| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.430621 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.321557 |
| MCL1 | myeloid cell leukemia 1 | 0.124507 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.112885 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0987742 |
| GRAMD1B | GRAM domain containing 1B | 0.0852215 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0813362 |
| CCDC200 | coiled-coil domain containing 200 | 0.070933 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0641921 |
| TPI1 | triosephosphate isomerase 1 | 0.0634253 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0566706 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0566252 |
| RPS4X | ribosomal protein S4, X-linked | 0.054209 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0528961 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0516116 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.04887 |
| OSMR | oncostatin M receptor | 0.0480811 |
| WWOX | WW domain containing oxidoreductase | 0.0473948 |
| VCL | vinculin | 0.0468649 |
| TPM3 | tropomyosin 3 | 0.0449045 |
| LDHA | lactate dehydrogenase A | 0.0439473 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0437248 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0432076 |
| YBX3 | Y box binding protein 3 | 0.0424319 |
| RPL23 | ribosomal protein L23 | 0.0424304 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0414253 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0409537 |
| PDE10A | phosphodiesterase 10A | 0.0404146 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0403968 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0403709 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0400621 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0393152 |
| PLEC | plectin | 0.0383601 |
| AHNAK | AHNAK nucleoprotein | 0.0377763 |
| ACTG1 | actin gamma 1 | 0.0375205 |
| TPM4 | tropomyosin 4 | 0.0375016 |
| FMNL2 | formin-like 2 | 0.0373717 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0371819 |
| HMGA2 | high mobility group AT-hook 2 | 0.0371734 |
| RPL3 | ribosomal protein L3 | 0.0367768 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0353081 |
| UBC | ubiquitin C | 0.0351072 |
| INTS6 | integrator complex subunit 6 | 0.0344751 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0344095 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0342398 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0338804 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0330907 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0329925 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0329041 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0317064 |
| VCP | valosin containing protein | 0.0315446 |
| HOMER1 | homer scaffolding protein 1 | 0.0308598 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0304073 |
| ATXN1 | ataxin 1 | 0.0304034 |
| DSPP | dentin sialophosphoprotein | 0.0300885 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0296958 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0296592 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0295871 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0283646 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0282007 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0278404 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0278362 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0277602 |
| KRT18 | keratin 18, type I | 0.027755 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0276995 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0275603 |
| ENO1 | enolase 1, (alpha) | 0.0273601 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0272365 |
| VMP1 | vacuole membrane protein 1 | 0.0271049 |
| SMAD3 | SMAD family member 3 | 0.0266579 |
| PYGL | phosphorylase, glycogen, liver | 0.0264531 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0260602 |
| LOXL2 | lysyl oxidase-like 2 | 0.0260158 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0259595 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0255079 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0252779 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0249597 |
| SVIL | supervillin | 0.024899 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0244877 |
| PRKCE | protein kinase C, epsilon | 0.0243792 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0242217 |
| YAP1 | Yes-associated protein 1 | 0.0241028 |
| ACTN1 | actinin, alpha 1 | 0.0240059 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0239396 |
| RRM2 | ribonucleotide reductase M2 | 0.023797 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0237094 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.023512 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0234718 |
| TLN1 | talin 1 | 0.0233357 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.023229 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.023032 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0229604 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0229497 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0227659 |
| S100A10 | S100 calcium binding protein A10 | 0.0224791 |
| SETX | senataxin | 0.0224197 |
| JUN | jun proto-oncogene | 0.0218321 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.021644 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0215562 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0214552 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.12723 |
| PHIP | pleckstrin homology domain interacting protein | -0.065462 |
| RTN4 | reticulon 4 | -0.0545547 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0541609 |
| RPS3 | ribosomal protein S3 | -0.0524493 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0518111 |
| RPL37A | ribosomal protein L37a | -0.0497953 |
| PTMA | prothymosin, alpha | -0.0454718 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0445761 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0411682 |
| BBX | bobby sox homolog (Drosophila) | -0.0405153 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0394803 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0346504 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0344503 |
| TXNRD1 | thioredoxin reductase 1 | -0.0342742 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0339275 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0334106 |
| OGA | O-GlcNAcase | -0.0326097 |
| MKI67 | marker of proliferation Ki-67 | -0.0322173 |
| PCNX1 | pecanex 1 | -0.0320783 |
| ZNF292 | zinc finger protein 292 | -0.0318494 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0314922 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0313313 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0311146 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0308892 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0306451 |
| PFN1 | profilin 1 | -0.0302277 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0302035 |
| RBM25 | RNA binding motif protein 25 | -0.030038 |
| GPHN | gephyrin | -0.0297944 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0297522 |
| RPL19 | ribosomal protein L19 | -0.0296503 |
| SEPTIN7 | septin 7 | -0.0292321 |
| XPO1 | exportin 1 | -0.0288005 |
| RBM39 | RNA binding motif protein 39 | -0.0287712 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0285922 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0279315 |
| GOLGA4 | golgin A4 | -0.0277846 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0277534 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0277217 |
| TMSB10 | thymosin beta 10 | -0.0273828 |
| SBF2 | SET binding factor 2 | -0.0272504 |
| IGF2 | insulin-like growth factor 2 | -0.0272332 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0269549 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0267393 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0264927 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0253038 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0252438 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0248949 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0246471 |
| RNF38 | ring finger protein 38 | -0.0245031 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0242886 |
| RPL9 | ribosomal protein L9 | -0.024108 |
| TMEM165 | transmembrane protein 165 | -0.0240873 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0239341 |
| EGR1 | early growth response 1 | -0.0236886 |
| CEP95 | centrosomal protein 95kDa | -0.0232298 |
| RPS2 | ribosomal protein S2 | -0.0232093 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0231676 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0231299 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0229953 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0228319 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0226104 |
| SRPK1 | SRSF protein kinase 1 | -0.0225434 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0225045 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0223928 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0223638 |
| FBXO34 | F-box protein 34 | -0.0223578 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0222077 |
| RASA2 | RAS p21 protein activator 2 | -0.0221127 |
| RNF145 | ring finger protein 145 | -0.022083 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0220006 |
| TLK1 | tousled-like kinase 1 | -0.0218404 |
| RPL7A | ribosomal protein L7a | -0.0218351 |
| H1-0 | H1.0 linker histone | -0.0216568 |
| SRPK2 | SRSF protein kinase 2 | -0.0214425 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0212755 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0212024 |
| RSF1 | remodeling and spacing factor 1 | -0.021184 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0211268 |
| CCNL1 | cyclin L1 | -0.0209584 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0209372 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0208285 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0207593 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0207504 |
| TNPO3 | transportin 3 | -0.0201605 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0201222 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | -0.0200904 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0198396 |
| RPL38 | ribosomal protein L38 | -0.0198086 |
| EPN2 | epsin 2 | -0.0197886 |
| ZFR | zinc finger RNA binding protein | -0.0196818 |
| WASF2 | WAS protein family, member 2 | -0.0196775 |
| RPS10 | ribosomal protein S10 | -0.0196639 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0196627 |
| COG5 | component of oligomeric golgi complex 5 | -0.0196282 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0194526 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0194272 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0193846 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0193316 |
