| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.12288 |
| RPL3 | ribosomal protein L3 | 0.0378817 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.035159 |
| TPM3 | tropomyosin 3 | 0.0303092 |
| RPL23 | ribosomal protein L23 | 0.0299801 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0285792 |
| PLEC | plectin | 0.0262444 |
| FTL | ferritin, light polypeptide | 0.0261372 |
| RPS12 | ribosomal protein S12 | 0.0226167 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.021634 |
| HSPA8 | heat shock 70kDa protein 8 | 0.021445 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0205797 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.019806 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0197251 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0194657 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0181168 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0174216 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0172846 |
| PCBP2 | poly(rC) binding protein 2 | 0.0160814 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.015648 |
| RPL11 | ribosomal protein L11 | 0.0155151 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0150671 |
| RPL7 | ribosomal protein L7 | 0.0144921 |
| CCDC200 | coiled-coil domain containing 200 | 0.014277 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0139753 |
| RPS27 | ribosomal protein S27 | 0.0138949 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0138799 |
| TPI1 | triosephosphate isomerase 1 | 0.0138703 |
| B2M | beta-2-microglobulin | 0.0135095 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0133282 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0132766 |
| RPS17 | ribosomal protein S17 | 0.0131234 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0128157 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0127222 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0125963 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0125647 |
| HYOU1 | hypoxia up-regulated 1 | 0.0124746 |
| MT2A | metallothionein 2A | 0.0116908 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0116893 |
| RPL13A | ribosomal protein L13a | 0.0116018 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0111781 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0109396 |
| RPS20 | ribosomal protein S20 | 0.0107451 |
| RPS19 | ribosomal protein S19 | 0.0103965 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0102615 |
| RPS18 | ribosomal protein S18 | 0.0101737 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0101203 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0100957 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.00997331 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.00988683 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.00977437 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.00966324 |
| RPL37A | ribosomal protein L37a | 0.00958512 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.00956361 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.00921483 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00916271 |
| RPL12 | ribosomal protein L12 | 0.00916269 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.00915872 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.0091495 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00906641 |
| RPL10A | ribosomal protein L10a | 0.0089167 |
| UBB | ubiquitin B | 0.00884211 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00880293 |
| RRM2 | ribonucleotide reductase M2 | 0.00879396 |
| YBX1 | Y box binding protein 1 | 0.00867939 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.00867021 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00861894 |
| RPL36 | ribosomal protein L36 | 0.00857519 |
| BRD2 | bromodomain containing 2 | 0.00851635 |
| INTS6 | integrator complex subunit 6 | 0.00851433 |
| WAC | WW domain containing adaptor with coiled-coil | 0.00848217 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00839317 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0083799 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.00837327 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00817735 |
| FLNA | filamin A, alpha | 0.00814767 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.00780779 |
| HSPA1B | heat shock 70kDa protein 1B | 0.00779124 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.007766 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.00774569 |
| RNF145 | ring finger protein 145 | 0.00770721 |
| CUL3 | cullin 3 | 0.00767655 |
| RPS7 | ribosomal protein S7 | 0.00766657 |
| RPL31 | ribosomal protein L31 | 0.00764943 |
| MBTPS1 | membrane-bound transcription factor peptidase, site 1 | 0.0076487 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0076258 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0075201 |
| PUM1 | pumilio RNA-binding family member 1 | 0.00748111 |
| RPL18 | ribosomal protein L18 | 0.00745675 |
| CABIN1 | calcineurin binding protein 1 | 0.00735001 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | 0.00732949 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.00730491 |
| RPS4X | ribosomal protein S4, X-linked | 0.00716653 |
| RCC1 | regulator of chromosome condensation 1 | 0.0070654 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00699633 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.00698338 |
| SERINC1 | serine incorporator 1 | 0.00686597 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.00686282 |
| AHSA1 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) | 0.0068004 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00677691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.297226 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.212087 |
| IGF2 | insulin-like growth factor 2 | -0.116189 |
| ACTG1 | actin gamma 1 | -0.115929 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.110943 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.105999 |
| TMSB10 | thymosin beta 10 | -0.101424 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0913623 |
| GRAMD1B | GRAM domain containing 1B | -0.0864045 |
| VIM | vimentin | -0.0777626 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0681236 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0643008 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0562263 |
| CMIP | c-Maf inducing protein | -0.0516432 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0511201 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0495783 |
| STC1 | stanniocalcin 1 | -0.0485451 |
| EGR1 | early growth response 1 | -0.0477 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.044865 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0431803 |
| BICC1 | BicC family RNA binding protein 1 | -0.0431801 |
| PYGL | phosphorylase, glycogen, liver | -0.0431289 |
| IER3 | immediate early response 3 | -0.0418505 |
| PTMA | prothymosin, alpha | -0.0413469 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.03959 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0389533 |
| OSMR | oncostatin M receptor | -0.0380524 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0379395 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0376509 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0375524 |
| TXNRD1 | thioredoxin reductase 1 | -0.037508 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0374845 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0369511 |
| NEGR1 | neuronal growth regulator 1 | -0.0366765 |
| DST | dystonin | -0.0363404 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0361706 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0359911 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0359421 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0352106 |
| TPM4 | tropomyosin 4 | -0.0332156 |
| POTEF | POTE ankyrin domain family, member F | -0.0326124 |
| FLNB | filamin B, beta | -0.0325856 |
| UTRN | utrophin | -0.032447 |
| DOCK5 | dedicator of cytokinesis 5 | -0.032081 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0317166 |
| AK1 | adenylate kinase 1 | -0.0314313 |
| PFN1 | profilin 1 | -0.030995 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0309875 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0301662 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0300329 |
| EFNA5 | ephrin-A5 | -0.0298198 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0289979 |
| S100A6 | S100 calcium binding protein A6 | -0.0289294 |
| SVIL | supervillin | -0.0289253 |
| RAD51B | RAD51 paralog B | -0.0284919 |
| EGFR | epidermal growth factor receptor | -0.0283649 |
| SRGN | serglycin | -0.0282836 |
| HMGA1 | high mobility group AT-hook 1 | -0.0276347 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0269973 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0268901 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0268411 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0268351 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0266945 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0263256 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0261032 |
| NRG1 | neuregulin 1 | -0.0260914 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0257078 |
| CFDP1 | craniofacial development protein 1 | -0.0249819 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0249194 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0248442 |
| GLIS3 | GLIS family zinc finger 3 | -0.0242552 |
| ASPH | aspartate beta-hydroxylase | -0.0239673 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0236269 |
| HDAC9 | histone deacetylase 9 | -0.0235123 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0234936 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0234932 |
| S100A10 | S100 calcium binding protein A10 | -0.0234058 |
| FMNL2 | formin-like 2 | -0.0233978 |
| ZFHX3 | zinc finger homeobox 3 | -0.0233213 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0232136 |
| EHBP1 | EH domain binding protein 1 | -0.0229758 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.022971 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0229528 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0229076 |
| NAV3 | neuron navigator 3 | -0.0228274 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0228265 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0227474 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0223184 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0222719 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0221931 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0221369 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0220801 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0219242 |
| MYL12B | myosin, light chain 12B, regulatory | -0.021645 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0215748 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0212046 |
| HLA-B | major histocompatibility complex, class I, B | -0.0211087 |
| NEBL | nebulette | -0.0210136 |
| MAP1B | microtubule-associated protein 1B | -0.0206631 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0204387 |
