| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.131144 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.120275 |
| PLEC | plectin | 0.119928 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0998502 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0901463 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.085835 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0674646 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0633109 |
| NAV2 | neuron navigator 2 | 0.0621779 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0589786 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0517108 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0514633 |
| LDHA | lactate dehydrogenase A | 0.050631 |
| RPL3 | ribosomal protein L3 | 0.046458 |
| MSN | moesin | 0.0451787 |
| DSPP | dentin sialophosphoprotein | 0.0430078 |
| SMAD3 | SMAD family member 3 | 0.0421067 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.041621 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0394912 |
| OCLN | occludin | 0.0389555 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0389247 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0381052 |
| EFNA5 | ephrin-A5 | 0.0380709 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0377225 |
| MCL1 | myeloid cell leukemia 1 | 0.0374584 |
| PALLD | palladin, cytoskeletal associated protein | 0.0366537 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0343943 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.0343704 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.034268 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0335062 |
| DTNA | dystrobrevin, alpha | 0.0333129 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0320322 |
| SGMS2 | sphingomyelin synthase 2 | 0.0318032 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0317708 |
| ATXN1 | ataxin 1 | 0.0315048 |
| INTS6 | integrator complex subunit 6 | 0.0311883 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0310089 |
| MYO5B | myosin VB | 0.0305445 |
| ARRDC3 | arrestin domain containing 3 | 0.0303386 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0300744 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0296048 |
| TJP1 | tight junction protein 1 | 0.0285761 |
| MAP1B | microtubule-associated protein 1B | 0.0281905 |
| FLNA | filamin A, alpha | 0.0281407 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0280508 |
| SVIL | supervillin | 0.0279373 |
| FHIT | fragile histidine triad | 0.0278895 |
| VGLL3 | vestigial-like family member 3 | 0.027745 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0276757 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0275746 |
| PDLIM5 | PDZ and LIM domain 5 | 0.027565 |
| TPM3 | tropomyosin 3 | 0.0267137 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0262048 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0261316 |
| PCBP2 | poly(rC) binding protein 2 | 0.0261261 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0261221 |
| BRD2 | bromodomain containing 2 | 0.026056 |
| KIAA1217 | KIAA1217 | 0.0259112 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0256174 |
| EGFR | epidermal growth factor receptor | 0.0251431 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0251237 |
| POTEF | POTE ankyrin domain family, member F | 0.0248649 |
| VMP1 | vacuole membrane protein 1 | 0.0246339 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0243189 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0240398 |
| RHOA | ras homolog family member A | 0.0238433 |
| SEPTIN9 | septin 9 | 0.0229176 |
| VCL | vinculin | 0.0227871 |
| PTK2 | protein tyrosine kinase 2 | 0.022502 |
| DST | dystonin | 0.0221645 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0215923 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0212441 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0211275 |
| PRKCA | protein kinase C, alpha | 0.0211017 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0210734 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0209135 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0208904 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0208245 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0208123 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0207412 |
| NTN4 | netrin 4 | 0.0206592 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0206472 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0205566 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0203771 |
| SMYD3 | SET and MYND domain containing 3 | 0.0199837 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0199297 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0197633 |
| DIAPH1 | diaphanous-related formin 1 | 0.0197416 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0196245 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0195444 |
| MX1 | MX dynamin-like GTPase 1 | 0.0193611 |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides | 0.0190906 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0190805 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0189757 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0186554 |
| RAD51B | RAD51 paralog B | 0.0185206 |
| FNIP1 | folliculin interacting protein 1 | 0.0184865 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0184689 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0184572 |
| ENO1 | enolase 1, (alpha) | 0.0180908 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.243041 |
| ACTG1 | actin gamma 1 | -0.168032 |
| FTL | ferritin, light polypeptide | -0.141798 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.136387 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.130215 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.12079 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.108603 |
| TMSB10 | thymosin beta 10 | -0.108043 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0983405 |
| LAMB3 | laminin, beta 3 | -0.0919281 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0784028 |
| CD2AP | CD2-associated protein | -0.0758815 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0751918 |
| NDRG1 | N-myc downstream regulated 1 | -0.0745522 |
| TMSB4X | thymosin beta 4, X-linked | -0.0707636 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0662519 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0641453 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0625372 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0619027 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0595246 |
| RBM25 | RNA binding motif protein 25 | -0.0562617 |
| GNAS | GNAS complex locus | -0.0544322 |
| S100A6 | S100 calcium binding protein A6 | -0.0530335 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0530157 |
| OGA | O-GlcNAcase | -0.0527933 |
| CSTB | cystatin B (stefin B) | -0.0524287 |
| HLA-B | major histocompatibility complex, class I, B | -0.0521484 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0519132 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0511819 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0503674 |
| RPL35A | ribosomal protein L35a | -0.0500421 |
| TOP1 | topoisomerase (DNA) I | -0.0495382 |
| GOLGA4 | golgin A4 | -0.0494585 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0482502 |
| PGK1 | phosphoglycerate kinase 1 | -0.0477973 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0477128 |
| RPL34 | ribosomal protein L34 | -0.0475255 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0464265 |
| TPM4 | tropomyosin 4 | -0.0456934 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0455198 |
| TMEM263 | transmembrane protein 263 | -0.0451772 |
| RBM39 | RNA binding motif protein 39 | -0.0446173 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0440379 |
| EPCAM | epithelial cell adhesion molecule | -0.0437087 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0429234 |
| CAVIN1 | caveolae associated protein 1 | -0.0427605 |
| S100A10 | S100 calcium binding protein A10 | -0.0421524 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0417227 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0409356 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0408984 |
| LMO7 | LIM domain 7 | -0.0407744 |
| FAM162A | family with sequence similarity 162, member A | -0.0402942 |
| FN1 | fibronectin 1 | -0.0401014 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0382552 |
| ANXA2 | annexin A2 | -0.0381891 |
| TPR | translocated promoter region, nuclear basket protein | -0.0379881 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0377757 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0375426 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0374553 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.037089 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0367691 |
| RPS29 | ribosomal protein S29 | -0.0367505 |
| CANX | calnexin | -0.0364652 |
| H3-3B | H3.3 histone B | -0.0363391 |
| FBXO32 | F-box protein 32 | -0.0358657 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0350349 |
| RNF145 | ring finger protein 145 | -0.0350313 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0346027 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0342407 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0341273 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0332868 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0331963 |
| HLA-E | major histocompatibility complex, class I, E | -0.0331128 |
| TMEM123 | transmembrane protein 123 | -0.0330652 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0330081 |
| HLA-A | major histocompatibility complex, class I, A | -0.032568 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.032534 |
| RRBP1 | ribosome binding protein 1 | -0.0324197 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0319728 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0309041 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0308425 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0308413 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0302168 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0302085 |
| USP3 | ubiquitin specific peptidase 3 | -0.0298844 |
| MYO6 | myosin VI | -0.0297692 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0295135 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0292774 |
| RIOK3 | RIO kinase 3 | -0.0290549 |
| RLF | rearranged L-myc fusion | -0.0288532 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0288322 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0288187 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.02849 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.028299 |
| YY1 | YY1 transcription factor | -0.0281848 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0281031 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0280629 |
| TFG | TRK-fused gene | -0.0278219 |
| SQSTM1 | sequestosome 1 | -0.0276756 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0274754 |
