| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.17364 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.146184 |
| KRT17 | keratin 17, type I | 0.119361 |
| TMSB10 | thymosin beta 10 | 0.101457 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0905264 |
| PKM | pyruvate kinase, muscle | 0.0892634 |
| RPS12 | ribosomal protein S12 | 0.078587 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0762401 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0755524 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0732061 |
| CDH13 | cadherin 13 | 0.0707457 |
| KYNU | kynureninase | 0.0671096 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0656281 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0652195 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0633494 |
| TOP1 | topoisomerase (DNA) I | 0.0623635 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0607107 |
| RPL35A | ribosomal protein L35a | 0.060455 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0593852 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0567134 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0561904 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0557673 |
| PLEC | plectin | 0.0544424 |
| PDE10A | phosphodiesterase 10A | 0.053481 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0524944 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0509095 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.05061 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0488734 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0454245 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0450263 |
| ENO1 | enolase 1, (alpha) | 0.0429557 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0429349 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0422199 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0417777 |
| MCL1 | myeloid cell leukemia 1 | 0.0406148 |
| SLK | STE20-like kinase | 0.0406124 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0403462 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0400968 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0395974 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0392412 |
| PLK2 | polo-like kinase 2 | 0.038878 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.038744 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0378258 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0374017 |
| SSH2 | slingshot protein phosphatase 2 | 0.03733 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0372637 |
| HM13 | histocompatibility (minor) 13 | 0.0371858 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0370922 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0366714 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0364621 |
| TSC22D2 | TSC22 domain family, member 2 | 0.036067 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0357333 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0352025 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0336928 |
| KRT18 | keratin 18, type I | 0.0333397 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0327832 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0326491 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0325212 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0324041 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0321483 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0321326 |
| RPS6 | ribosomal protein S6 | 0.0320376 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0314764 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0314244 |
| FRYL | FRY-like | 0.0313316 |
| RACK1 | receptor for activated C kinase 1 | 0.0311929 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0308475 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0308261 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0308244 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0305676 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0302295 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0299918 |
| ITSN2 | intersectin 2 | 0.0293146 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0291702 |
| SAFB2 | scaffold attachment factor B2 | 0.0290955 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0289732 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0288826 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0288265 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0282123 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0275654 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0273403 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0273242 |
| RPLP0 | ribosomal protein, large, P0 | 0.0272424 |
| RSL24D1 | ribosomal L24 domain containing 1 | 0.0270838 |
| IRS2 | insulin receptor substrate 2 | 0.0268422 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.026829 |
| SBF2 | SET binding factor 2 | 0.0267525 |
| STRBP | spermatid perinuclear RNA binding protein | 0.0264676 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0263237 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0255095 |
| RPL13A | ribosomal protein L13a | 0.025407 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0252136 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0251191 |
| PCBP2 | poly(rC) binding protein 2 | 0.0250807 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0250383 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0243303 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0242858 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.024235 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0242301 |
| TKT | transketolase | 0.0239922 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.119337 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0933061 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0765313 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0609523 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0604321 |
| RIOK3 | RIO kinase 3 | -0.0576632 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.056126 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0546215 |
| NDRG1 | N-myc downstream regulated 1 | -0.0542935 |
| FN1 | fibronectin 1 | -0.0501127 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0497562 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0485222 |
| RPL19 | ribosomal protein L19 | -0.0479645 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0477855 |
| DST | dystonin | -0.0477599 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0477283 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.046458 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0433513 |
| ANXA2 | annexin A2 | -0.043227 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0432123 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.042489 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.041999 |
| RBM25 | RNA binding motif protein 25 | -0.0417411 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0415531 |
| CDYL | chromodomain protein, Y-like | -0.0409563 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0409378 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0408783 |
| TMEM165 | transmembrane protein 165 | -0.040567 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0403465 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0402136 |
| FNBP1L | formin binding protein 1-like | -0.0401627 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0401332 |
| ZNF638 | zinc finger protein 638 | -0.0401234 |
| NUP98 | nucleoporin 98kDa | -0.0393725 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0390837 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.038992 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0389092 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0384714 |
| ATOSA | atos homolog A | -0.0382205 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0381551 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.03788 |
| TAOK3 | TAO kinase 3 | -0.0371783 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0369777 |
| FAM13A | family with sequence similarity 13, member A | -0.0368489 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0364831 |
| IGF2 | insulin-like growth factor 2 | -0.0364381 |
| FDPS | farnesyl diphosphate synthase | -0.0363299 |
| DENND1A | DENN/MADD domain containing 1A | -0.0362857 |
| TLK1 | tousled-like kinase 1 | -0.0361121 |
| DSG2 | desmoglein 2 | -0.0356966 |
| EGR1 | early growth response 1 | -0.0356592 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0353788 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0352775 |
| POTEF | POTE ankyrin domain family, member F | -0.0350983 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0350871 |
| WASF2 | WAS protein family, member 2 | -0.0350653 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0342832 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0341772 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0341685 |
| TNPO1 | transportin 1 | -0.0341485 |
| MMP1 | matrix metallopeptidase 1 | -0.0340687 |
| ANXA1 | annexin A1 | -0.0339477 |
| RSF1 | remodeling and spacing factor 1 | -0.033533 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0332769 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0325391 |
| CMIP | c-Maf inducing protein | -0.0322611 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0322595 |
| PTGES2 | prostaglandin E synthase 2 | -0.0316837 |
| FTL | ferritin, light polypeptide | -0.0314343 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0313526 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0312425 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0312096 |
| CD2AP | CD2-associated protein | -0.0308322 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0307408 |
| PGK1 | phosphoglycerate kinase 1 | -0.0304076 |
| HLA-B | major histocompatibility complex, class I, B | -0.0302049 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0301704 |
| FOXP1 | forkhead box P1 | -0.0298613 |
| FMN1 | formin 1 | -0.0296675 |
| MUC16 | mucin 16, cell surface associated | -0.0294871 |
| TMEM123 | transmembrane protein 123 | -0.0294752 |
| BBX | bobby sox homolog (Drosophila) | -0.0292824 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0291611 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.028884 |
| ANKRD12 | ankyrin repeat domain 12 | -0.028615 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0281128 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0278808 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0278253 |
| SMYD3 | SET and MYND domain containing 3 | -0.0277371 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0276143 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | -0.0275133 |
| HMGA2 | high mobility group AT-hook 2 | -0.0274856 |
| XPO1 | exportin 1 | -0.0273294 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0272689 |
| RLF | rearranged L-myc fusion | -0.027191 |
| SQSTM1 | sequestosome 1 | -0.0271184 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0269326 |
| S100A9 | S100 calcium binding protein A9 | -0.0267698 |
| ZNF644 | zinc finger protein 644 | -0.0265766 |
| PRKCA | protein kinase C, alpha | -0.0265765 |
