| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS8 | ribosomal protein S8 | 0.0970873 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0932249 |
| LDHA | lactate dehydrogenase A | 0.08786 |
| PGK1 | phosphoglycerate kinase 1 | 0.0803125 |
| COL5A2 | collagen, type V, alpha 2 | 0.076092 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0746584 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.070067 |
| RPS16 | ribosomal protein S16 | 0.064795 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0627028 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0576425 |
| RPS12 | ribosomal protein S12 | 0.0565229 |
| NBEAL1 | neurobeachin-like 1 | 0.0554915 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0536062 |
| RPL3 | ribosomal protein L3 | 0.0526003 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0519824 |
| ENO1 | enolase 1, (alpha) | 0.0516264 |
| RPL36A | ribosomal protein L36a | 0.0509917 |
| CALR | calreticulin | 0.0492753 |
| CALU | calumenin | 0.0491394 |
| B2M | beta-2-microglobulin | 0.0486098 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0469102 |
| RPS19 | ribosomal protein S19 | 0.0464734 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0444418 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0440112 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0412849 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0408475 |
| SUN1 | Sad1 and UNC84 domain containing 1 | 0.0401129 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0384518 |
| AFDN | afadin, adherens junction formation factor | 0.038108 |
| RPLP1 | ribosomal protein, large, P1 | 0.0378948 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0378859 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0378256 |
| ANK2 | ankyrin 2, neuronal | 0.037031 |
| RPS15 | ribosomal protein S15 | 0.0366134 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0364778 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0361294 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.035695 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0354372 |
| RPL23 | ribosomal protein L23 | 0.0353863 |
| CUL4B | cullin 4B | 0.0351656 |
| TBCD | tubulin folding cofactor D | 0.0350562 |
| DRC8 | dynein regulatory complex subunit 8 | 0.0349524 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0346874 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0344141 |
| TRIM37 | tripartite motif containing 37 | 0.0339984 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0339119 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0338955 |
| ATF4 | activating transcription factor 4 | 0.0337816 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0332253 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0332238 |
| ITSN2 | intersectin 2 | 0.0330419 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.032943 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0329095 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0328345 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0325308 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0323758 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.032094 |
| UBN2 | ubinuclein 2 | 0.031818 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0318093 |
| RPL26 | ribosomal protein L26 | 0.0317912 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0314715 |
| RPL37 | ribosomal protein L37 | 0.0312162 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0310644 |
| PHF21A | PHD finger protein 21A | 0.0307866 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0305707 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0304642 |
| LMAN1 | lectin, mannose-binding, 1 | 0.03044 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0299866 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0298512 |
| GOLGA2 | golgin A2 | 0.0297335 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.0296756 |
| LONP2 | lon peptidase 2, peroxisomal | 0.0296598 |
| SQSTM1 | sequestosome 1 | 0.0294191 |
| LPIN2 | lipin 2 | 0.0292907 |
| RPL27 | ribosomal protein L27 | 0.0292731 |
| CLIC4 | chloride intracellular channel 4 | 0.0292542 |
| HES4 | hes family bHLH transcription factor 4 | 0.0290823 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0287025 |
| PHF20 | PHD finger protein 20 | 0.0285727 |
| PCM1 | pericentriolar material 1 | 0.0285229 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0283454 |
| TJP1 | tight junction protein 1 | 0.0282478 |
| GLG1 | golgi glycoprotein 1 | 0.0282081 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0279203 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0276512 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | 0.0275522 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.0275376 |
| POU3F2 | POU class 3 homeobox 2 | 0.0272807 |
| NUFIP1 | nuclear fragile X mental retardation protein interacting protein 1 | 0.0270531 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0268378 |
| RPS5 | ribosomal protein S5 | 0.0267213 |
| PLBD1 | phospholipase B domain containing 1 | 0.0267116 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0264098 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0263934 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.026393 |
| USP21 | ubiquitin specific peptidase 21 | 0.0261572 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.026115 |
| NDRG1 | N-myc downstream regulated 1 | 0.0261115 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0260926 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0260111 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0756727 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0702253 |
| PEG10 | paternally expressed 10 | -0.0699164 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0641226 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0610171 |
| POTEF | POTE ankyrin domain family, member F | -0.0608283 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0585624 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0573497 |
| CENPF | centromere protein F, 350/400kDa | -0.0518184 |
| PCDH9 | protocadherin 9 | -0.0506686 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0497871 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0485318 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0476104 |
| EMP1 | epithelial membrane protein 1 | -0.0461757 |
| THBS1 | thrombospondin 1 | -0.0436254 |
| ACTG1 | actin gamma 1 | -0.0431373 |
| NRG1 | neuregulin 1 | -0.0427107 |
| PTMA | prothymosin, alpha | -0.0425092 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0424716 |
| MKI67 | marker of proliferation Ki-67 | -0.042036 |
| TPX2 | TPX2, microtubule-associated | -0.0419479 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0410922 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0410271 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0405944 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0394035 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.038753 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0363144 |
| CADM2 | cell adhesion molecule 2 | -0.0361498 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0346401 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0344592 |
| URI1 | URI1, prefoldin-like chaperone | -0.0339346 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0338751 |
| MYO10 | myosin X | -0.0337783 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0334983 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0333545 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0329631 |
| ANXA2 | annexin A2 | -0.0322617 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0320505 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0319849 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0315721 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0314967 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0314582 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0312239 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0304611 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0301263 |
| DEK | DEK proto-oncogene | -0.029869 |
| SLMAP | sarcolemma associated protein | -0.0293335 |
| OGA | O-GlcNAcase | -0.0291663 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0290186 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0289471 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0288308 |
| HMGA2 | high mobility group AT-hook 2 | -0.0287415 |
| MAP4 | microtubule-associated protein 4 | -0.0286672 |
| ZNF217 | zinc finger protein 217 | -0.0286562 |
| RTN4 | reticulon 4 | -0.0284944 |
| MTDH | metadherin | -0.0284848 |
| NUP153 | nucleoporin 153kDa | -0.0284841 |
| NEK7 | NIMA-related kinase 7 | -0.0282182 |
| METAP2 | methionyl aminopeptidase 2 | -0.0277041 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0276009 |
| HDAC2 | histone deacetylase 2 | -0.027553 |
| PFN1 | profilin 1 | -0.0275486 |
| DST | dystonin | -0.0272286 |
| MED12L | mediator complex subunit 12-like | -0.026949 |
| NKTR | natural killer cell triggering receptor | -0.0268956 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0268203 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0266141 |
| PLPP1 | phospholipid phosphatase 1 | -0.0265304 |
| H1-0 | H1.0 linker histone | -0.0259837 |
| VIM | vimentin | -0.0258647 |
| SETD5 | SET domain containing 5 | -0.0255355 |
| GPC3 | glypican 3 | -0.025535 |
| TMEM123 | transmembrane protein 123 | -0.0253754 |
| IPO7 | importin 7 | -0.0250062 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0249166 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0248993 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0248983 |
| ENAH | enabled homolog (Drosophila) | -0.0247547 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0246865 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0246509 |
| RAD51B | RAD51 paralog B | -0.0245201 |
| PDGFC | platelet derived growth factor C | -0.0244304 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0242871 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0242764 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0242753 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0240583 |
| CDC73 | cell division cycle 73 | -0.023969 |
| TCEA1 | transcription elongation factor A (SII), 1 | -0.0238998 |
| CCNL1 | cyclin L1 | -0.0238254 |
| ECT2 | epithelial cell transforming 2 | -0.0237405 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0235094 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0234713 |
| TUT4 | terminal uridylyl transferase 4 | -0.0234325 |
| DENND5B | DENN/MADD domain containing 5B | -0.02337 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0233312 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0233283 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0233164 |
| SHROOM3 | shroom family member 3 | -0.0233132 |
| CRY1 | cryptochrome circadian clock 1 | -0.0232931 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.023201 |
