| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.258223 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.175675 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.131582 |
| COL5A2 | collagen, type V, alpha 2 | 0.106796 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0965601 |
| LDHA | lactate dehydrogenase A | 0.0939118 |
| UBC | ubiquitin C | 0.091623 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0853521 |
| MYOF | myoferlin | 0.0844519 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0766449 |
| RPS4X | ribosomal protein S4, X-linked | 0.0748209 |
| TXNRD1 | thioredoxin reductase 1 | 0.0702103 |
| RPL3 | ribosomal protein L3 | 0.0679672 |
| LOC112694756 | uncharaterized LOC112694756 | 0.062179 |
| ENO1 | enolase 1, (alpha) | 0.0618571 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0555354 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0551891 |
| GDA | guanine deaminase | 0.0547293 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0546277 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0521128 |
| KYNU | kynureninase | 0.0499268 |
| RPS6 | ribosomal protein S6 | 0.0481176 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0481068 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0474494 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0471486 |
| CLU | clusterin | 0.0469403 |
| CD109 | CD109 molecule | 0.0464052 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.046277 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0462146 |
| RAB3B | RAB3B, member RAS oncogene family | 0.045359 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0448772 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0432275 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0428424 |
| EZR | ezrin | 0.0418545 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0395696 |
| TPI1 | triosephosphate isomerase 1 | 0.0394014 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0393871 |
| RPS23 | ribosomal protein S23 | 0.0382368 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0377939 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0373161 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0371223 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.035497 |
| PCBP2 | poly(rC) binding protein 2 | 0.0347711 |
| ASPH | aspartate beta-hydroxylase | 0.0345948 |
| TPM3 | tropomyosin 3 | 0.0341993 |
| SFTPA2 | surfactant protein A2 | 0.0341752 |
| SET | SET nuclear proto-oncogene | 0.0329494 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.032927 |
| RGS2 | regulator of G-protein signaling 2 | 0.0323815 |
| KRT19 | keratin 19, type I | 0.0320196 |
| YBX3 | Y box binding protein 3 | 0.0319099 |
| GRAMD1B | GRAM domain containing 1B | 0.0313891 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0306431 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0306268 |
| MAP7 | microtubule-associated protein 7 | 0.0305571 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0301397 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0299885 |
| ASTN2 | astrotactin 2 | 0.0297758 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0297622 |
| MSN | moesin | 0.0296878 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0296697 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0296465 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0294216 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0293886 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0291987 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0287206 |
| RACK1 | receptor for activated C kinase 1 | 0.0286868 |
| RPLP0 | ribosomal protein, large, P0 | 0.0286162 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0282574 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0279261 |
| S100A10 | S100 calcium binding protein A10 | 0.0277774 |
| FTL | ferritin, light polypeptide | 0.0266784 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0262345 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0261751 |
| TBXT | T-box transcription factor T | 0.0257967 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0257878 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0251781 |
| RPL18 | ribosomal protein L18 | 0.0251209 |
| RPL39 | ribosomal protein L39 | 0.0250751 |
| TUSC3 | tumor suppressor candidate 3 | 0.0248935 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0245895 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.024532 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0244326 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0243638 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0243433 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0242826 |
| RPS27 | ribosomal protein S27 | 0.0240624 |
| RPL8 | ribosomal protein L8 | 0.0239361 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0235983 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.0231156 |
| SCARA5 | scavenger receptor class A, member 5 | 0.0230083 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0229737 |
| MATR3 | matrin 3 | 0.0227942 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0224573 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0223085 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0220445 |
| PLK2 | polo-like kinase 2 | 0.0220098 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0217256 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0215402 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0213183 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.122588 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.119495 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.114585 |
| EFNA5 | ephrin-A5 | -0.108776 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.096468 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0763448 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0756979 |
| PTMA | prothymosin, alpha | -0.0741586 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0643887 |
| PCBP3 | poly(rC) binding protein 3 | -0.064075 |
| RPL37A | ribosomal protein L37a | -0.0638077 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0600598 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.057354 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0572234 |
| RPL31 | ribosomal protein L31 | -0.0567597 |
| CDH13 | cadherin 13 | -0.056211 |
| RPS24 | ribosomal protein S24 | -0.0486174 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0481003 |
| TMSB10 | thymosin beta 10 | -0.0453181 |
| STC1 | stanniocalcin 1 | -0.0452745 |
| AUTS2 | autism susceptibility candidate 2 | -0.0399137 |
| NDRG1 | N-myc downstream regulated 1 | -0.0387817 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0382035 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0380774 |
| VCL | vinculin | -0.0372762 |
| DENND1A | DENN/MADD domain containing 1A | -0.0361491 |
| VIM | vimentin | -0.0359879 |
| PRELID2 | PRELI domain containing 2 | -0.0346709 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0342112 |
| NCKAP5 | NCK-associated protein 5 | -0.0331804 |
| RPL13A | ribosomal protein L13a | -0.0329983 |
| MT2A | metallothionein 2A | -0.0323994 |
| RPS25 | ribosomal protein S25 | -0.0320873 |
| RPS12 | ribosomal protein S12 | -0.0307853 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0306463 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0302348 |
| RPL7A | ribosomal protein L7a | -0.0302197 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0299804 |
| RBM39 | RNA binding motif protein 39 | -0.0297795 |
| EGR1 | early growth response 1 | -0.0294667 |
| OGA | O-GlcNAcase | -0.0290222 |
| HLA-B | major histocompatibility complex, class I, B | -0.028952 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0286459 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0286267 |
| RPLP2 | ribosomal protein, large, P2 | -0.0285534 |
| NF1 | neurofibromin 1 | -0.0280109 |
| RPL5 | ribosomal protein L5 | -0.0271178 |
| RPS29 | ribosomal protein S29 | -0.0267141 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0266233 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0261975 |
| PDE10A | phosphodiesterase 10A | -0.026087 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0260411 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0257764 |
| IER3 | immediate early response 3 | -0.0253874 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0249556 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0249152 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0242972 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0240869 |
| RPS13 | ribosomal protein S13 | -0.0239931 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0238277 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0236324 |
| RPS16 | ribosomal protein S16 | -0.0235867 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0234383 |
| GPC6 | glypican 6 | -0.0232651 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0232029 |
| RIGI | RNA sensor RIG-I | -0.0229587 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0229308 |
| RPL9 | ribosomal protein L9 | -0.022798 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0225224 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0220912 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.021608 |
| HM13 | histocompatibility (minor) 13 | -0.0214134 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0212787 |
| IGF1R | insulin-like growth factor 1 receptor | -0.021122 |
| RPL38 | ribosomal protein L38 | -0.0209553 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0207955 |
| SPAG9 | sperm associated antigen 9 | -0.0207432 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0206302 |
| FLNB | filamin B, beta | -0.0205731 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0203951 |
| FUS | FUS RNA binding protein | -0.0200441 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0200269 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0198074 |
| DENND4A | DENN/MADD domain containing 4A | -0.0197993 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0196857 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0196651 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0193664 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0193278 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.0193046 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0189186 |
| CCDC6 | coiled-coil domain containing 6 | -0.0187929 |
| ATP5MC2 | ATP synthase membrane subunit c locus 2 | -0.018337 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0183273 |
| RPL37 | ribosomal protein L37 | -0.0181478 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.017968 |
| AEBP2 | AE binding protein 2 | -0.0179662 |
| RTN1 | reticulon 1 | -0.0179282 |
| CALR | calreticulin | -0.0179058 |
| EXOC4 | exocyst complex component 4 | -0.0178736 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0178654 |
