 0.0126172 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0123467 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0122442 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0120961 |
| HPCAL1 | hippocalcin-like 1 | 0.0119541 |
| AEBP2 | AE binding protein 2 | 0.0119089 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0117362 |
| EMP1 | epithelial membrane protein 1 | 0.0117224 |
| JUN | jun proto-oncogene | 0.0116656 |
| PRNP | prion protein | 0.011649 |
| BAG3 | BCL2-associated athanogene 3 | 0.0115758 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0115685 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.011503 |
| UBB | ubiquitin B | 0.0113229 |
| SOD1 | superoxide dismutase 1, soluble | 0.0112937 |
| PRELID2 | PRELI domain containing 2 | 0.0112849 |
| HOMER1 | homer scaffolding protein 1 | 0.0111985 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0110319 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0106765 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0106137 |
| RCAN1 | regulator of calcineurin 1 | 0.0105921 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0105821 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0105065 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0104427 |
| RPL27 | ribosomal protein L27 | 0.0103962 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0102768 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0100328 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.01003 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.010014 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0100033 |
| SF3B6 | splicing factor 3b, subunit 6, 14kDa | 0.00998872 |
| SON | SON DNA binding protein | 0.00998296 |
| LOXL2 | lysyl oxidase-like 2 | 0.00994678 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00993738 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.239322 |
| PTMA | prothymosin, alpha | -0.16534 |
| VIM | vimentin | -0.123335 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0904846 |
| POTEF | POTE ankyrin domain family, member F | -0.0900405 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.072967 |
| TMSB10 | thymosin beta 10 | -0.072705 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0648335 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0563547 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.052729 |
| ACTG1 | actin gamma 1 | -0.0518719 |
| CENPF | centromere protein F, 350/400kDa | -0.0502386 |
| CD44 | CD44 molecule (Indian blood group) | -0.0491776 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0475686 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0457399 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0453836 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0449967 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0388014 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0383815 |
| RPS6 | ribosomal protein S6 | -0.0378383 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0377628 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0357322 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0356818 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.035565 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0350903 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0345222 |
| RTN4 | reticulon 4 | -0.0343645 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.034207 |
| ZNF292 | zinc finger protein 292 | -0.0341331 |
| HMGA1 | high mobility group AT-hook 1 | -0.0341152 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0339185 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0337744 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0336457 |
| TOP1 | topoisomerase (DNA) I | -0.0334234 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0333578 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0330599 |
| FBXO11 | F-box protein 11 | -0.0327884 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0327157 |
| SRPK2 | SRSF protein kinase 2 | -0.0325489 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0324909 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0323804 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0321017 |
| THOC2 | THO complex 2 | -0.0317748 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0316823 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0315795 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0310132 |
| FMNL2 | formin-like 2 | -0.0309772 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0308807 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0308259 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0307891 |
| MKI67 | marker of proliferation Ki-67 | -0.02976 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0296228 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0294818 |
| KPNB1 | karyopherin (importin) beta 1 | -0.029321 |
| WASF2 | WAS protein family, member 2 | -0.0292488 |
| EZR | ezrin | -0.0290124 |
| EHBP1 | EH domain binding protein 1 | -0.0287911 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0285581 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0283639 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.028288 |
| NUP58 | nucleoporin 58 | -0.028244 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0277764 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.027541 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0273407 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0271322 |
| RBM39 | RNA binding motif protein 39 | -0.026942 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0265634 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0265179 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | -0.0263192 |
| BRD4 | bromodomain containing 4 | -0.026205 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0260777 |
| TMEM123 | transmembrane protein 123 | -0.0258752 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0256855 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0255654 |
| EGR1 | early growth response 1 | -0.0255594 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0255285 |
| RAI1 | retinoic acid induced 1 | -0.0253946 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0249675 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0248571 |
| GOLGA4 | golgin A4 | -0.0248509 |
| HLA-B | major histocompatibility complex, class I, B | -0.0246951 |
| JMJD1C | jumonji domain containing 1C | -0.0245979 |
| MAP4 | microtubule-associated protein 4 | -0.0244899 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0244393 |
| FOSL1 | FOS-like antigen 1 | -0.0243338 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0242793 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0242278 |
| SETD5 | SET domain containing 5 | -0.0240998 |
| COL5A2 | collagen, type V, alpha 2 | -0.0240286 |
| SBF2 | SET binding factor 2 | -0.0239662 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0237521 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0237116 |
| XPO1 | exportin 1 | -0.0236612 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0235672 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0232836 |
| WDR45B | WD repeat domain 45B | -0.023242 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0231459 |
| CCNL1 | cyclin L1 | -0.0230157 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0229067 |
| RCOR1 | REST corepressor 1 | -0.0227881 |
