AZD2858_NCI-H596 Gene Set
Genes
49 genes differentially expressed following the AZD2858_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
RBPJ
|
recombination signal binding protein for immunoglobulin kappa J region
|
0.212785
|
|
AKAP12
|
A kinase (PRKA) anchor protein 12
|
0.185471
|
|
TRIO
|
trio Rho guanine nucleotide exchange factor
|
0.166452
|
|
HIVEP3
|
human immunodeficiency virus type I enhancer binding protein 3
|
0.157173
|
|
SLC2A13
|
solute carrier family 2 (facilitated glucose transporter), member 13
|
0.127359
|
|
TRA2A
|
transformer 2 alpha homolog (Drosophila)
|
0.10149
|
|
NPAS2
|
neuronal PAS domain protein 2
|
0.0981026
|
|
KMT2C
|
lysine (K)-specific methyltransferase 2C
|
0.0876115
|
|
PSD3
|
pleckstrin and Sec7 domain containing 3
|
0.0862602
|
|
RPLP0
|
ribosomal protein, large, P0
|
0.0835867
|
|
RBM39
|
RNA binding motif protein 39
|
0.0791778
|
|
GOLGA4
|
golgin A4
|
0.074909
|
|
GNAS
|
GNAS complex locus
|
0.0698185
|
|
RPL12
|
ribosomal protein L12
|
0.0605862
|
|
FN1
|
fibronectin 1
|
0.0473234
|
|
KMT2E
|
lysine (K)-specific methyltransferase 2E
|
0.04605
|
|
PDE3A
|
phosphodiesterase 3A, cGMP-inhibited
|
0.0459963
|
|
B2M
|
beta-2-microglobulin
|
0.0459613
|
|
SON
|
SON DNA binding protein
|
0.0357895
|
|
ZSWIM6
|
zinc finger, SWIM-type containing 6
|
0.0348724
|
|
ZC3HAV1
|
zinc finger CCCH-type, antiviral 1
|
0.0335083
|
|
RPL11
|
ribosomal protein L11
|
0.028419
|
|
PTK2
|
protein tyrosine kinase 2
|
0.0233462
|
|
GPC6
|
glypican 6
|
0.0222387
|
|
RPL7A
|
ribosomal protein L7a
|
0.017981
|
|
NUCKS1
|
nuclear casein kinase and cyclin-dependent kinase substrate 1
|
0.00736636
|
|
LSAMP
|
limbic system-associated membrane protein
|
0.00718779
|
|
PTMA
|
prothymosin, alpha
|
0.00133169
|
|
PDLIM5
|
PDZ and LIM domain 5
|
0.00125264
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
UBC
|
ubiquitin C
|
-0.250784
|
|
NKD1
|
naked cuticle homolog 1 (Drosophila)
|
-0.239757
|
|
ROBO2
|
roundabout, axon guidance receptor, homolog 2 (Drosophila)
|
-0.239298
|
|
SNX9
|
sorting nexin 9
|
-0.141993
|
|
PDE4D
|
phosphodiesterase 4D, cAMP-specific
|
-0.141273
|
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
-0.132698
|
|
VIM
|
vimentin
|
-0.125509
|
|
RPS16
|
ribosomal protein S16
|
-0.114708
|
|
PLCB1
|
phospholipase C, beta 1 (phosphoinositide-specific)
|
-0.0963303
|
|
ASH1L
|
ash1 (absent, small, or homeotic)-like (Drosophila)
|
-0.0843775
|
|
MT2A
|
metallothionein 2A
|
-0.080641
|
|
PARD3
|
par-3 family cell polarity regulator
|
-0.0662539
|
|
DLG1
|
discs, large homolog 1 (Drosophila)
|
-0.064537
|
|
RPLP1
|
ribosomal protein, large, P1
|
-0.0637687
|
|
H3-3B
|
H3.3 histone B
|
-0.0622724
|
|
EGFR
|
epidermal growth factor receptor
|
-0.0581371
|
|
DNAJC5
|
DnaJ (Hsp40) homolog, subfamily C, member 5
|
-0.0440124
|
|
RPS27A
|
ribosomal protein S27a
|
-0.0430215
|
|
MACF1
|
microtubule-actin crosslinking factor 1
|
-0.0272343
|
|
FNDC3B
|
fibronectin type III domain containing 3B
|
-0.0117357
|
