| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD2858_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.210892 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.130817 |
| MCL1 | myeloid cell leukemia 1 | 0.106385 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0999123 |
| SLTM | SAFB-like, transcription modulator | 0.0969554 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0894873 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0879801 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0863135 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0807711 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0766991 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0717523 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0666325 |
| LAMC2 | laminin, gamma 2 | 0.0650503 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0647136 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.062083 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0613575 |
| LDHA | lactate dehydrogenase A | 0.0600738 |
| PLEC | plectin | 0.0569042 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0544785 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0541358 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0531277 |
| MYO1E | myosin IE | 0.0522152 |
| FAM13A | family with sequence similarity 13, member A | 0.0510152 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0509437 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0504985 |
| SMAD3 | SMAD family member 3 | 0.0485607 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.046937 |
| LMO7 | LIM domain 7 | 0.0457689 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0454944 |
| GRAMD1B | GRAM domain containing 1B | 0.0445426 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0442359 |
| MSN | moesin | 0.0436665 |
| PCBP2 | poly(rC) binding protein 2 | 0.0421243 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0418086 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0416696 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0414642 |
| ATP11A | ATPase, class VI, type 11A | 0.0397877 |
| RPL3 | ribosomal protein L3 | 0.0394888 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0390729 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0389473 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0376903 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0374907 |
| ENO1 | enolase 1, (alpha) | 0.037139 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0368696 |
| PDLIM5 | PDZ and LIM domain 5 | 0.036842 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0365458 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0362793 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0357831 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0354532 |
| PKM | pyruvate kinase, muscle | 0.0349502 |
| CES1 | carboxylesterase 1 | 0.0348708 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0342938 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0336727 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0334251 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0325997 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0315315 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0313753 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0313158 |
| PTK2 | protein tyrosine kinase 2 | 0.0308735 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0306737 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0306019 |
| MYOF | myoferlin | 0.0305285 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0302568 |
| ASPH | aspartate beta-hydroxylase | 0.029984 |
| EFNA5 | ephrin-A5 | 0.0299657 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0299598 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.02979 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0296885 |
| AREG | amphiregulin | 0.0295616 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0290463 |
| DTNA | dystrobrevin, alpha | 0.0286461 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0285519 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282751 |
| STC1 | stanniocalcin 1 | 0.0282267 |
| MYO1B | myosin IB | 0.0277049 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0275635 |
| RCOR1 | REST corepressor 1 | 0.0270625 |
| VEGFC | vascular endothelial growth factor C | 0.0268845 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0267898 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0267186 |
| RNF213 | ring finger protein 213 | 0.0265893 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0264135 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0261812 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0260908 |
| SLK | STE20-like kinase | 0.0260888 |
| TPM4 | tropomyosin 4 | 0.0256628 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0255367 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0251726 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0251396 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0248549 |
| SIK3 | SIK family kinase 3 | 0.0247687 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0246501 |
| EGR1 | early growth response 1 | 0.0245948 |
| DIAPH1 | diaphanous-related formin 1 | 0.0244455 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0242991 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0242401 |
| UBC | ubiquitin C | 0.0240738 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0239921 |
| CDCP1 | CUB domain containing protein 1 | 0.0239239 |
| SCEL | sciellin | 0.0238488 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.186585 |
| TMSB10 | thymosin beta 10 | -0.122206 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0965755 |
| RPS3 | ribosomal protein S3 | -0.0884137 |
| MT2A | metallothionein 2A | -0.0853 |
| H1-0 | H1.0 linker histone | -0.0842509 |
| PTMA | prothymosin, alpha | -0.0825644 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0735766 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0674492 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0662827 |
| RPS24 | ribosomal protein S24 | -0.0619844 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0607989 |
| FTL | ferritin, light polypeptide | -0.0605823 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0580355 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.057835 |
| RPL35A | ribosomal protein L35a | -0.057027 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0555667 |
| RPS25 | ribosomal protein S25 | -0.0517086 |
| RPS8 | ribosomal protein S8 | -0.0514442 |
| RPL37A | ribosomal protein L37a | -0.0506021 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0495808 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0479429 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0474052 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0444121 |
| OGA | O-GlcNAcase | -0.0435704 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0431071 |
| CANX | calnexin | -0.0423597 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0422123 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0417583 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0412825 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0409047 |
| LAMB3 | laminin, beta 3 | -0.0397794 |
| ABLIM1 | actin binding LIM protein 1 | -0.0397308 |
| GM2A | GM2 ganglioside activator | -0.0393602 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0393051 |
| PGK1 | phosphoglycerate kinase 1 | -0.0392661 |
| RPL31 | ribosomal protein L31 | -0.0392121 |
| IER3 | immediate early response 3 | -0.0374834 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0369114 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0368964 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0353218 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0342875 |
| HBP1 | HMG-box transcription factor 1 | -0.0342851 |
| RPL34 | ribosomal protein L34 | -0.033731 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0333032 |
| RPS27A | ribosomal protein S27a | -0.0324023 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0323845 |
| RPS29 | ribosomal protein S29 | -0.0319319 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0316752 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0313349 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0312122 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0305312 |
| RPL19 | ribosomal protein L19 | -0.0304303 |
| S100A11 | S100 calcium binding protein A11 | -0.0302466 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0301981 |
| RPLP2 | ribosomal protein, large, P2 | -0.0298185 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0296127 |
| B2M | beta-2-microglobulin | -0.0291313 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0289138 |
| CCNI | cyclin I | -0.0289117 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0285051 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0284501 |
| RPLP1 | ribosomal protein, large, P1 | -0.0283932 |
| TKT | transketolase | -0.0280354 |
| RBM39 | RNA binding motif protein 39 | -0.0279001 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0277572 |
| RPL9 | ribosomal protein L9 | -0.027749 |
| MKI67 | marker of proliferation Ki-67 | -0.0272615 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0271385 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0268012 |
| CSTB | cystatin B (stefin B) | -0.0267534 |
| RPL4 | ribosomal protein L4 | -0.0265058 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.026288 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0262218 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.026169 |
| RNF169 | ring finger protein 169 | -0.0260669 |
| RPS16 | ribosomal protein S16 | -0.0258713 |
| HLA-B | major histocompatibility complex, class I, B | -0.025732 |
| HDLBP | high density lipoprotein binding protein | -0.0255913 |
| RPS21 | ribosomal protein S21 | -0.0255784 |
| RPL26 | ribosomal protein L26 | -0.025453 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0254319 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.02469 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0246743 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0246612 |
| RPL11 | ribosomal protein L11 | -0.0245591 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0244962 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0241964 |
| DENND4A | DENN/MADD domain containing 4A | -0.0241942 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | -0.0241799 |
| ARF1 | ADP-ribosylation factor 1 | -0.0241761 |
| RPL13A | ribosomal protein L13a | -0.0240532 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0239495 |
| XRRA1 | X-ray radiation resistance associated 1 | -0.0238392 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0236683 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0236116 |
| SMIM14 | small integral membrane protein 14 | -0.0233138 |
| SQSTM1 | sequestosome 1 | -0.0232862 |
| FBXO34 | F-box protein 34 | -0.0227349 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0227055 |
